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View article: Quantification of the cerebral pressure–flow relationship directional sensitivity: Reliability of shorter repeated squat–stand durations
Quantification of the cerebral pressure–flow relationship directional sensitivity: Reliability of shorter repeated squat–stand durations Open
The magnitude of changes in middle cerebral artery mean blood velocity (MCAv) is attenuated when mean arterial pressure (MAP) increases compared with when MAP decreases. This directional sensitivity has been characterized using a time‐corr…
View article: Directional sensitivity analysis of the cerebral pressure-flow relationship during normothermia and moderate hyperthermia
Directional sensitivity analysis of the cerebral pressure-flow relationship during normothermia and moderate hyperthermia Open
Recent evidence highlights the importance of considering directional sensitivity in dynamic cerebral autoregulation. The current analysis found no directional sensitivity in the cerebral pressure-flow relationship during 0.03- and 0.10-Hz …
View article: New evidence for baroreflex and respiratory chemoreflex-mediated cerebral sympathetic activation in humans
New evidence for baroreflex and respiratory chemoreflex-mediated cerebral sympathetic activation in humans Open
The results of the current study suggest that baroreflex and respiratory chemoreflex stressors elevate cerebral sympathetic nervous activity, quantified using the brain norepinephrine spillover method. However, the observed cerebral sympat…
View article: On the challenge of assessing dynamic cerebral autoregulation
On the challenge of assessing dynamic cerebral autoregulation Open
Connections link a sequence of three related research papers. The central article which links the other two papers has been published in Experimental Physiology. In a Connections article, an author (or authors) of the central article outli…
View article: Time-domain methods for quantifying dynamic cerebral blood flow autoregulation: Review and recommendations. A white paper from the Cerebrovascular Research Network (CARNet)
Time-domain methods for quantifying dynamic cerebral blood flow autoregulation: Review and recommendations. A white paper from the Cerebrovascular Research Network (CARNet) Open
Cerebral Autoregulation (CA) is an important physiological mechanism stabilizing cerebral blood flow (CBF) in response to changes in cerebral perfusion pressure (CPP). By maintaining an adequate, relatively constant supply of blood flow, C…
View article: A systematic review, meta-analysis <i>and</i> meta-regression amalgamating the driven approaches used <i>to</i> quantify dynamic cerebral autoregulation
A systematic review, meta-analysis <i>and</i> meta-regression amalgamating the driven approaches used <i>to</i> quantify dynamic cerebral autoregulation Open
Numerous driven techniques have been utilized to assess dynamic cerebral autoregulation (dCA) in healthy and clinical populations. The current review aimed to amalgamate this literature and provide recommendations to create greater standar…
View article: Acute isometric and dynamic exercise do not alter cerebral sympathetic nerve activity in healthy humans
Acute isometric and dynamic exercise do not alter cerebral sympathetic nerve activity in healthy humans Open
The impact of physiological stressors on cerebral sympathetic nervous activity (SNA) remains controversial. We hypothesized that cerebral noradrenaline (NA) spillover, an index of cerebral SNA, would not change during both submaximal isome…
View article: Directional sensitivity of the cerebral pressure-flow relationship during forced oscillations induced by oscillatory lower body negative pressure
Directional sensitivity of the cerebral pressure-flow relationship during forced oscillations induced by oscillatory lower body negative pressure Open
A directional sensitivity of the cerebral pressure-flow relationship has been described using repeated squat-stands. Oscillatory lower body negative pressure (OLBNP) is a reproducible method to characterize dynamic cerebral autoregulation …
View article: Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis
Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis Open
End‐stage kidney disease (ESKD) is associated with increased arterial stiffness and cognitive impairment. Cognitive decline is accelerated in ESKD patients on hemodialysis and may result from repeatedly inappropriate cerebral blood flow (C…
View article: Influence of high‐intensity interval training to exhaustion on the directional sensitivity of the cerebral pressure‐flow relationship in young endurance‐trained men
Influence of high‐intensity interval training to exhaustion on the directional sensitivity of the cerebral pressure‐flow relationship in young endurance‐trained men Open
We previously reported subtle dynamic cerebral autoregulation (dCA) alterations following 6 weeks of high-intensity interval training (HIIT) to exhaustion using transfer function analysis (TFA) on forced mean arterial pressure (MAP) oscill…
View article: Point/counterpoint: We should take the direction of blood pressure change into consideration for dynamic cerebral autoregulation quantification
Point/counterpoint: We should take the direction of blood pressure change into consideration for dynamic cerebral autoregulation quantification Open
Accumulating evidence suggests asymmetrical responses of cerebral blood flow during large transient changes in mean arterial pressure. Specifically, the augmentation in cerebral blood flow is attenuated when mean arterial pressure acutely …
View article: Sex-specific effects of cardiorespiratory fitness on age-related differences in cerebral hemodynamics
Sex-specific effects of cardiorespiratory fitness on age-related differences in cerebral hemodynamics Open
We present data pooled from three institutions to study the impact of age, sex, and cardiorespiratory fitness on cerebral hemodynamics. Cardiorespiratory fitness was positively associated with middle cerebral artery blood velocity in women…
View article: Directional sensitivity of the cerebral pressure-flow relationship in middle and posterior cerebral arteries using the repeated squat-stand model: within-day reproducibility and impact of diurnal variation in young healthy men and women
Directional sensitivity of the cerebral pressure-flow relationship in middle and posterior cerebral arteries using the repeated squat-stand model: within-day reproducibility and impact of diurnal variation in young healthy men and women Open
We recently employed repeated squat-stands (RSS) to quantify directional sensitivity of the cerebral-pressure flow relationship (i.e. hysteresis) using a novel metric. Within-day reproducibility and diurnal variation impacts of this metric…
View article: Losing the dogmatic view of cerebral autoregulation
Losing the dogmatic view of cerebral autoregulation Open
In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept suggested a relatively broad mean arterial pressure range (~60-150 m…
View article: POS-603 HEMODIALYSIS INDUCES TRANSIENT REDUCTIONS IN CEREBRAL BLOOD FLOW PULSATILITY AND REGIONAL ARTERIAL STIFFNESS
POS-603 HEMODIALYSIS INDUCES TRANSIENT REDUCTIONS IN CEREBRAL BLOOD FLOW PULSATILITY AND REGIONAL ARTERIAL STIFFNESS Open
View article: Effects of age and sex on middle cerebral artery blood velocity and flow pulsatility index across the adult lifespan
Effects of age and sex on middle cerebral artery blood velocity and flow pulsatility index across the adult lifespan Open
We present the largest dataset ( n = 524) pooled from three institutions to study how age and sex affect middle cerebral artery blood velocity (MCAv) and flow pulsatility index (PI) across the adult lifespan. We report the rate of MCAv dec…
View article: Utilization of the repeated squat-stand model for studying the directional sensitivity of the cerebral pressure-flow relationship
Utilization of the repeated squat-stand model for studying the directional sensitivity of the cerebral pressure-flow relationship Open
Hysteresis in the cerebral pressure-flow relationship describes the superior ability of the cerebrovasculature to buffer cerebral blood flow changes when mean arterial pressure (MAP) acutely increases compared to when MAP acutely decreases…
View article: P.19 Intradialytic Changes in Cerebral Blood Flow and Regional Changes in Arterial Stiffness
P.19 Intradialytic Changes in Cerebral Blood Flow and Regional Changes in Arterial Stiffness Open
View article: Multi-metrics assessment of dynamic cerebral autoregulation in middle and posterior cerebral arteries in young fit women
Multi-metrics assessment of dynamic cerebral autoregulation in middle and posterior cerebral arteries in young fit women Open
Individuals with low orthostatic tolerance show greater decrease in posterior cerebral artery mean blood velocity (PCAv mean ). Since young fit women often experience presyncopal symptoms, their posterior cerebral circulation may be prone …
View article: Comparable blood velocity changes in middle and posterior cerebral arteries during and following acute high‐intensity exercise in young fit women
Comparable blood velocity changes in middle and posterior cerebral arteries during and following acute high‐intensity exercise in young fit women Open
The cerebral blood flow response to high-intensity interval training (HIIT) remains unclear. HIIT induces surges in mean arterial pressure (MAP), which could be transmitted to the brain, especially early after exercise onset. The aim of th…
View article: Implications of habitual endurance and resistance exercise for dynamic cerebral autoregulation
Implications of habitual endurance and resistance exercise for dynamic cerebral autoregulation Open
New Findings What is the central question of this study? Does habitual resistance and endurance exercise modify dynamic cerebral autoregulation? What is the main finding and its importance? To the authors’ knowledge, this is the first stud…
View article: Six weeks of high‐intensity interval training to exhaustion attenuates dynamic cerebral autoregulation without influencing resting cerebral blood velocity in young fit men
Six weeks of high‐intensity interval training to exhaustion attenuates dynamic cerebral autoregulation without influencing resting cerebral blood velocity in young fit men Open
Elevated cardiorespiratory fitness (CRF) is associated with reduced dynamic cerebral autoregulation (dCA), but the impact of exercise training per se on dCA remains equivocal. In addition, resting cerebral blood flow (CBF) and dCA after hi…
View article: Cardiac remodeling after six weeks of high-intensity interval training to exhaustion in endurance-trained men
Cardiac remodeling after six weeks of high-intensity interval training to exhaustion in endurance-trained men Open
High-intensity interval training (HIIT) improves physical performance of endurance athletes, although studies examining its cardiovascular effects are sparse. We evaluated the impact of HIIT on blood pressure, heart rate, and cardiac cavit…
View article: Letter to the Editor: On the need of considering cardiorespiratory fitness when examining the influence of sex on dynamic cerebral autoregulation
Letter to the Editor: On the need of considering cardiorespiratory fitness when examining the influence of sex on dynamic cerebral autoregulation Open
View article: Dynamic cerebral autoregulation of endurance-trained men following 6 weeks of high-intensity interval training to exhaustion
Dynamic cerebral autoregulation of endurance-trained men following 6 weeks of high-intensity interval training to exhaustion Open
Elevated cardiorespiratory fitness (CRF) is associated with reduced dynamic cerebral autoregulation (dCA), but the impact of exercise training per se on dCA remains equivocal. In addition, resting cerebral blood flow (CBF) and dCA after hi…
View article: Cardiac remodeling after six weeks of high-intensity interval training to exhaustion in endurance-trained males
Cardiac remodeling after six weeks of high-intensity interval training to exhaustion in endurance-trained males Open
High-intensity interval training (HIIT) improves physical performance of endurance athletes, although studies examining its cardiovascular effects are sparse. We evaluated the impact of HIIT on blood pressure, heart rate and cardiac caviti…
View article: Dynamic cerebral autoregulation is attenuated in young fit women
Dynamic cerebral autoregulation is attenuated in young fit women Open
Young women exhibit higher prevalence of orthostatic hypotension with presyncopal symptoms compared to men. These symptoms could be influenced by an attenuated ability of the cerebrovasculature to respond to rapid blood pressure (BP) chang…
View article: Functional implications of impaired dynamic cerebral autoregulation in young healthy women; a comparative investigation
Functional implications of impaired dynamic cerebral autoregulation in young healthy women; a comparative investigation Open
Women exhibit higher prevalence of orthostatic hypotension with presyncopal symptoms compared to men. These symptoms could be influenced by an attenuated ability of the cerebrovasculature to respond to rapid changes in blood pressure (BP) …
View article: Influence du sexe sur l'autorégulation cérébrale dynamique chez des individus actifs et en santé
Influence du sexe sur l'autorégulation cérébrale dynamique chez des individus actifs et en santé Open
De plus en plus de données probantes dans la littérature démontrent des différences sexuelles dans la régulation du débit sanguin cérébral (DSC), notamment dans le DSC de repos et la réactivité vasculaire cérébrale au dioxyde de carbone. D…
View article: Diminished dynamic cerebral autoregulatory capacity with forced oscillations in mean arterial pressure with elevated cardiorespiratory fitness
Diminished dynamic cerebral autoregulatory capacity with forced oscillations in mean arterial pressure with elevated cardiorespiratory fitness Open
The effect that cardiorespiratory fitness has on the dynamic cerebral autoregulatory capacity during changes in mean arterial pressure ( MAP ) remains equivocal. Using a multiple‐metrics approach, challenging MAP across the spectrum of phy…