Lawrence Chan
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View article: Plasma bictegravir/emtricitabine/tenofovir alafenamide concentrations in transgender women with HIV on oestrogen‐based gender‐affirming hormone therapy in comparison to cisgender women living with HIV
Plasma bictegravir/emtricitabine/tenofovir alafenamide concentrations in transgender women with HIV on oestrogen‐based gender‐affirming hormone therapy in comparison to cisgender women living with HIV Open
View article: Exploring Sarcopenic Obesity in the Cancer Setting: Insights from the National Health and Nutrition Examination Survey on Prognosis and Predictors Using Machine Learning
Exploring Sarcopenic Obesity in the Cancer Setting: Insights from the National Health and Nutrition Examination Survey on Prognosis and Predictors Using Machine Learning Open
Objective: Sarcopenic obesity (SO) is a combination of depleted skeletal muscle mass and obesity, with a high prevalence, undetected onset, challenging diagnosis, and poor prognosis. However, studies on SO in cancer settings are limited. W…
View article: Functional Role of NOXA in Hypoxia-Mediated PD-L1 Inhibitor Response in Hepatocellular Carcinoma
Functional Role of NOXA in Hypoxia-Mediated PD-L1 Inhibitor Response in Hepatocellular Carcinoma Open
Hypoxia is a crucial characteristic of hepatocellular carcinoma (HCC) and contributes to immune resistance by upregulating PD-L1 and recruiting immunosuppressive cells. However, the molecular mechanisms of hypoxia-induced immunotherapy res…
View article: Inflammatory signaling pathways in pancreatic β-cell: New insights into type 2 diabetes pathogenesis
Inflammatory signaling pathways in pancreatic β-cell: New insights into type 2 diabetes pathogenesis Open
Type 2 diabetes (T2D) is a complex metabolic disorder with a growing global prevalence, and there is a linking between inflammation in pancreatic β-cell and impaired glucose homeostasis which has emerged as a key player in the pathogenesis…
View article: 1494 Sensor Lead Breach in Hypoglossal Nerve Stimulation Therapy
1494 Sensor Lead Breach in Hypoglossal Nerve Stimulation Therapy Open
Introduction Targeted hypoglossal nerve stimulation (HNS) offers an alternative treatment approach by activating lingual muscles for patients with moderate to severe OSA who are intolerant of CPAP therapy. Report of case We present a case …
View article: Identification and Patient Benefit Evaluation of Machine Learning Models for Predicting 90-Day Mortality After Endovascular Thrombectomy Based on Routinely Ready Clinical Information
Identification and Patient Benefit Evaluation of Machine Learning Models for Predicting 90-Day Mortality After Endovascular Thrombectomy Based on Routinely Ready Clinical Information Open
Endovascular thrombectomy (EVT) is regarded as the standard of care for acute ischemic stroke (AIS) patients with large vessel occlusion (LVO). However, the mortality rates for these patients remain alarmingly high. Dependable mortality pr…
View article: Functional Role of NOXA in Hypoxia-Mediated PD-L1 Inhibitor Response in Hepatocellular Carcinoma
Functional Role of NOXA in Hypoxia-Mediated PD-L1 Inhibitor Response in Hepatocellular Carcinoma Open
Hypoxia is a crucial characteristic of hepatocellular carcinoma (HCC) and contributes to immune resistance by upregulating PD-L1 and recruiting immunosuppressive cells. However, the molecular mechanisms of hypoxia-induced immunotherapy res…
View article: Kolmogorov–Arnold Network Model Integrated with Hypoxia Risk for Predicting PD-L1 Inhibitor Responses in Hepatocellular Carcinoma
Kolmogorov–Arnold Network Model Integrated with Hypoxia Risk for Predicting PD-L1 Inhibitor Responses in Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths, with immunotherapy being a first-line treatment at the advanced stage and beyond. Hypoxia plays a critical role in tumor progression and resistance to therapy. Thi…
View article: Evaluation of the effectiveness and cost-effectiveness of the chronic disease co-care (CDCC) Pilot Scheme: a study protocol
Evaluation of the effectiveness and cost-effectiveness of the chronic disease co-care (CDCC) Pilot Scheme: a study protocol Open
Background The Chronic Disease Co-Care (CDCC) Pilot Scheme is a government-subsidized program that aims to provide targeted copayment for the screening and management of hypertension, diabetes mellitus and pre-diabetes in the private healt…
View article: Kolmogorov-Arnold Network Model Integrated with Hypoxia Risk for Predicting PD-L1 Inhibitor Response in Hepatocellular Carcinoma
Kolmogorov-Arnold Network Model Integrated with Hypoxia Risk for Predicting PD-L1 Inhibitor Response in Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths, with immunotherapy being a first-line treatment at the advanced stage and onwards. Hypoxia plays a critical role in tumor progression and resistance to therapy. Th…
View article: Cross-sectional study of the association between triglyceride glucose-body mass index and obstructive sleep apnea risk
Cross-sectional study of the association between triglyceride glucose-body mass index and obstructive sleep apnea risk Open
BACKGROUND The triglyceride glucose-body mass index (TyG-BMI) is a novel indicator of insulin resistance (IR). Obstructive sleep apnea (OSA) is a prevalent disorder characterized by recurrent complete or partial collapse of the pharyngeal …
View article: Integrated clinical-radiomic model for predicting treatment response of concurrent chemo-radiotherapy and radiotherapy alone in controversial subgroup of AJCC/UICC ninth edition stage I nasopharyngeal cancer
Integrated clinical-radiomic model for predicting treatment response of concurrent chemo-radiotherapy and radiotherapy alone in controversial subgroup of AJCC/UICC ninth edition stage I nasopharyngeal cancer Open
Integrating with clinical and radiomic features could provide prognostic information on 5-year PFS under either treatment regimen, guiding individualized decisions of chemotherapy based on the predicted treatment outcome.
View article: Altered dynamic functional connectivity in antagonistic state in first-episode, drug-naïve patients with major depressive disorder
Altered dynamic functional connectivity in antagonistic state in first-episode, drug-naïve patients with major depressive disorder Open
Our study highlights the altered dynamics of the antagonistic state as a fundamental aspect of disrupted FNC in early MDD.
View article: An electronic health record-linked machine learning tool for diabetes risk assessment in adults with prediabetes
An electronic health record-linked machine learning tool for diabetes risk assessment in adults with prediabetes Open
View article: Clinical Applications of Fractional Flow Reserve Derived from Computed Tomography in Coronary Artery Disease
Clinical Applications of Fractional Flow Reserve Derived from Computed Tomography in Coronary Artery Disease Open
View article: Modular addition without black-boxes: Compressing explanations of MLPs that compute numerical integration
Modular addition without black-boxes: Compressing explanations of MLPs that compute numerical integration Open
The goal of mechanistic interpretability is discovering simpler, low-rank algorithms implemented by models. While we can compress activations into features, compressing nonlinear feature-maps -- like MLP layers -- is an open problem. In th…
View article: Contrast‐Enhanced Ultrasound‐Based Radiomics for the Prediction of Axillary Lymph Nodes Status in Breast Cancer
Contrast‐Enhanced Ultrasound‐Based Radiomics for the Prediction of Axillary Lymph Nodes Status in Breast Cancer Open
Background Breast cancer is the leading cause of cancer‐related deaths in the female population. Axillary lymph nodes (ALN) are a group of the most common metastatic sites of breast cancer. Timely assessment of ALN status is of paramount c…
View article: Comparative Analysis of Repeatability in CT Radiomics and Dosiomics Features under Image Perturbation: A Study in Cervical Cancer Patients
Comparative Analysis of Repeatability in CT Radiomics and Dosiomics Features under Image Perturbation: A Study in Cervical Cancer Patients Open
This study aims to evaluate the repeatability of radiomics and dosiomics features via image perturbation of patients with cervical cancer. A total of 304 cervical cancer patients with planning CT images and dose maps were retrospectively i…
View article: Compact Proofs of Model Performance via Mechanistic Interpretability
Compact Proofs of Model Performance via Mechanistic Interpretability Open
We propose using mechanistic interpretability -- techniques for reverse engineering model weights into human-interpretable algorithms -- to derive and compactly prove formal guarantees on model performance. We prototype this approach by fo…
View article: Comparison of Diagnosis Codes to Clinical Notes in Classifying Patients with Diabetic Retinopathy
Comparison of Diagnosis Codes to Clinical Notes in Classifying Patients with Diabetic Retinopathy Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Evaluating the Diagnostic Performance of Large Language Models on Complex Multimodal Medical Cases
Evaluating the Diagnostic Performance of Large Language Models on Complex Multimodal Medical Cases Open
Large language models showed interpretative reasoning in solving diagnostically challenging medical cases.
View article: Prognostic PET [11C]-acetate uptake is associated with hypoxia gene expression in patients with late-stage hepatocellular carcinoma – a bench to bed study
Prognostic PET [11C]-acetate uptake is associated with hypoxia gene expression in patients with late-stage hepatocellular carcinoma – a bench to bed study Open
Background Positron Emission Tomography (PET) with combined [ 18 F]-FDG and [ 11 C]-acetate (dual-tracer) is used for the management of hepatocellular carcinoma (HCC) patients, although its prognostic value and underlying molecular mechani…
View article: Enhancing Diagnostic Images to Improve the Performance of the Segment Anything Model in Medical Image Segmentation
Enhancing Diagnostic Images to Improve the Performance of the Segment Anything Model in Medical Image Segmentation Open
Medical imaging serves as a crucial tool in current cancer diagnosis. However, the quality of medical images is often compromised to minimize the potential risks associated with patient image acquisition. Computer-aided diagnosis systems h…
View article: Diversidad y captura de CO2 del arbolado del Parque Ecológico Zazil, Chetumal, Quintana Roo
Diversidad y captura de CO2 del arbolado del Parque Ecológico Zazil, Chetumal, Quintana Roo Open
Diferentes factores, como la rápida urbanización y el uso desmedido de combustibles fósiles para las actividades económicas que se llevan a cabo dentro de las ciudades, han contribuido al aumento de los Gases de Efecto Invernadero (GEI), s…
View article: Evaluating Language-Model Agents on Realistic Autonomous Tasks
Evaluating Language-Model Agents on Realistic Autonomous Tasks Open
In this report, we explore the ability of language model agents to acquire resources, create copies of themselves, and adapt to novel challenges they encounter in the wild. We refer to this cluster of capabilities as "autonomous replicatio…
View article: CT-based methods for assessment of metabolic dysfunction associated with fatty liver disease
CT-based methods for assessment of metabolic dysfunction associated with fatty liver disease Open
View article: Evaluating the Diagnostic Performance of Large Language Models on Complex Multimodal Medical Cases (Preprint)
Evaluating the Diagnostic Performance of Large Language Models on Complex Multimodal Medical Cases (Preprint) Open
UNSTRUCTURED Large language models showed interpretative reasoning in solving diagnostically challenging medical cases.
View article: Pretreatment radiomic biomarker for immunotherapy responder prediction in stage IB–IV NSCLC (LCDigital-IO Study): a multicenter retrospective study
Pretreatment radiomic biomarker for immunotherapy responder prediction in stage IB–IV NSCLC (LCDigital-IO Study): a multicenter retrospective study Open
Background The predictive efficacy of current biomarker of immune checkpoint inhibitors (ICIs) is not sufficient. This study investigated the causality between radiomic biomarkers and immunotherapy response status in patients with stage IB…
View article: Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice
Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice Open
View article: Hypoxia-related genes and PD-L1 inhibitor resistance in hepatocellular carcinoma.
Hypoxia-related genes and PD-L1 inhibitor resistance in hepatocellular carcinoma. Open
158 Background: PD-L1 inhibitor in combination with anti-angiogenic drug has become the first-line treatment strategy for unresectable hepatocellular carcinoma (HCC). However, PD-L1 inhibitor resistance remains an essential issue in treati…