Explanipedia

Draft genome of Corynebacterium glycinophilum S209 isolated from healthy human skin Open

Sandra Jablonska, Lawrence M. Nelson, Grace Finger, Alex Kula, Catherine Putonti · 2025

Corynebacterium glycinophilum is an understudied species of this genus, although it has been identified in dairy products as well as the human skin microbiome. Recently, we isolated a strain from the skin of a healthy human female, and her…

Draft genome sequences of Staphylococcus species isolated from urine samples from asymptomatic females Open

Sandra Jablonska, Lawrence M. Nelson, Grace Finger, Alex Kula, Catherine Putonti · 2025

The female urinary tract is host to several different Staphylococcus species, both uropathogens and commensals. To further investigate these species, we sequenced the genomes of four isolates from voided urine samples collected from asympt…

Draft genome sequences of Staphylococcus hominis strains O226 and O218 and Micrococcus luteus O220 isolated from the buccal swabs of healthy individuals Open

Sandra Jablonska, Lawrence M. Nelson, Grace Finger, Alex Kula, Catherine Putonti · 2025

To investigate the genomic features of rare oral commensals in healthy individuals, we present the draft genome sequences of Staphylococcus hominis strains O226 and O218 and Micrococcus luteus strain O220. All three of these isolates were …

Draft genome sequence of Staphylococcus aureus N208 isolated from a nasal swab of a healthy female Open

Sandra Jablonska, Lawrence M. Nelson, Grace Finger, Alex Kula, Catherine Putonti · 2025

Staphylococcus aureus , a common member of the healthy human microbiota, is an opportunistic pathogen. To investigate the genomic features of this species in healthy individuals, we present the draft genome sequence of S. aureus N208, isol…

Women’s hormonal health research and care: the times, they are a-changin’ Open

Joan T. Merrill, Lawrence M. Nelson · 2025

Editorial: Insights in developmental endocrinology: 2023 Open

Lawrence M. Nelson, Mayank Choubey, Hiroyasu Kamei, Christine Rampon · 2024

Keywords: developmental endocrinology, wisdom of the body, homeostasis, integrative biology, maternal fetal interface, women's hormonal health, hormonal literacy, science advocacy

A social movement: mind the gap in women’s healthcare and research Open

Lawrence M. Nelson · 2024

Primary Ovarian Insufficiency: A Case of the Cart before the Horse Open

Karima Hijane, Lawrence M. Nelson · 2024

Overt Primary Ovarian Insufficiency (POI) is a rare disorder characterized by a constellation of other rare conditions, posing significant diagnostic and management challenges. This disorder necessitates a global mechanism for information …

Editorial: Pathophysiology and management of amenorrhea and estradiol deficiency in girls and young women Open

Lawrence M. Nelson, Joshua Johnson · 2024

Editorial: Pathophysiology and management of amenorrhea and estradiol deficiency in girls and young women

A call for a US National Institute of Women’s Health and Human Development Open

Lawrence M. Nelson · 2024

Keywords: women's health activism, women's health funding, women's health policy, women's health research, digital medical hub, community-based participatory research

Primary Ovarian Insufficiency: A new paradigm for care and research Open

Lawrence M. Nelson · 2024

bone, heart, and brain health.There is a natural decrease in 17-Beta-Estradiol levels towards menopause, but 17-Beta-Estradiol deficiency is also seen in POI.Unfortunately, women's health is widely under-researched, and this becomes obviou…

My 28 Days - a global digital women’s health initiative for evaluation and management of secondary amenorrhea: case report and literature review Open

Lawrence M. Nelson, Hillary Spencer, Karima Hijane, Payom Thinuan, Chaninan W. Nelson , et al. · 2023

There is a need to close the gap between knowledge and action in health care. Effective care requires a convenient and reliable distribution process. As global internet and mobile communication increase capacity, innovative approaches to d…

The truth about 17-beta estradiol: menopause beyond “old wives’ tales” Open

Lawrence M. Nelson · 2023

OPINION article Front. Endocrinol., 11 September 2023Sec. Developmental Endocrinology Volume 14 - 2023 | https://doi.org/10.3389/fendo.2023.1229804

Editorial: A year in review: discussions in developmental endocrinology Open

Lawrence M. Nelson · 2023

EDITORIAL article Front. Endocrinol., 25 May 2023Sec. Developmental Endocrinology Volume 14 - 2023 | https://doi.org/10.3389/fendo.2023.1213095

Editorial: Insights in developmental endocrinology: 2021 Open

Lawrence M. Nelson · 2023

EDITORIAL article Front. Endocrinol., 02 February 2023Sec. Developmental Endocrinology Volume 14 - 2023 | https://doi.org/10.3389/fendo.2023.1129090

Causal and Candidate Gene Variants in a Large Cohort of Women With Primary Ovarian Insufficiency Open

Bushra Gorsi, Edgar J. Hernández, Marvin Barry Moore, Mika Moriwaki, Clement Y. Chow , et al. · 2021

Context A genetic etiology likely accounts for the majority of unexplained primary ovarian insufficiency (POI). Objective We hypothesized that heterozygous rare variants and variants in enhanced categories are associated with POI. Design T…

Optimizing Fertility in Primary Ovarian Insufficiency: Case Report and Literature Review Open

Kensuly C. Piedade, Hillary Spencer, Luca Persani, Lawrence M. Nelson · 2021

Primary ovarian insufficiency (POI) is a clinical spectrum of ovarian dysfunction. Overt POI presents with oligo/amenorrhea and hypergonadotropic hypogonadism before age 40 years. Overt POI involves chronic health problems to include incre…

OR31-06 Candidate Gene Variants in a Large Cohort of Women with Primary Ovarian Insufficiency Open

Bushra Gorsi, Mika Moriwaki, Marvin Barry Moore, Aleksandar Rajkovic, Lawrence M. Nelson , et al. · 2020

Primary ovarian insufficiency (POI) is highly heritable. The majority of cases have no known cause. We hypothesized that mutations in previously identified genes or genes from the same pathways are the cause of POI in a recessive or domina…

PMU87 REVIEW OF ORPHAN TREATMENTS ASSESSED BY NICE AND THE SMC IN THE UK. Open

Lawrence M. Nelson, C. Marsh, Shawn L. Ralston, S. Chadda · 2019

Fragile X Associated Primary Ovarian Insufficiency (FXPOI): Case Report and Literature Review Open

Dorothy A. Fink, Lawrence M. Nelson, Reed E. Pyeritz, Joshua Johnson, Stephanie L. Sherman , et al. · 2018

Abnormalities in the X-linked FMR1 gene are associated with a constellation of disorders, which have broad and profound implications for the person first diagnosed, and extended family members of all ages. The rare and pleiotropic n…

A randomized controlled study of a consent intervention for participating in an NIH genome sequencing study Open

Erin Turbitt, Paola Chrysostomou, Holly L. Peay, Alexis R. Heidlebaugh, Lawrence M. Nelson , et al. · 2018

The long Heavy Chain Determinant Region 3 (HCDR3) antibodies that neutralize virus bind the CD4 binding site (CD4 bs). Open

David Easterhoff, Anthony Moody M., Daniela Fera, Hao Cheng, Ackerman Margaret , et al. · 2017

Purified recombinant monoclonal antibodies (mAbs) were assayed by ELISA for (A) blocking the binding of soluble CD4 to AE.A244gp120, and (B) sensitivity to the CD4 binding site mutations Δ371I/P363N, D368R, N276A, and T278A in the AE.A244g…

Hormone replacement therapy in young women with primary ovarian insufficiency and early menopause Open

Shannon D. Sullivan, Philip M. Sarrel, Lawrence M. Nelson · 2016

Hormone replacement therapy in young women with surgical primary ovarian insufficiency Open

Philip M. Sarrel, Shannon D. Sullivan, Lawrence M. Nelson · 2016

Functional characteristics of C. albicans- and CMV-specific CD4 T cells in healthy subjects. Open

Liu Fengliang, Xiuzhen Fan, Auclair Sarah, Ferguson Monique, Sun Jiaren , et al. · 2016

(A) Representative flow cytometric plots are shown for different cytokine expression in CFSE-low CD4+ T cells in PBMC after cognate antigen C. albicans (top) or CMV (bottom) stimulation. CFSE-labeled healthy donor PBMCs were …

Characteristics of HIV-infected subjects from the RV21 cohort*. Open

Liu Fengliang, Xiuzhen Fan, Auclair Sarah, Ferguson Monique, Sun Jiaren , et al. · 2016

Characteristics of HIV-infected subjects from the RV21 cohort^*.

HIV infectivity in functional subsets of C. albicans-specific CD4 T cells. Open

Liu Fengliang, Xiuzhen Fan, Auclair Sarah, Ferguson Monique, Sun Jiaren , et al. · 2016

(A) Overall in vitro HIV susceptibility of C. albicans- and CMV-specific CD4 T cells in the same healthy donor PBMCs. CFSE-labeled PBMCs were stimulated with C. albicans (left) or CMV (right) for 3 days, and exp…

Primer sequences of HIV DNA quantification. Open

Liu Fengliang, Xiuzhen Fan, Auclair Sarah, Ferguson Monique, Sun Jiaren , et al. · 2016

Primer sequences for quantification of gene expression. Open

Liu Feng-liang, Xiuzhen Fan, Auclair Sarah, Ferguson Monique, Sun Jiaren , et al. · 2016

Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1 Open

Nils Landegren, Donald Sharon, Eva Freyhult, Åsa Hallgren, Daniel Eriksson , et al. · 2016

Autoimmune polyendocrine syndrome type 1 (APS1) is a monogenic disorder that features multiple autoimmune disease manifestations. It is caused by mutations in the Autoimmune regulator (AIRE) gene, which promote thymic display of thousands …

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