Lawrence P. Binding
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View article: The effect of cortical and subcortical parcel volumes on postictal generalized <scp>EEG</scp> suppression
The effect of cortical and subcortical parcel volumes on postictal generalized <span>EEG</span> suppression Open
Objective Alterations to brain structures and networks involved in central autonomic and respiratory control are possible biomarkers of SUDEP, but were mainly demonstrated in people at high risk. Postictal generalized EEG suppression (PGES…
View article: Data-driven modelling of tau pathology reveals distinct progressive supranuclear palsy subtypes
Data-driven modelling of tau pathology reveals distinct progressive supranuclear palsy subtypes Open
Progressive supranuclear palsy (PSP) is a heterogeneous neurodegenerative disease characterised by the accumulation of misfolded 4-repeat tau within neurones and glial cells. There is limited longitudinal data on pathologically confirmed P…
View article: Distinct gray matter and metabolic characteristics in hypothalamic hamartoma network with different semiology
Distinct gray matter and metabolic characteristics in hypothalamic hamartoma network with different semiology Open
Objective Hypothalamic hamartomas (HHs) are developmental malformations associated with focal epilepsy. We investigated the patterns of gray matter morphology and cerebral metabolism in individuals with HHs, with and without focal to bilat…
View article: Neuropathological stages of neuronal, astrocytic and oligodendrocytic alpha-synuclein pathology in Parkinson’s disease
Neuropathological stages of neuronal, astrocytic and oligodendrocytic alpha-synuclein pathology in Parkinson’s disease Open
Alpha-synucleinopathies are neurodegenerative diseases characterized by the spread of alpha-synuclein (α-syn) aggregates throughout the central nervous system in a stereotypical manner. These diseases include Lewy body disease (LBD), which…
View article: Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection
Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection Open
Approximately 40% of individuals undergoing anterior temporal lobe resection for temporal lobe epilepsy experience episodic memory decline. There has been a focus on early memory network changes; longer-term plasticity and its impact on me…
View article: Impact of anterior callosal disconnection on picture naming in frontal lobe epilepsy surgery
Impact of anterior callosal disconnection on picture naming in frontal lobe epilepsy surgery Open
Epilepsy surgery in focal, drug-resistant frontal lobe epilepsy can be curative and resection is aimed at seizure freedom. The cognitive impact of surgery, however, is less clear-cut. On one hand, resection of the epileptogenic zone can di…
View article: Long‐term neuroplasticity in language networks after anterior temporal lobe resection
Long‐term neuroplasticity in language networks after anterior temporal lobe resection Open
Objective Anterior temporal lobe resection (ATLR) is an effective treatment for drug‐resistant temporal lobe epilepsy (TLE), although language deficits may occur after both left and right ATLR. Functional reorganization of the language net…
View article: Microangiopathy in temporal lobe epilepsy with diffusion MRI alterations and cognitive decline
Microangiopathy in temporal lobe epilepsy with diffusion MRI alterations and cognitive decline Open
White matter microvascular alterations in temporal lobe epilepsy (TLE) may be relevant to acquired neurodegenerative processes and cognitive impairments associated with this condition. We quantified microvascular changes, myelin, axonal, g…
View article: Microangiopathy in temporal lobe epilepsy with diffusion MRI alterations and cognitive decline
Microangiopathy in temporal lobe epilepsy with diffusion MRI alterations and cognitive decline Open
White matter microvascular alterations in temporal lobe epilepsy (TLE) can influence local hemodynamics and are relevant to understanding acquired neurodegenerative processes and cognitive impairment associated with this condition. We quan…
View article: Predictors of long‐term memory and network connectivity 10 years after anterior temporal lobe resection
Predictors of long‐term memory and network connectivity 10 years after anterior temporal lobe resection Open
Objective Anterior temporal lobe resection (ATLR) effectively controls seizures in medically refractory temporal lobe epilepsy but risks significant episodic memory decline. Beyond 1 year postoperatively, the influence of preoperative clin…
View article: Naming fMRI-guided white matter language tract volumes influence naming decline after temporal lobe resection
Naming fMRI-guided white matter language tract volumes influence naming decline after temporal lobe resection Open
Objective The aim of this study was to explore the relation of language functional MRI (fMRI)-guided tractography with postsurgical naming decline in people with temporal lobe epilepsy (TLE). Methods Twenty patients with unilateral TLE (9 …
View article: Long-Term Memory Plasticity: A Decade-Long Connectivity Study Post Anterior Temporal Lobe Resection
Long-Term Memory Plasticity: A Decade-Long Connectivity Study Post Anterior Temporal Lobe Resection Open
Approximately 40% of individuals undergoing anterior temporal lobe resection for temporal lobe epilepsy experience episodic memory decline. Despite the importance of early memory network changes, long-term plasticity and its impact on memo…
View article: Thalamostriatal disconnection underpins long-term seizure freedom in frontal lobe epilepsy surgery
Thalamostriatal disconnection underpins long-term seizure freedom in frontal lobe epilepsy surgery Open
Around 50% of patients undergoing frontal lobe surgery for focal drug-resistant epilepsy become seizure free post-operatively; however, only about 30% of patients remain seizure free in the long-term. Early seizure recurrence is likely to …
View article: Contribution of White Matter Fiber Bundle Damage to Language Change After Surgery for Temporal Lobe Epilepsy
Contribution of White Matter Fiber Bundle Damage to Language Change After Surgery for Temporal Lobe Epilepsy Open
We demonstrate a relationship between fiber transection and naming decline after temporal lobe resection. Individualized surgical planning to spare white matter fiber bundles could help to preserve language function after surgery.
View article: The impact of temporal lobe epilepsy surgery on picture naming and its relationship to network metric change
The impact of temporal lobe epilepsy surgery on picture naming and its relationship to network metric change Open
View article: Verbal fluency functional magnetic resonance imaging detects anti‐seizure effects and affective side effects of perampanel in people with focal epilepsy
Verbal fluency functional magnetic resonance imaging detects anti‐seizure effects and affective side effects of perampanel in people with focal epilepsy Open
Perampanel, a noncompetitive antagonist of the postsynaptic a‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic (AMPA) receptor, is effective for controlling focal to bilateral tonic–clonic seizures but is also known to increase feelings of an…
View article: Episodic memory network connectivity in temporal lobe epilepsy
Episodic memory network connectivity in temporal lobe epilepsy Open
Objective Temporal lobe epilepsy (TLE) affects brain networks and is associated with impairment of episodic memory. Temporal and extratemporal reorganization of memory functions is described in functional magnetic resonance imaging (fMRI) …
View article: Structure and function of language networks in temporal lobe epilepsy
Structure and function of language networks in temporal lobe epilepsy Open
Individuals with temporal lobe epilepsy (TLE) may have significant language deficits. Language capabilities may further decline following temporal lobe resections. The language network, comprising dispersed gray matter regions interconnect…