Laxmikanth Kollipara
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View article: Spermidine supplementation and protein restriction protect from organismal and brain aging independently
Spermidine supplementation and protein restriction protect from organismal and brain aging independently Open
Brain aging and cognitive decline are significant biomedical and societal concerns. Both dietary restriction, such as limiting protein intake, and fasting, which restricts the timing of food consumption, have been proposed as strategies to…
View article: A reference database enabling in-depth proteome and PTM analysis of mouse immune cells
A reference database enabling in-depth proteome and PTM analysis of mouse immune cells Open
Spectral libraries fulfill multiple functions in biological and analytical applications. For biologists, these libraries provide a valuable resource to verify the presence and abundance of proteins or pathways within a selected cell type t…
View article: Editorial: Immunomics of the immune regulatory networks in the one health perspective
Editorial: Immunomics of the immune regulatory networks in the one health perspective Open
View article: <i>HNRNPA1 de novo</i> Variant Associated with Early Childhood Onset, Rapidly Progressive Generalized Myopathy
<i>HNRNPA1 de novo</i> Variant Associated with Early Childhood Onset, Rapidly Progressive Generalized Myopathy Open
HNRNPA1 variants are known to cause degenerative motoneuron and muscle diseases which manifests in middle age or later. We report on a girl with early childhood onset, rapidly progressive generalized myopathy including ultrastructural find…
View article: Methylmalonic acidemia triggers lysosomal-autophagy dysfunctions
Methylmalonic acidemia triggers lysosomal-autophagy dysfunctions Open
View article: Interruption of p53-MDM2 Interaction by Nutlin-3a in Human Lymphoma Cell Models Initiates a Cell-Dependent Global Effect on Transcriptome and Proteome Level
Interruption of p53-MDM2 Interaction by Nutlin-3a in Human Lymphoma Cell Models Initiates a Cell-Dependent Global Effect on Transcriptome and Proteome Level Open
In most lymphomas, p53 signaling pathway is inactivated by various mechanisms independent to p53 gene mutations or deletions. In many cases, p53 function is largely regulated by alterations in the protein abundance levels by the action of …
View article: Supplementary Data from Exposure of Patient-Derived Mesenchymal Stromal Cells to TGFB1 Supports Fibrosis Induction in a Pediatric Acute Megakaryoblastic Leukemia Model
Supplementary Data from Exposure of Patient-Derived Mesenchymal Stromal Cells to TGFB1 Supports Fibrosis Induction in a Pediatric Acute Megakaryoblastic Leukemia Model Open
Figure S1. Cells isolated from bone marrow aspirates of ML-DS and AMKL patients as well HDs fulfilled the minimal ISCT criteria of MSCs. Figure S2. Unsupervised hierarchical clustering of MSCs without grouping according to their entities. …
View article: Data from Exposure of Patient-Derived Mesenchymal Stromal Cells to TGFB1 Supports Fibrosis Induction in a Pediatric Acute Megakaryoblastic Leukemia Model
Data from Exposure of Patient-Derived Mesenchymal Stromal Cells to TGFB1 Supports Fibrosis Induction in a Pediatric Acute Megakaryoblastic Leukemia Model Open
Bone marrow fibrosis (BMF) is a rare complication in acute leukemia. In pediatrics, it predominantly occurs in acute megakaryoblastic leukemia (AMKL) and especially in patients with trisomy 21, called myeloid leukemia in Down syndrome (ML-…
View article: Data from Exposure of Patient-Derived Mesenchymal Stromal Cells to TGFB1 Supports Fibrosis Induction in a Pediatric Acute Megakaryoblastic Leukemia Model
Data from Exposure of Patient-Derived Mesenchymal Stromal Cells to TGFB1 Supports Fibrosis Induction in a Pediatric Acute Megakaryoblastic Leukemia Model Open
Bone marrow fibrosis (BMF) is a rare complication in acute leukemia. In pediatrics, it predominantly occurs in acute megakaryoblastic leukemia (AMKL) and especially in patients with trisomy 21, called myeloid leukemia in Down syndrome (ML-…
View article: Supplementary Data from Exposure of Patient-Derived Mesenchymal Stromal Cells to TGFB1 Supports Fibrosis Induction in a Pediatric Acute Megakaryoblastic Leukemia Model
Supplementary Data from Exposure of Patient-Derived Mesenchymal Stromal Cells to TGFB1 Supports Fibrosis Induction in a Pediatric Acute Megakaryoblastic Leukemia Model Open
Figure S1. Cells isolated from bone marrow aspirates of ML-DS and AMKL patients as well HDs fulfilled the minimal ISCT criteria of MSCs. Figure S2. Unsupervised hierarchical clustering of MSCs without grouping according to their entities. …
View article: Periostin as a blood biomarker of muscle cell fibrosis, cardiomyopathy and disease severity in myotonic dystrophy type 1
Periostin as a blood biomarker of muscle cell fibrosis, cardiomyopathy and disease severity in myotonic dystrophy type 1 Open
View article: The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro
The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro Open
Remdesivir is a prodrug of a nucleoside analog and the first antiviral therapeutic approved for coronavirus disease. Recent cardiac safety concerns and reports on remdesivir-related acute kidney injury call for a better characterization of…
View article: Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability
Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability Open
View article: eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction
eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction Open
Mitochondrial function declines during brain aging and is suspected to play a key role in age-induced cognitive decline and neurodegeneration. Supplementing levels of spermidine, a body-endogenous metabolite, has been shown to promote mito…
View article: INPP5K and SIL1 associated pathologies with overlapping clinical phenotypes converge through dysregulation of PHGDH
INPP5K and SIL1 associated pathologies with overlapping clinical phenotypes converge through dysregulation of PHGDH Open
Marinesco-Sjögren syndrome is a rare human disorder caused by biallelic mutations in SIL1 characterized by cataracts in infancy, myopathy and ataxia, symptoms which are also associated with a novel disorder caused by mutations in INPP5K. W…
View article: Regulatory Function of Sympathetic Innervation on the Endo/Lysosomal Trafficking of Acetylcholine Receptor
Regulatory Function of Sympathetic Innervation on the Endo/Lysosomal Trafficking of Acetylcholine Receptor Open
Recent studies have demonstrated that neuromuscular junctions are co-innervated by sympathetic neurons. This co-innervation has been shown to be crucial for neuromuscular junction morphology and functional maintenance. To improve our under…
View article: Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome
Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome Open
Gray platelet syndrome (GPS) is a rare recessive disorder caused by biallelic variants in NBEAL2 and characterized by bleeding symptoms, the absence of platelet α-granules, splenomegaly, and bone marrow (BM) fibrosis. Due to the rarity of …
View article: Mitochondrial CLPP2 Assists Coordination and Homeostasis of Respiratory Complexes
Mitochondrial CLPP2 Assists Coordination and Homeostasis of Respiratory Complexes Open
Protein homeostasis in eukaryotic organelles and their progenitor prokaryotes is regulated by a series of proteases including the caseinolytic protease (CLPP). CLPP has essential roles in chloroplast biogenesis and maintenance, but the sig…
View article: First clinical and myopathological description of a myofibrillar myopathy with congenital onset and homozygous mutation in <i>FLNC</i>
First clinical and myopathological description of a myofibrillar myopathy with congenital onset and homozygous mutation in <i>FLNC</i> Open
Filamin C (encoded by the FLNC gene) is a large actin‐cross‐linking protein involved in shaping the actin cytoskeleton in response to signaling events both at the sarcolemma and at myofibrillar Z‐discs of cross‐striated muscle cells. Multi…
View article: Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome
Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome Open
Gray platelet syndrome (GPS) is a rare recessive disorder caused by variants in NBEAL2 and characterized by bleeding symptoms, the absence of platelet ɑ-granules, splenomegaly and bone marrow (BM) fibrosis. Due to its rarity, it has been d…
View article: Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and GDF11 in Mouse Serum
Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and GDF11 in Mouse Serum Open
Growth differentiation factor 11 (GDF11) is a TGF‐β superfamily circulating factor that regulates cardiomyocyte size in rodents, sharing 90% amino acid sequence identity in the active domains with myostatin (GDF8)—the major determinant of …
View article: Coordination and assembly of protein complexes encoded across mitochondrial and nuclear genomes is assisted by CLPP2 in<i>Arabidopsis thaliana</i>
Coordination and assembly of protein complexes encoded across mitochondrial and nuclear genomes is assisted by CLPP2 in<i>Arabidopsis thaliana</i> Open
Protein homeostasis in eukaryotic organelles and their progenitor prokaryotes is regulated by a series of proteases including the caseinolytic protease (CLPP). CLPP has essential roles in chloroplast biogenesis and maintenance, but the sig…
View article: Proteogenomics of Colorectal Cancer Liver Metastases: Complementing Precision Oncology with Phenotypic Data
Proteogenomics of Colorectal Cancer Liver Metastases: Complementing Precision Oncology with Phenotypic Data Open
Hotspot testing for activating KRAS mutations is used in precision oncology to select colorectal cancer (CRC) patients who are eligible for anti-EGFR treatment. However, even for KRASwildtype tumors anti-EGFR response rates are <30%, while…
View article: CCDC 1876852: Experimental Crystal Structure Determination
CCDC 1876852: Experimental Crystal Structure Determination Open
View article: Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints
Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints Open
Mitochondria are dynamic organelles with diverse functions in tissues such as liver and skeletal muscle. To unravel the mitochondrial contribution to tissue-specific physiology, we performed a systematic comparison of the mitochondrial pro…
View article: Deciphering the role of autophagy and exosomes in human lymphoma
Deciphering the role of autophagy and exosomes in human lymphoma Open
The orchestrated homeostatic action of autophagy and exosome biogenesis provides a potential causal relation with lymphomagenesis. This study aims to characterize the differently expressed proteins associated with both above-mentioned path…
View article: Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S
Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S Open
We present inhibitors of drug resistant mutants of EGFR including T790M and C797S. In addition, we present the first X-ray crystal structures of covalent inhibitors in complex with C797S-mutated EGFR to gain insight into their binding mode.
View article: Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures
Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures Open
View article: Disentangling thermal stress responses in a reef-calcifier and its photosymbionts by shotgun proteomics
Disentangling thermal stress responses in a reef-calcifier and its photosymbionts by shotgun proteomics Open
The proliferation of key marine ecological engineers and carbonate producers often relies on their association with photosymbiotic algae. Evaluating stress responses of these organisms is important to predict their fate under future climat…
View article: Simple, scalable, and ultrasensitive tip-based identification of protease substrates
Simple, scalable, and ultrasensitive tip-based identification of protease substrates Open