Laylan Bramasole
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View article: DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity
DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity Open
The immunoproteasome is a specialized type of proteasome involved in MHC class I antigen presentation, antiviral adaptive immunity, autoimmunity, and is also part of a broader response to stress. Whether the immunoproteasome is regulated b…
View article: Profiling Proteasome Activities in Peripheral Blood – A Novel Biomarker Approach
Profiling Proteasome Activities in Peripheral Blood – A Novel Biomarker Approach Open
The proteasome system in the cell degrades the majority of intracellular proteins.The broad nature of its substrates makes proteasome activity crucial for many cellular functions, such as protein quality control, transcription, apoptosis, …
View article: The Proteasome Lid Triggers COP9 Signalosome Activity during the Transition of Saccharomyces cerevisiae Cells into Quiescence
The Proteasome Lid Triggers COP9 Signalosome Activity during the Transition of Saccharomyces cerevisiae Cells into Quiescence Open
The class of Cullin–RING E3 ligases (CRLs) selectively ubiquitinate a large portion of proteins targeted for proteolysis by the 26S proteasome. Before degradation, ubiquitin molecules are removed from their conjugated proteins by deubiquit…