Lê Hữu Song
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View article: Subtype-specific prognostic implications of plasma-detected PIK3CA mutations in Vietnamese breast cancer patients
Subtype-specific prognostic implications of plasma-detected PIK3CA mutations in Vietnamese breast cancer patients Open
Background PIK3CA mutations are among the most frequent genomic alterations in breast cancer (BC), contributing to disease progression and therapeutic resistance. Non-invasive blood assays can reveal tumor-specific DNA alterations, enhanci…
View article: Incidental frontal process of the maxilla uptake on bone scintigraphy: a benign phenomenon validated by multimodal imaging and metabolic stability
Incidental frontal process of the maxilla uptake on bone scintigraphy: a benign phenomenon validated by multimodal imaging and metabolic stability Open
Objectives To characterize incidental radiotracer uptake in the frontal process of the maxilla (FPM) on bone scintigraphy and evaluate its clinical significance through multimodal correlation. Methods This retrospective study (2019–2024) i…
View article: Supplementary Table 1 from Association between Sleep Duration and Colorectal Adenomas: Findings from a Case–Control Study in Vietnam
Supplementary Table 1 from Association between Sleep Duration and Colorectal Adenomas: Findings from a Case–Control Study in Vietnam Open
This supplementary table describes the distributions of baseline characteristics among study participants by cases versus controls
View article: Beyond H. pylori: Streptococcal Co-Infections and Their Hidden Impact on Gastric Lesions in Vietnam
Beyond H. pylori: Streptococcal Co-Infections and Their Hidden Impact on Gastric Lesions in Vietnam Open
Background/Objectives: Helicobacter pylori (H. pylori) is a well-established pathogen associated with chronic gastritis and gastric malignancies. Recent studies suggest that members of the Streptococcus anginosus group (SAG), particularly …
View article: Serological cross-reactivity and identification of an acute Seoul orthohantavirus case in a dengue outbreak from Vietnam
Serological cross-reactivity and identification of an acute Seoul orthohantavirus case in a dengue outbreak from Vietnam Open
Background In dengue-endemic regions like Vietnam, viral haemorrhagic fevers (VHFs) with overlapping clinical presentations often lead to misdiagnoses. This study investigated alternative VHF pathogens in patients clinically suspected of d…
View article: Circulating miRNAs combined with AFP improve diagnostic accuracy for HBV-associated hepatocellular carcinoma
Circulating miRNAs combined with AFP improve diagnostic accuracy for HBV-associated hepatocellular carcinoma Open
Background: Early detection of hepatocellular carcinoma (HCC) remains challenging due to the suboptimal diagnostic accuracy of alpha-fetoprotein (AFP). Circulating microRNAs (miRNAs), given their blood stability and role in cancer biology,…
View article: Prevalence of occult hepatitis B infection and hepatitis B genotype characterization among blood donors in Jember Regency, East Java, Indonesia
Prevalence of occult hepatitis B infection and hepatitis B genotype characterization among blood donors in Jember Regency, East Java, Indonesia Open
Background Despite extensive HBV vaccination efforts in Indonesia, the prevalence of occult hepatitis B virus infection (OBI) remains a concern, particularly among blood donors. This study investigated the prevalence of OBI, the distributi…
View article: Protective Role of the Sodium Taurocholate Cotransporting Polypeptide S267F Variant Against Hepatitis B Virus Infection and Cirrhosis in the Vietnamese Population
Protective Role of the Sodium Taurocholate Cotransporting Polypeptide S267F Variant Against Hepatitis B Virus Infection and Cirrhosis in the Vietnamese Population Open
The sodium taurocholate cotransporting polypeptide (NTCP) serves as both a hepatic bile acid transporter and an essential entry receptor for hepatitis B virus (HBV). The S267F (rs2296651) polymorphism in the NTCP gene has been associated w…
View article: Benign nature of incidental orbital uptake on bone scintigraphy: insights from multi- modality imaging and follow-up
Benign nature of incidental orbital uptake on bone scintigraphy: insights from multi- modality imaging and follow-up Open
Objective To characterize incidental orbital radionuclide uptake on bone scintigraphy using multi-modal imaging and follow-up. Methods This retrospective study included 66 patients with focal orbital uptake on whole-body bone scintigraphy …
View article: Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing <i>Pseudomonas aeruginosa</i>
Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing <i>Pseudomonas aeruginosa</i> Open
We evaluated the in vitro activity of cefiderocol in combination with either taniborbactam or xeruborbactam against cefiderocol-resistant, bla NDM -positive Pseudomonas aeruginosa clinical isolates from Vietnam and Nigeria. Taniborbactam r…
View article: Causative pathogens and predictors of unfavourable outcomes in central nervous system infections in resource-limited settings
Causative pathogens and predictors of unfavourable outcomes in central nervous system infections in resource-limited settings Open
View article: Dominance of DENV‐1 and Flavivirus Serological Cross‐Reactivity During the 2016 Dengue Outbreak in Vietnam
Dominance of DENV‐1 and Flavivirus Serological Cross‐Reactivity During the 2016 Dengue Outbreak in Vietnam Open
Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV) pose a major health burden in Vietnam, where overlapping clinical features and serological cross‐reactivity complicate accurate diagnosis an…
View article: Risk Stratification of Dengue Cases Requiring Hospitalization
Risk Stratification of Dengue Cases Requiring Hospitalization Open
Dengue pathogenesis involves immune‐driven inflammation that contributes to severe disease progression. This study assessed a machine learning model to identify a minimal, yet highly predictive biomarker set, aiming to support clinical dec…
View article: High Seroprevalence of Hepatitis E Virus Among Patients With Hepatitis B and Those With Hepatitis of Unknown Etiology in Central Vietnam
High Seroprevalence of Hepatitis E Virus Among Patients With Hepatitis B and Those With Hepatitis of Unknown Etiology in Central Vietnam Open
Background Hepatitis E virus (HEV) is a significant cause of acute viral hepatitis, particularly in regions with poor sanitation. Co-infection with hepatitis B virus (HBV) is common in high-risk populations, such as individuals with chroni…
View article: Susceptibility toward cefiderocol and sulbactam-durlobactam in extensively drug-resistant <i>Acinetobacter baumannii</i> detected from ICU admission screening in Hanoi, Vietnam, 2023
Susceptibility toward cefiderocol and sulbactam-durlobactam in extensively drug-resistant <i>Acinetobacter baumannii</i> detected from ICU admission screening in Hanoi, Vietnam, 2023 Open
Infections due to carbapenem-resistant Acinetobacter baumannii (CRAB) pose significant clinical challenges due to limited treatment options. In this study, we investigated the molecular epidemiology, resistance profiles, and genomic charac…
View article: Evaluating the Diagnostic Utility of 16S Oxford Nanopore Technology Sequencing in Patients With Central Nervous System Infections and Its Usefulness in Antimicrobial Stewardship
Evaluating the Diagnostic Utility of 16S Oxford Nanopore Technology Sequencing in Patients With Central Nervous System Infections and Its Usefulness in Antimicrobial Stewardship Open
Background Central nervous system (CNS) infections pose a significant public health challenge in resource-limited settings. Traditional culture-based and targeted molecular diagnostic methods have limitations in sensitivity and speed. This…
View article: Genomic analysis of carbapenemase-encoding plasmids and antibiotic resistance in carbapenem-resistant <i>Klebsiella pneumoniae</i> isolates from Vietnam, 2021
Genomic analysis of carbapenemase-encoding plasmids and antibiotic resistance in carbapenem-resistant <i>Klebsiella pneumoniae</i> isolates from Vietnam, 2021 Open
Carbapenem resistance in gram-negative rods is increasing in low- and middle-income countries. We conducted a single-center study to identify carbapenemase-encoding plasmids in carbapenem-resistant Klebsiella pneumoniae isolates causing hu…
View article: Characterization of dengue patients in Vietnam: Clinical, virological, and IL-10 profiles during 2021– 2022 outbreaks
Characterization of dengue patients in Vietnam: Clinical, virological, and IL-10 profiles during 2021– 2022 outbreaks Open
Background The pathogenesis of dengue is attributed to a complex interaction between the dengue virus (DENV) and the host immune system. The aim of this study is to investigate the clinical, virological, and Interleukin-10 (IL-10) profiles…
View article: Hepatitis E Virus Infection in Vietnamese Pregnant Women with Hepatitis B: Prevalence and Clinical Outcomes
Hepatitis E Virus Infection in Vietnamese Pregnant Women with Hepatitis B: Prevalence and Clinical Outcomes Open
Background Hepatitis E virus (HEV) infection during pregnancy is associated with obstetric complications and adverse maternal and neonatal outcomes. This study aimed to determine the seroprevalence of HEV and RNA positivity in both healthy…
View article: 18F-FDG PET/CT in the evaluation of femoral head osteonecrosis in patients with lymphoma
18F-FDG PET/CT in the evaluation of femoral head osteonecrosis in patients with lymphoma Open
Objective To describe the imaging features of osteonecrosis of the femoral head (ONFH) on fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT and explore the value of PET/CT in assessing ONFH in patients with lymphoma.Methods A …
View article: Epidemiology and Genotype Dynamics of Dengue in Hospitalized Patients in Northern Vietnam Between 2020 and 2022
Epidemiology and Genotype Dynamics of Dengue in Hospitalized Patients in Northern Vietnam Between 2020 and 2022 Open
Background Arboviruses, including Dengue (DENV), Zika, and chikungunya, cause recurrent outbreaks of varying intensity in tropical countries. This study aimed to investigate other arboviruses, including Zika and chikungunya, in patients cl…
View article: Evaluation of fibroinflammatory activity in thyroid eye disease using [18F]AlF-NOTA-FAPI-04 PET/CT: A prospective study
Evaluation of fibroinflammatory activity in thyroid eye disease using [18F]AlF-NOTA-FAPI-04 PET/CT: A prospective study Open
View article: Diagnostic challenges of arboviral infections and dengue virus serotype distribution in febrile patients in East Java, Indonesia
Diagnostic challenges of arboviral infections and dengue virus serotype distribution in febrile patients in East Java, Indonesia Open
View article: Supplementary Table 1 from Association Between Sleep Duration and Colorectal Adenomas: Findings from a Case-Control Study in Vietnam
Supplementary Table 1 from Association Between Sleep Duration and Colorectal Adenomas: Findings from a Case-Control Study in Vietnam Open
This supplementary table describes the distributions of baseline characteristics among study participants by cases versus controls
View article: Supplementary Table 1 from Association Between Sleep Duration and Colorectal Adenomas: Findings from a Case-Control Study in Vietnam
Supplementary Table 1 from Association Between Sleep Duration and Colorectal Adenomas: Findings from a Case-Control Study in Vietnam Open
This supplementary table describes the distributions of baseline characteristics among study participants by cases versus controls
View article: Data from Association Between Sleep Duration and Colorectal Adenomas: Findings from a Case-Control Study in Vietnam
Data from Association Between Sleep Duration and Colorectal Adenomas: Findings from a Case-Control Study in Vietnam Open
Background. Colorectal cancer (CRC) is one of the leading cancers worldwide and in Vietnam. Adenomas are important precursors of CRC. Study on the association between sleep duration and development of colorectal adenoma (CRA) is limited, p…
View article: Identification of breast cancer-associated PIK3CA H1047R mutation in blood circulation using an asymmetric PCR assay
Identification of breast cancer-associated PIK3CA H1047R mutation in blood circulation using an asymmetric PCR assay Open
Purpose To establish a highly sensitive and specific approach for the detection of circulating PIK3CA H1047R mutation in breast cancer (BC) patients and to investigate the association between the prevalence of PIK3CA H1047R mutation and cl…
View article: Characterization of zoonotic hepatitis E virus in domestic pigs and wild boar in Vietnam: Implications for public health
Characterization of zoonotic hepatitis E virus in domestic pigs and wild boar in Vietnam: Implications for public health Open
View article: Bone Marrow Necrosis with Underlying Skeletal Lymphoma Evaluated by 18F-FDG PET/CT and MRI
Bone Marrow Necrosis with Underlying Skeletal Lymphoma Evaluated by 18F-FDG PET/CT and MRI Open
Bone marrow necrosis (BMN) is usually associated with malignancies and is characterized by multiple geographic signal abnormalities on magnetic resonance imaging (MRI). We report a 28-year-old female with BMN and underlying diffuse large B…
View article: Multiple Bone Involvement in Low-grade Myofibroblastic Sarcoma Demonstrated on 18F-FDG PET/CT
Multiple Bone Involvement in Low-grade Myofibroblastic Sarcoma Demonstrated on 18F-FDG PET/CT Open
A 68-year-old woman with low back pain for 2 months was admitted. T2-weighted fat-saturated imaging revealed hyperintense lesions in multiple lumbar regions, suggesting the possibility of bone metastases. Multiple osteolytic and mixed oste…