Tho Huu Le
YOU?
Author Swipe
View article: Anti-tyrosinase activity of Curcuma aromatica ethyl acetate extract: from lead diarylheptanoids to melanogenesis targets
Anti-tyrosinase activity of Curcuma aromatica ethyl acetate extract: from lead diarylheptanoids to melanogenesis targets Open
Background Curcuma aromatica ( C. aromatica) , a traditional medicinal plant, holds promise for addressing oxidative stress and hyperpigmentation through its rich curcuminoid and polyphenol content. Building on our previous identification …
View article: Flavones from <i>Muntingia calabura</i> leaves: structural elucidation and SAR for α-glucosidase inhibition by <i>in vitro</i> and <i>in silico</i> evaluation
Flavones from <i>Muntingia calabura</i> leaves: structural elucidation and SAR for α-glucosidase inhibition by <i>in vitro</i> and <i>in silico</i> evaluation Open
Phytochemical investigation of Muntingia calabura leaves led to the isolation of three new calaburones (1–3) and 12 known flavones (4–15).
View article: <i>In vitro</i> and <i>in silico</i> hybrid approach to unveil triterpenoids from <i>Helicteres hirsuta</i> leaves as potential compounds for inhibiting Nrf2
<i>In vitro</i> and <i>in silico</i> hybrid approach to unveil triterpenoids from <i>Helicteres hirsuta</i> leaves as potential compounds for inhibiting Nrf2 Open
3β- O-trans -caffeoylbetulinic acid from Helicteres hirsuta inhibited Nrf2 in Huh7 with IC 50 of 74.5 μg mL −1 . Docking and dynamics simulations showed strong binding affinity of this compound and PI3Kα, an upstream modulator of Nrf2 in c…
View article: Isolation, structural elucidation, and integrated biological and computational evaluation of antidiabetic labdane diterpenes from <i>Curcuma zedoaria</i> rhizomes
Isolation, structural elucidation, and integrated biological and computational evaluation of antidiabetic labdane diterpenes from <i>Curcuma zedoaria</i> rhizomes Open
The phytochemical investigation of Curcuma zedoaria rhizomes revealed that a new norditerpene, zedolabdin A (CZ1), and coronarin C (CZ4) exhibited the most promising α-glucosidase inhibitory activity and favorable ADMET profiles, supportin…
View article: A new bicyclo [3.3.1]nonadienemethanol-type lignan from the leaves of <i>Taxus wallichiana</i> Zucc.
A new bicyclo [3.3.1]nonadienemethanol-type lignan from the leaves of <i>Taxus wallichiana</i> Zucc. Open
Following an α-glucosidase inhibitory activity-guided phytochemical study, a rare new bicyclo[3.3.1]nonadienemethanol-type lignan named 9,9′-oxidolanceolatanin B (1) and four known lignans, lanceolatanin B (2), pinoresinol (<…
View article: Identification of a new <i>α</i>‐glucosidase inhibitor: Alkyl ferulate ester derived from unripe fruits of <i>Solanum torvum</i> Swartz
Identification of a new <i>α</i>‐glucosidase inhibitor: Alkyl ferulate ester derived from unripe fruits of <i>Solanum torvum</i> Swartz Open
In this study, the phytochemical compositions and α ‐glucosidase inhibitory activity of the ethyl acetate extract derived from the unripe fruits of Solanum torvum Swartz have been investigated. The investigation led to the isolation of a n…
View article: Chemical constituents of the leaves of <i>Taxus wallichiana</i> (Taxaceae)
Chemical constituents of the leaves of <i>Taxus wallichiana</i> (Taxaceae) Open
From CHCl 3 ‐soluble extract of the leaves of Taxus wallichiana (Taxaceae), collected in Lam Dong Province, five compounds were isolated and identified as sciadopitysin ( 1 ), ginkgetin ( 2 ), ( S )‐(+)‐rhododenol ( 3 ), (+)‐ erythro ‐ N ‐…
View article: Melanogenesis inhibition activity of ethyl acetate fraction from Curcuma zedoaria in B16 cell line
Melanogenesis inhibition activity of ethyl acetate fraction from Curcuma zedoaria in B16 cell line Open
View article: <i>In vitro</i> biological evaluation and <i>in silico</i> studies of linear diarylheptanoids from <i>Curcuma aromatica</i> Salisb. as urease inhibitors
<i>In vitro</i> biological evaluation and <i>in silico</i> studies of linear diarylheptanoids from <i>Curcuma aromatica</i> Salisb. as urease inhibitors Open
This study reports nine new diarylheptanoids first isolated from the Curcuma aromatica Salisb., among which three are discovered for the first time, and two significantly inhibit urease, shedding light on its potential in treating gastric …
View article: A new apotirucallane-type protolimonoid from the leaves of <i>Paramignya trimera</i>
A new apotirucallane-type protolimonoid from the leaves of <i>Paramignya trimera</i> Open
This study presents a phytochemical analysis of the leaves of Paramignya trimera, revealing the isolation of a new apotirucallane-type protolimonoid, identified as 25-O-methyl-1,2-dihydroprotoxylocarpin D (1), along wi…
View article: Economic burden of Thalassemia treatment: An analysis from the Vietnam Social Security perspective
Economic burden of Thalassemia treatment: An analysis from the Vietnam Social Security perspective Open
Objectives Thalassemia is a genetic disorder that significantly impacts the health and well-being of individuals in Vietnam. This study aimed to assess the economic burden of Thalassemia treatment in Lam-Dong Province from the perspective …
View article: Chemical properties and inhibitory activities of tyrosinase, <i>α</i>‐glucosidase, and urease from chloroform extract of <i>Curcuma aromatica</i> Salisb. rhizomes
Chemical properties and inhibitory activities of tyrosinase, <i>α</i>‐glucosidase, and urease from chloroform extract of <i>Curcuma aromatica</i> Salisb. rhizomes Open
"Nghệ trắng" has the scientific name of Curcuma aromatica Salisb., belongs to the Ginger family (Zingiberaceae), and its rhizomes are used to prevent aging, anti‐inflammatory, and improve skin. From the chloroform extract of C. aromatica ,…
View article: Study on chemical composition and <i>α</i>‐glucosidase inhibitory activity from the leaves of <i>Muntingia calabura</i>
Study on chemical composition and <i>α</i>‐glucosidase inhibitory activity from the leaves of <i>Muntingia calabura</i> Open
“Trứng cá” ( Muntingia calabura ) is a special species of the genus Muntingia . Phytochemical studies on the leaves of M. calabura showed that seven compounds were isolated, including R ‐(+)‐ 5‐( δ ‐tocopherol‐5'‐yl)‐ δ ‐tocopherol ( 1 ), …
View article: Study on <i>α</i>‐glucosidase inhibitory activity of isolated flavones from genus <i>Artocarpus</i> and their enzyme kinetics
Study on <i>α</i>‐glucosidase inhibitory activity of isolated flavones from genus <i>Artocarpus</i> and their enzyme kinetics Open
Flavonoids are the major compounds associated with diverse bioactivities, especially with α ‐glucosidase inhibitory activity related to diabetes mellitus. The study reported the α ‐glucosidase inhibitory activity of seventeen flavonoids is…
View article: Two new phenylbutenoids from the rhizomes of cassumunar ginger and their <i>α</i> -glucosidase inhibitory activity
Two new phenylbutenoids from the rhizomes of cassumunar ginger and their <i>α</i> -glucosidase inhibitory activity Open
An extract from the rhizomes of Cassumunar ginger (Zingiber purpureum Roscoe). was found to have significant α-glucosidase inhibitory activity with an IC50 value of 6.3 µg/mL. Two new phenylbutenoids, cassud…
View article: Strebluses E–H, four new stilbene-like derivatives from the stems of <i>Streblus ilicifolius</i>
Strebluses E–H, four new stilbene-like derivatives from the stems of <i>Streblus ilicifolius</i> Open
Streblus E was a potent tyrosinase inhibitor isolated from the stems of Streblus ilicifolius . Its docking study with oxy-tyrosinase was carried out to clarify their interactive model.
View article: Paratrimerin Z, an undescribed chromene derivative from the roots of <i>Paramignya trimera</i>
Paratrimerin Z, an undescribed chromene derivative from the roots of <i>Paramignya trimera</i> Open
From an EtOAc-soluble fraction of the roots of Paramignya trimera, one undescribed chromene derivative, paratrimerin Z (1), was isolated. Its structure was elucidated on the basis of NMR spectroscopic interpretation. The abso…
View article: A New Dimeric Lignan from the Stems of Willughbeia edulis
A New Dimeric Lignan from the Stems of Willughbeia edulis Open
As part of our continued study on the chemical constituents of Willughbeia edulis stems, a new dimeric lignan named edulignan (1) was isolated from its EtOAc-soluble extract. Based on NMR spectroscopic interpretation, the planar structure …
View article: Lignans from the fruits of Pandanus kaida Kurz. (Pandanaceae) and theirs a-Glucosidase inhibitory activities
Lignans from the fruits of Pandanus kaida Kurz. (Pandanaceae) and theirs a-Glucosidase inhibitory activities Open
Pandanus kaida Kurz is a arbsute, which is combined with others medical plants for treatment of kidney stones, epididymitis and eyes diseases in Vietnamese traditional medicines. However, little scientific publication is available for this…
View article: Olean-type triterpenoids from the stems of Salacia chinensis L. (Celastraceae) and theira-glucosidase inhibitory activities
Olean-type triterpenoids from the stems of Salacia chinensis L. (Celastraceae) and theira-glucosidase inhibitory activities Open
In this paper, chemical constituents from the stems of Salacia chinensis L. (Celastraceae) and evaluating their a-glucosidase inhibitory activity were reported. Our study provides more information to the Vietnamese medical plants database.…
View article: Some compounds from the rhizome of Zingiber montanum
Some compounds from the rhizome of Zingiber montanum Open
Ngai say vang has the scientific name Zingiber montanum or synonym Zingiber cassumunar Roxb. belongs to the Ginger family (Zingiberaceae). The tree is native to India and suitable for the humid tropical climate of Asian countries. In Vietn…
View article: Tyrosinase Inhibitors from the Stems of Streblus Ilicifolius
Tyrosinase Inhibitors from the Stems of Streblus Ilicifolius Open
Two new stilbene derivatives, named strebluses C and D, were isolated from the EtOAc-soluble fraction of the stems of Streblus ilicifolius (Moraceae). Its absolute configuration was elucidated based on NMR spectroscopic data interpretation…
View article: Chemical constituents and their alpha-glucosidase inhibitory activity from the stems of taxotrophis ilicifolius
Chemical constituents and their alpha-glucosidase inhibitory activity from the stems of taxotrophis ilicifolius Open
Taxotrophis ilicifolius, called "Gai quít" in Vietnam, belonged to the family of Moraceae. The stems of T. ilicifolius are used in traditional medicine to cure pimples, anti-inflammatory, antibacterial... By column chromatography method to…
View article: Chemical constituents and their alpha-glucosidase inhibitory activity of Solanum procumbens
Chemical constituents and their alpha-glucosidase inhibitory activity of Solanum procumbens Open
Solanum procumbens called ``Cà gai leo'' in Vietnam, belonged to the family of Solanaceae, which is a prickly diffuse, bright green perennial shrub, woody at the base. This plant has been sought for plenty of Vietnamese folk remedies for d…
View article: Hepatitis B virus infection among pregnant mothers and children after the introduction of the universal vaccination program in Central Vietnam
Hepatitis B virus infection among pregnant mothers and children after the introduction of the universal vaccination program in Central Vietnam Open
View article: Chemical constituents of the Rhizomes of Curcuma zedoaria
Chemical constituents of the Rhizomes of Curcuma zedoaria Open
Curcuma zedoaria (Berg.), belongs to the Zingiberaceae family, is one of the medicinal plants that is found in Southeast Asia. This plant is known as “Nghe tim” in Vietnam; and a decoction of its rhizomes has been used traditionally for th…
View article: Diarylalkanoids as Potent Tyrosinase Inhibitors from the Stems of Semecarpus caudata
Diarylalkanoids as Potent Tyrosinase Inhibitors from the Stems of Semecarpus caudata Open
From a CHCl3-soluble extract of the stems of Semecarpus caudata (Anacardiaceae), two new diarylalkanoids, semedienone (1) and semetrienone (2), were isolated. Their structures were elucidated based on NMR spectroscopic data interpretation.…
View article: A new phenylheptanoid from the leaves of <i>Gnetum gnemon</i> L.
A new phenylheptanoid from the leaves of <i>Gnetum gnemon</i> L. Open
Phytochemical study on the EtOAC-soluble extract of the leaves of Gnetum gnemon furnished the isolation of a new phenylheptanoid, gnetumal (1), along with five known compounds (2–6). Their isolation was carried …
View article: Chemical constituents of the leave of Gnetum gnemon L.
Chemical constituents of the leave of Gnetum gnemon L. Open
(Vietnamese name; L.), which belongs to the family, is an evergreen and perennial tree that is widely cultivated in Southeast Asia. In Vietnam, leaves of the species are used as an ordinary vegetable in many regions. The aim of this resear…
View article: Study on structure–activity relationships (SARs) of epoxylignan compounds with α- glucosidase inhibitory activity
Study on structure–activity relationships (SARs) of epoxylignan compounds with α- glucosidase inhibitory activity Open
Epoxylignans are polyphenolic compounds, which possess various biological activities such as antiproliferative activity on cancer cells, antioxidant, antihyperglycemic,… In this research, we study on α- glucosidase inhibitory activity of 1…