Jennifer Lê
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View article: A Multicenter, Open-Label Study of Combined Poly-L-Lactic Acid and Hyaluronic Midface Filler Regimen Enhances Facial Harmony and Skin Quality in GLP-1 Medication Users
A Multicenter, Open-Label Study of Combined Poly-L-Lactic Acid and Hyaluronic Midface Filler Regimen Enhances Facial Harmony and Skin Quality in GLP-1 Medication Users Open
Background Weight loss induced by glucagon-like peptide-1 receptor agonists (GLP-1 RAs) can lead to facial volume loss, wrinkles, and sagging skin, resulting in an aged and gaunt appearance that negatively affects subject satisfaction and …
View article: Patterns of restricted TCR usage following SARS-CoV-2 vaccination and severe disease
Patterns of restricted TCR usage following SARS-CoV-2 vaccination and severe disease Open
Introduction T cells influence COVID-19 severity and establish long-lasting immune memory in response to vaccination and infection. The diversity of the T cell repertoire, and complexity of T cell epitope recognition, make it challenging t…
View article: SAT-393 Physiology Of A Thyroidally-Derived T3-Centric Hormonal Environment
SAT-393 Physiology Of A Thyroidally-Derived T3-Centric Hormonal Environment Open
Disclosure: C.E. Citterio: None. B. Morales-Rodriguez: None. X. Liao: None. C. Vu: None. R. Nguyen: None. J. Tsai: None. J. Le: None. I. Metawea: None. M. Liu: None. D.P. Olson: None. S. Refetoff: None. P. Arvan: None. Thyroid hormones (T4…
View article: A Genetically-Engineered Thyroid Gland Built for Selective Triiodothyronine Secretion
A Genetically-Engineered Thyroid Gland Built for Selective Triiodothyronine Secretion Open
Thyroid hormones (thyroxine, T4, and triiodothyronine, T3) are indispensable for sustaining vertebrate life, and their deficiency gives rise to a wide range of symptoms characteristic of hypothyroidism, affecting 5–10% of the world’s popul…
View article: Current state of microbiota clinical applications in neonatal and pediatric bacterial infections
Current state of microbiota clinical applications in neonatal and pediatric bacterial infections Open
The microbiota plays a crucial role in pediatric health by shaping immune development and influencing infection susceptibility. In infants and children, an immature microbiota may compromise immune defense, increasing the risk of bacterial…
View article: Dosing Recommendations for Ampicillin and Ceftriaxone in the Treatment of Pediatric Community-Acquired Pneumonia Using Monte Carlo- and Physiologic-Based Pharmacokinetic Simulations
Dosing Recommendations for Ampicillin and Ceftriaxone in the Treatment of Pediatric Community-Acquired Pneumonia Using Monte Carlo- and Physiologic-Based Pharmacokinetic Simulations Open
OBJECTIVE Since 2011, Ampicillin (AMP) has been recommended as the parenteral antibiotic of choice for pediatric community-acquired pneumonia (CAP), but ceftriaxone (CRO) is recommended for unvaccinated children and those with complicated …
View article: Variability in Meropenem Distribution and Clearance in Children with Sepsis: Population-Based Pharmacokinetics with Assessment of Renal Biomarkers
Variability in Meropenem Distribution and Clearance in Children with Sepsis: Population-Based Pharmacokinetics with Assessment of Renal Biomarkers Open
Wide variation in meropenem concentrations in children with sepsis as compared to those without sepsis prompt close monitoring of GFR and drug concentrations in this population.
View article: C-ARM Guidance: A Self-Supervised Approach to Automated Positioning During Stroke Thrombectomy
C-ARM Guidance: A Self-Supervised Approach to Automated Positioning During Stroke Thrombectomy Open
Thrombectomy is one of the most effective treatments for ischemic stroke, but it is resource and personnel-intensive. We propose employing deep learning to automate critical aspects of thrombectomy, thereby enhancing efficiency and safety.…
View article: Evaluating a Tobacco-free Policy Intervention in Residential Substance Use Disorder Programs
Evaluating a Tobacco-free Policy Intervention in Residential Substance Use Disorder Programs Open
Introduction: Individuals in treatment for substance use disorders (SUD) use tobacco at much higher rates than the general population. Qualitative research can help identify successful implementation approaches for tobacco-free policy inte…
View article: Subtherapeutic Meropenem Antibiotic Exposure in Children With Septic Shock Assessed by Noncompartmental Pharmacokinetic Analysis in a Prospective Dataset
Subtherapeutic Meropenem Antibiotic Exposure in Children With Septic Shock Assessed by Noncompartmental Pharmacokinetic Analysis in a Prospective Dataset Open
OBJECTIVES: To define meropenem plasma concentrations and pharmacodynamic exposure metrics in children with septic shock during the first 3 days of PICU hospitalization. DESIGN: Pharmacokinetic sampling was undertaken in 19 subjects receiv…
View article: Midface Projection Using Biostimulatory Poly-l-Lactic Acid Injectable Implant: A Subgroup Analysis of the Cheek Wrinkle Trial
Midface Projection Using Biostimulatory Poly-l-Lactic Acid Injectable Implant: A Subgroup Analysis of the Cheek Wrinkle Trial Open
BACKGROUND Correction of cheek wrinkles using poly- l -lactic acid (PLLA-SCA) was demonstrated in a 12-month study. OBJECTIVE This analysis assessed change from baseline in lifting effect of PLLA-SCA using a 3D camera to provide additional…
View article: Antifibrinolytic and Adjunct Hemostatic Agents: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference
Antifibrinolytic and Adjunct Hemostatic Agents: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference Open
OBJECTIVES: To derive systematic-review informed, modified Delphi consensus regarding antifibrinolytic and adjunct hemostatic agents in neonates and children supported with extracorporeal membrane oxygenation (ECMO) for the Pediatric ECMO …
View article: Executive Summary: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE (PEACE) Consensus Conference*
Executive Summary: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE (PEACE) Consensus Conference* Open
OBJECTIVES: To present recommendations and consensus statements with supporting literature for the clinical management of neonates and children supported with extracorporeal membrane oxygenation (ECMO) from the Pediatric ECMO Anticoagulati…
View article: Anticoagulant Medications: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference
Anticoagulant Medications: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference Open
OBJECTIVES: To derive systematic-review informed, modified Delphi consensus regarding the medications used for anticoagulation for pediatric extracorporeal membrane oxygenation (ECMO) for the Pediatric ECMO Anticoagulation CollaborativE (P…
View article: Racial Health Disparity Associated With Poor Pediatric Cardiac Surgery Outcomes
Racial Health Disparity Associated With Poor Pediatric Cardiac Surgery Outcomes Open
The influence of racial differences in neonates and children should be further evaluated to mitigate any disparity in those undergoing cardiac surgery.
View article: Establishment of a Four‐Cell <i>In Vitro</i> Blood‐Brain Barrier Model With Human Primary Brain Cells
Establishment of a Four‐Cell <i>In Vitro</i> Blood‐Brain Barrier Model With Human Primary Brain Cells Open
The blood‐brain barrier (BBB) constitutes a crucial protective anatomical layer with a microenvironment that tightly controls material transit. Constructing an in vitro BBB model to replicate in vivo features requires the sequential layeri…
View article: Issue Information
Issue Information Open
Using popula on pharmacokine cs to op mize ini al vancomycin dosing
View article: 2551. Assessing Meropenem Concentrations in Children with Septic Shock: Population-Based Pharmacokinetic (PK) Modeling of Meropenem Demonstrates Variability from Acute Kidney (AKI) to Augmented Renal Clearance (ARC)
2551. Assessing Meropenem Concentrations in Children with Septic Shock: Population-Based Pharmacokinetic (PK) Modeling of Meropenem Demonstrates Variability from Acute Kidney (AKI) to Augmented Renal Clearance (ARC) Open
Background The primary objective of this study was to characterize meropenem (MERO) pharmacokinetics (PK) in critically ill infants and children with septic shock to develop dosing recommendations to achieve therapeutic drug exposure in th…
View article: Chemotherapy in pediatric brain tumor and the challenge of the blood–brain barrier
Chemotherapy in pediatric brain tumor and the challenge of the blood–brain barrier Open
Background Pediatric brain tumors (PBT) stand as the leading cause of cancer‐related deaths in children. Chemoradiation protocols have improved survival rates, even for non‐resectable tumors. Nonetheless, radiation therapy carries the risk…