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View article: In vitro α-Glucosidase inhibitors of Polyscias serrata Roots in a Parallel Study of Network Pharmacology
In vitro α-Glucosidase inhibitors of Polyscias serrata Roots in a Parallel Study of Network Pharmacology Open
View article: Flavonoids from <i>Alpinia vietnamica</i>, and their cytotoxic, antioxidative, and <i>α</i>‐glucosidase inhibitory activities
Flavonoids from <i>Alpinia vietnamica</i>, and their cytotoxic, antioxidative, and <i>α</i>‐glucosidase inhibitory activities Open
Phytochemical research of the 80% EtOH whole plant extract of Alpinia vietnamica H.Ð. Tran, Luu & Skornick resulted in the isolation and structural elucidation of seven compounds 1–7 , including two flavones quercetin‐3‐ O ‐ α ‐ l ‐rhamnos…
View article: Essential Oils of <i>Alpinia vietnamica</i> Rhizomes and Leaves: Chemical Composition, Cytotoxicity, α-Glucosidase Inhibition, and Molecular Docking Approach
Essential Oils of <i>Alpinia vietnamica</i> Rhizomes and Leaves: Chemical Composition, Cytotoxicity, α-Glucosidase Inhibition, and Molecular Docking Approach Open
Objective: Alpinia is a big genus of flowering plants in the family Zingiberaceae. The plants of this genus are generally aromatic due to their essential oils. The current study aims to identify chemical compositions in the rhizome and lea…
View article: Phytochemical investigation and antimicrobial activity from rhizomes of alocasia odora K. Koch
Phytochemical investigation and antimicrobial activity from rhizomes of alocasia odora K. Koch Open
Alocasia odora is a common plant species in Viet Nam. A phytochemical investigation of the ethyl acetate extract (EtOAc) of A. odora rhizomes collected in Tuyen Quang province led to the isolation and determination of five compounds, inclu…
View article: Synthesis and Cytotoxic Evaluation of Fluoro and Trifluoromethyl Substituents Containing Novel Naphthoquinone-Fused Podophyllotoxins
Synthesis and Cytotoxic Evaluation of Fluoro and Trifluoromethyl Substituents Containing Novel Naphthoquinone-Fused Podophyllotoxins Open
A series of novel naphthoquinone-fused podophyllotoxins containing fluoro and trifluoromethyl substituents were synthesized in a medium with good yields using two different synthetic approaches: microwave-assisted four-component reactions …
View article: Bannaxanthone E Induced Cell-Cycle Arrest and Apoptosis in Human Lung Cancer Cell Line
Bannaxanthone E Induced Cell-Cycle Arrest and Apoptosis in Human Lung Cancer Cell Line Open
The anti-cancer activity of bannaxanthone E isolated from Garcinia mckeaniana leaves was assessed through a flow cytometric method on human lung SK-LU-1 cancer cells, including cell cycle changes and induction of cell apoptosis. Treatment …
View article: Synthesis and alpha ‐ inhibitory activity of lupane type <scp>С2</scp>‐benzylidene‐ triterpenoids
Synthesis and alpha ‐ inhibitory activity of lupane type <span>С2</span>‐benzylidene‐ triterpenoids Open
A series of novel and previously synthesized lupane type С2‐benzylidene derivatives was evaluated on α ‐glucosidase enzyme inhibition. Most of the tested compounds exhibited significantly better activity (1.8‐700 times higher) than the sta…
View article: chemical constituents from methanolic extract of Garcinia mackeaniana leaves and their antioxidant activity
chemical constituents from methanolic extract of Garcinia mackeaniana leaves and their antioxidant activity Open
A phytochemical investigation of the methanolic extract of Garcinia mackeaniana leaves led to the isolation, and determination of five secondary metabolites, including one benzophenone 4,3',4'-trihydroxy-2,6-dimethoxybenzophenone (1), two …
View article: Antimicrobacterial xanthones from <i>Garcinia mackeaniana</i> leaves
Antimicrobacterial xanthones from <i>Garcinia mackeaniana</i> leaves Open
A phytochemical study of the EtOAc extract of Garcinia mackeaniana leaves has resulted in the isolation and determination of five xanthones, consisting of norathyriol ( 1 ), mangiferin ( 2 ), allanxanthone C ( 3 ), garcinone E ( 4 ), and b…
View article: A New Benzofuran Derivative From the Stems of <i>Helicteres hirsuta</i>
A New Benzofuran Derivative From the Stems of <i>Helicteres hirsuta</i> Open
A new benzofurane 7-methoxy-2-(3-hydroxy-4-methoxyphenyl)-benzofuran-5-carboxylate (1) and 5 known compounds, such as propacin (2), hisbiscolatone A (3), heliclactone (4), rosmarinic acid (5), and syringaldehyde (6), were isolated from met…
View article: Synthesis and Cytotoxic Evaluation of Carboxylic Acid-Functionalized Indenoisoquinolines
Synthesis and Cytotoxic Evaluation of Carboxylic Acid-Functionalized Indenoisoquinolines Open
In order to find out the influence of carboxylic acid functionalities in the N-lactam side chains of indenoisoquinolines on cytotoxic activities, several new compounds have been synthesized and structurally characterized by analytical and …
View article: Design, Synthesis and Cytotoxic Evaluation of 4-Anilinoquinazoline– triazole–AZT Hybrids as Anticancer Agents
Design, Synthesis and Cytotoxic Evaluation of 4-Anilinoquinazoline– triazole–AZT Hybrids as Anticancer Agents Open
A series of 4-anilinoquinazoline–triazole–AZT hybrids were designed and synthesized as anticancer agents. Their cytotoxic potential has been evaluated by means of a micro-dilution assay against three human cancer cell lines (KB, epidermoid…
View article: Synthesis of New Simplified and Racemic <i>Hemiasterlin</i> Derivatives with Extremely High Cytotoxicity
Synthesis of New Simplified and Racemic <i>Hemiasterlin</i> Derivatives with Extremely High Cytotoxicity Open
Hemiasterlin is a potent antimitotic agent acting through inhibition of microtubule depolymerization. For this reason, the synthesis of new hemiasterlin derivatives has attracted a lot of interest in the organic chemistry community recentl…
View article: Synthesis and Cytotoxic Evaluation of Artemisinin Derivatives Containing an Aminopropanol Group
Synthesis and Cytotoxic Evaluation of Artemisinin Derivatives Containing an Aminopropanol Group Open
Series of novel artemisinin derivatives were designed and synthesized in which the amino propanol group was bonded to the artemisinin nucleus through C-C linkage. Ten new compounds were thus successfully prepared and evaluated as cytotoxic…