Yunle Wan
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View article: Backstepping-based consensus control method for gliding aircraft formation
Backstepping-based consensus control method for gliding aircraft formation Open
This paper proposes a formation control method for gliding aircraft based on backstepping consensus control. The method ensures stable formation maintenance and smooth transitions in both altitude and lateral directions while meeting termi…
View article: The triglyceride-glucose index associated with reduced risk of liver metastasis in pancreatic cancer
The triglyceride-glucose index associated with reduced risk of liver metastasis in pancreatic cancer Open
Background The triglyceride-glucose (TyG) index has emerged as a reliable surrogate marker for insulin resistance and is associated with multiple malignancies. However, its role in pancreatic cancer liver metastasis (PCLM) remains unclear.…
View article: Donor liver natural killer cells ameliorate liver allograft rejection via inducing apoptosis of alloreactive CD8+ T cells generating CD4+CD25+ regulatory T cells
Donor liver natural killer cells ameliorate liver allograft rejection via inducing apoptosis of alloreactive CD8+ T cells generating CD4+CD25+ regulatory T cells Open
The roles of donor liver natural killer (NK) cells in allogeneic liver transplantation remains controversial. Herein, we investigated the effects of liver NK cells on liver allograft tolerance by using liver NK cells and allogeneic spleen …
View article: Determinants of clinical success and complications in fluoroscopy-guided self-expandable metal stent for treatment of malignant rectal obstruction
Determinants of clinical success and complications in fluoroscopy-guided self-expandable metal stent for treatment of malignant rectal obstruction Open
For MRO patients, SEMS constitutes an efficacious and successful therapeutic approach. Prompt alleviation of the obstruction is associated with a high rate of clinical success and a reduced incidence of short-term complications. Furthermor…
View article: Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation (2024 edition)
Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation (2024 edition) Open
The formulation of these guidelines represents a significant advancement towards standardizing minimally invasive liver transplantation surgeries in China. They are designed to enhance outcomes for both donors and recipients by synthesizin…
View article: Risk factors, prognostic factors, and nomograms for liver metastasis in patients with stage T is -T 2 colorectal cancer: a population-based study
Risk factors, prognostic factors, and nomograms for liver metastasis in patients with stage T is -T 2 colorectal cancer: a population-based study Open
Background: Liver metastasis(LM) is the primary cause of mortality in patients with colorectal cancer. The incidence of liver metastasis in patients with stage Tis-T2 colorectal cancer is uncommon, and there is limited research available. …
View article: Donor liver natural killer cells ameliorate liver allograft rejection via inducing apoptosis of alloreactive CD8 + T cells and generating CD4 + CD25 + regulatory T cells
Donor liver natural killer cells ameliorate liver allograft rejection via inducing apoptosis of alloreactive CD8 + T cells and generating CD4 + CD25 + regulatory T cells Open
The roles of donor liver natural killer (NK) cells in allogeneic liver transplantation remains controversial. Herein, we investigated the effects of liver NK cells on liver allograft tolerance by using liver NK cells and allogeneic spleen …
View article: Cathepsins Influence Metastatic Liver Cancer via Plasma Proteins: a Mendelian randomization Study
Cathepsins Influence Metastatic Liver Cancer via Plasma Proteins: a Mendelian randomization Study Open
Background: Cathepsins (CTSs), lysosomal cysteine proteases, have been reported to play roles in the initiation, infiltration, and dissemination of tumors in previous researches. However, the precise causal relationship between CTSs and me…
View article: The neutrophil-to-lymphocyte ratio and lactate dehydrogenase combined in predicting liver metastasis and prognosis of colorectal cancer
The neutrophil-to-lymphocyte ratio and lactate dehydrogenase combined in predicting liver metastasis and prognosis of colorectal cancer Open
Background The neutrophil-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) level are inflammatory markers related to tumor growth and metabolism. This study investigated the value of preoperative NLR, LDH and the combination of NL…
View article: Microbial spectrum and drug resistance of pathogens cultured from gallbladder bile specimens of patients with cholelithiasis: A single-center retrospective study
Microbial spectrum and drug resistance of pathogens cultured from gallbladder bile specimens of patients with cholelithiasis: A single-center retrospective study Open
The presence of common bile duct stones and longer operation time were identified as independent risk factors for positive bile culture in patients with cholelithiasis. The most commonly detected bacterium was E. coli. The combination of β…
View article: Survival benefit of primary tumor resection for gastric cancer with liver metastasis: A propensity score-matched, population-based study
Survival benefit of primary tumor resection for gastric cancer with liver metastasis: A propensity score-matched, population-based study Open
Objectives Gastric cancer with liver metastasis (GCLM) is highly aggressive and has a poor prognosis. This study aims to evaluate the survival benefit of primary tumor resection (PTR) for gastric cancer with liver metastasis. Methods Data …
View article: MiR-195-5p suppresses the proliferation, migration, and invasion of gallbladder cancer cells by targeting FOSL1 and regulating the Wnt/β-catenin pathway
MiR-195-5p suppresses the proliferation, migration, and invasion of gallbladder cancer cells by targeting FOSL1 and regulating the Wnt/β-catenin pathway Open
The overexpression of miR-195-5p inhibits the proliferation and metastasis of GBC cells by directly targeting FOSL1 and regulating the Wnt/β-catenin signaling pathway.
View article: mFOLFOXIRI with or without bevacizumab for conversion therapy of RAS/BRAF/PIK3CA mutant unresectable colorectal liver metastases: the FORBES non-randomized phase II trial
mFOLFOXIRI with or without bevacizumab for conversion therapy of RAS/BRAF/PIK3CA mutant unresectable colorectal liver metastases: the FORBES non-randomized phase II trial Open
We observed that the combination of mFOLFOXIRI and bevacizumab increased the rate of clinical NED and showed a trend toward improved survival compared with mFOLFOXIRI alone. This could represent a conversion therapy option for fit patients…
View article: LncRNA HOXB-AS3 Promotes Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition of Gallbladder Cancer Cells by Activating the MEK/ERK Pathway
LncRNA HOXB-AS3 Promotes Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition of Gallbladder Cancer Cells by Activating the MEK/ERK Pathway Open
OBJECTIVE: Long non-coding RNA HOXB-AS3 has been implicated in tumor progression in a variety of carcinomas. However, its biological role in gallbladder cancer (GBC) is unknown. The biological function and underlying mechanism of the lncRN…
View article: The prognostic value of preoperative serum lactate dehydrogenase levels in patients underwent curative‐intent hepatectomy for colorectal liver metastases: A two‐center cohort study
The prognostic value of preoperative serum lactate dehydrogenase levels in patients underwent curative‐intent hepatectomy for colorectal liver metastases: A two‐center cohort study Open
Background The prognostic value of lactate dehydrogenase (LDH) in colorectal cancer patients has remained inconsistent between nonmetastatic and metastatic settings. So far, very few studies have included LDH in the prognostic analysis of …
View article: The Prognostic Value of Preoperative Serum Lactate Dehydrogenase (LDH) Levels in Patients Underwent Curative-intent Hepatectomy For Colorectal Liver Metastases: A Two-Center Cohort Study
The Prognostic Value of Preoperative Serum Lactate Dehydrogenase (LDH) Levels in Patients Underwent Curative-intent Hepatectomy For Colorectal Liver Metastases: A Two-Center Cohort Study Open
Background. The prognostic value of lactate dehydrogenase (LDH) in colorectal cancer patients has remained inconsistent between non-metastatic and metastatic settings. So far, very few studies have included LDH in the prognostic analysis o…
View article: The Prognostic Value of Preoperative Serum Lactate Dehydrogenase (LDH) Levels in Patients Underwent Curative-intent Hepatectomy For Colorectal Liver Metastases: A Two-Center Cohort Study
The Prognostic Value of Preoperative Serum Lactate Dehydrogenase (LDH) Levels in Patients Underwent Curative-intent Hepatectomy For Colorectal Liver Metastases: A Two-Center Cohort Study Open
Background: The prognostic value of lactate dehydrogenase (LDH) in colorectal cancer patients has remained inconsistent between non-metastatic and metastatic settings. So far very few studies have included LDH in prognostic analysis for pa…
View article: Modified FOLFOXIRI With or Without Cetuximab as Conversion Therapy in Patients with <i>RAS</i>/<i>BRAF</i> Wild-Type Unresectable Liver Metastases Colorectal Cancer: The FOCULM Multicenter Phase II Trial
Modified FOLFOXIRI With or Without Cetuximab as Conversion Therapy in Patients with <i>RAS</i>/<i>BRAF</i> Wild-Type Unresectable Liver Metastases Colorectal Cancer: The FOCULM Multicenter Phase II Trial Open
Purpose This trial evaluated the addition of cetuximab to a modified FOLFOXIRI (mFOLFOXIRI: 5-fluorouracil/folinic acid, oxaliplatin, irinotecan) as conversion therapy in a two-group, nonrandomized, multicenter, phase II trial in patients …
View article: MicroRNA-421 Inhibits Apoptosis by Downregulating Caspase-3 in Human Colorectal Cancer
MicroRNA-421 Inhibits Apoptosis by Downregulating Caspase-3 in Human Colorectal Cancer Open
Yifan Zhou,1,* Xiaowen Cheng,1,2,* Yufeng Wan,3,* Tingting Chen,4 Qing Zhou,2 Zhengguang Wang,5 Huaqing Zhu2 1Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People&rsq…
View article: SRF Potentiates Colon Cancer Metastasis and Progression in a microRNA-214/PTK6-Dependent Manner
SRF Potentiates Colon Cancer Metastasis and Progression in a microRNA-214/PTK6-Dependent Manner Open
Tao Li,1,* Yingchun Wan,2,* Ziyuan Su,3 Jiayu Li,4 Minna Han,5 Changyu Zhou6 1Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, People’s Republic of China; 2Department of Endocrinology, …
View article: Increase in CD4+FOXP3+ regulatory T cell number and upregulation of the HGF/c‑Met signaling pathway during the liver metastasis of colorectal cancer
Increase in CD4+FOXP3+ regulatory T cell number and upregulation of the HGF/c‑Met signaling pathway during the liver metastasis of colorectal cancer Open
Colorectal cancer (CRC) is the third and second most common type of cancer diagnosed in males and females, respectively, and is the fourth leading cause of cancer-associated mortality worldwide. Liver metastasis is the primary cause of mor…
View article: The lncRNA NORAD/miR-520a-3p Facilitates Malignancy in Non-Small Cell Lung Cancer via PI3k/Akt/mTOR Signaling Pathway
The lncRNA NORAD/miR-520a-3p Facilitates Malignancy in Non-Small Cell Lung Cancer via PI3k/Akt/mTOR Signaling Pathway Open
Yunyan Wan, Zhouhong Yao, Weijuan Chen, Dezhi Li Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, People’s Republic of ChinaCorrespondence: …
View article: Antitumor immunity of low-dose cyclophosphamide: changes in T cells and cytokines TGF-beta and IL-10 in mice with colon-cancer liver metastasis
Antitumor immunity of low-dose cyclophosphamide: changes in T cells and cytokines TGF-beta and IL-10 in mice with colon-cancer liver metastasis Open
Background The tumor immune microenvironment is one of the most important prognostic factors in liver metastasis from colorectal cancer. Low-dose cyclophosphamide (CTX) is widely believed to be involved in the modulation of the immune syst…