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View article: Chlorinephenyl‐Substituted Sulfonylurea Confer Inhibitory Efficacy against Metallo‐β‐lactamase ImiS
Chlorinephenyl‐Substituted Sulfonylurea Confer Inhibitory Efficacy against Metallo‐β‐lactamase ImiS Open
Super bacterial infection caused by metallo‐β‐lactamases (MβLs) has posed a serious public health threat, while developing inhibitors of MβLs is an ideal strategy to combat drug‐resistance. Here, seventeen sulfonylureas were synthesized an…
View article: A Modified Vancomycin Molecule Confers Potent Inhibitory Efficacy against Resistant Bacteria Mediated by Metallo-β-Lactamases
A Modified Vancomycin Molecule Confers Potent Inhibitory Efficacy against Resistant Bacteria Mediated by Metallo-β-Lactamases Open
Multidrug-resistant bacterial infections mediated by metallo-β-lactamases (MβLs) have grown into an emergent health threat, and development of novel antimicrobials is an ideal strategy to combat the infections. Herein, a novel vancomycin d…
View article: Structure‐based analysis and evolution of a monomerized red‐colored chromoprotein from the <i>Olindias formosa</i> jellyfish
Structure‐based analysis and evolution of a monomerized red‐colored chromoprotein from the <i>Olindias formosa</i> jellyfish Open
GFP‐like chromoproteins (CPs) with non‐fluorescence ability have been used as bioimaging probes. Existing CPs have voids in the optical absorption window which limits their extensibility. The development of new CP color is therefore ongoin…
View article: Current Research Status on Cold Sprayed Amorphous Alloy Coatings: A Review
Current Research Status on Cold Sprayed Amorphous Alloy Coatings: A Review Open
Compared with traditional crystalline materials, amorphous alloys have excellent corrosion and wear resistance and high elastic modulus, due to their unique short-range ordered and long-range disordered atomic arrangement as well as absenc…
View article: Cyanate ester resin based composites with high toughness and thermal conductivity
Cyanate ester resin based composites with high toughness and thermal conductivity Open
h-BN particles were used to fabricate cyanate ester/core–shell structured polyacrylic/BN composites. The impact strength and the thermal conductivity of the composites were simultaneously increased, which may be used in microelectronic pac…
View article: Triazolylthioacetamide: A Valid Scaffold for the Development of New Delhi Metallo-β-Lactmase-1 (NDM-1) Inhibitors
Triazolylthioacetamide: A Valid Scaffold for the Development of New Delhi Metallo-β-Lactmase-1 (NDM-1) Inhibitors Open
The metallo-β-lactamases (MβLs) cleave the β-lactam ring of β-lactam antibiotics, conferring resistance against these drugs to bacteria. Twenty-four triazolylthioacetamides were prepared and evaluated as inhibitors of representatives of th…