Yong Xu
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View article: Combining Knowledge Graph and LLMs for Enhanced Zero-shot Visual Question Answering
Combining Knowledge Graph and LLMs for Enhanced Zero-shot Visual Question Answering Open
Zero-shot visual question answering (ZS-VQA), an emerged critical research area, intends to answer visual questions without providing training samples. Existing research in ZS-VQA has proposed to leverage knowledge graphs or large language…
View article: Redox-sensitive epigenetic activation of SUV39H1 contributes to liver ischemia-reperfusion injury
Redox-sensitive epigenetic activation of SUV39H1 contributes to liver ischemia-reperfusion injury Open
Liver ischemia-reperfusion (I/R) injury is a clinically relevant pathophysiological process that determines the effectiveness of life-saving liver transplantation, to which aberrant ROS accumulation plays a key role. In the present study w…
View article: Development of a Predictive Nomogram Model for Early Deep Vein Thrombosis in Postoperative Spontaneous Intracerebral Hemorrhage Patients
Development of a Predictive Nomogram Model for Early Deep Vein Thrombosis in Postoperative Spontaneous Intracerebral Hemorrhage Patients Open
The Caprini score and total surgical bleeding volume are meaningful self-reliant risk variables contributing to DVT occurrence in postoperative participants with SICH. We have created a straightforward and efficient model to predict early …
View article: Construction and validation of a risk prediction model for early hungry bone syndrome in maintenance hemodialysis patients post-parathyroidectomy.
Construction and validation of a risk prediction model for early hungry bone syndrome in maintenance hemodialysis patients post-parathyroidectomy. Open
Preoperative bone involvement, serum calcium, iPTH, ALP, and serum calcium on the first postoperative day are influencing factors for HBS in MHD patients with SHPT post-PTX. The constructed risk prediction model based on these factors is r…
View article: Sharp needle reconstructs peripheral outflow for patients with malfunctional arteriovenous fistula
Sharp needle reconstructs peripheral outflow for patients with malfunctional arteriovenous fistula Open
Sharp needle technology merged with PTA presents an effective and secure minimally invasive method for reconstructing the outflow tract, offering a new solution for recanalizing high-pressure or occluded fistulas.
View article: The insulin‐like growth factor binding protein–microfibrillar associated protein–sterol regulatory element binding protein axis regulates fibroblast–myofibroblast transition and cardiac fibrosis
The insulin‐like growth factor binding protein–microfibrillar associated protein–sterol regulatory element binding protein axis regulates fibroblast–myofibroblast transition and cardiac fibrosis Open
Background and Purpose Excessive fibrogenesis is associated with adverse cardiac remodelling and heart failure. The myofibroblast, primarily derived from resident fibroblast, is the effector cell type in cardiac fibrosis. Megakaryocytic le…
View article: TRIB1 regulates liver regeneration by antagonizing the NRF2-mediated antioxidant response
TRIB1 regulates liver regeneration by antagonizing the NRF2-mediated antioxidant response Open
Robust regenerative response post liver injuries facilitates the architectural and functional recovery of the liver. Intrahepatic redox homeostasis plays a key role in liver regeneration. In the present study, we investigated the contribut…
View article: An MRTF-A–ZEB1–IRF9 axis contributes to fibroblast–myofibroblast transition and renal fibrosis
An MRTF-A–ZEB1–IRF9 axis contributes to fibroblast–myofibroblast transition and renal fibrosis Open
Myofibroblasts, characterized by the expression of the matricellular protein periostin ( Postn ), mediate the profibrogenic response during tissue repair and remodeling. Previous studies have demonstrated that systemic deficiency in myocar…
View article: Zinc finger transcription factor Egf1 promotes non-alcoholic fatty liver disease
Zinc finger transcription factor Egf1 promotes non-alcoholic fatty liver disease Open
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) contributes to the global epidemic of metabolic syndrome and is considered a prelude to end-stage liver diseases such as cirrhosis and hepatocellular carcinoma. During NAFLD path…
View article: Targetable <scp>Brg1‐CXCL14</scp> axis contributes to alcoholic liver injury by driving neutrophil trafficking
Targetable <span>Brg1‐CXCL14</span> axis contributes to alcoholic liver injury by driving neutrophil trafficking Open
Alcoholic liver disease (ALD) accounts for a large fraction of patients with cirrhosis and hepatocellular carcinoma. In the present study we investigated the involvement of Brahma‐related gene 1 (Brg1) in ALD pathogenesis and implication i…
View article: Evaluation of indocyanine green combined with methylene blue staining in sentinel lymph node biopsy of breast cancer
Evaluation of indocyanine green combined with methylene blue staining in sentinel lymph node biopsy of breast cancer Open
ICG combined with methylene blue staining is a promising and effective tracing strategy in the SLNB of breast cancer with high detection and accuracy rates.
View article: GNAS mutations suppress the cell invasion through regulating EMT by activating the MEG3/Wnt/β-catenin pathway in growth hormone-secreting pituitary adenoma
GNAS mutations suppress the cell invasion through regulating EMT by activating the MEG3/Wnt/β-catenin pathway in growth hormone-secreting pituitary adenoma Open
Background: Approximately 30–40% of growth hormone-secreting pituitary adenoma (GHPA) harbor somatic mutations in the GNAS (α subunit of the stimulatory G protein) gene. However, the latent functional role of the mutations and relative mol…
View article: The combined application of antibiotic-loaded bone cement and vacuum sealing drainage for sternal reconstruction in the treatment of deep sternal wound infection
The combined application of antibiotic-loaded bone cement and vacuum sealing drainage for sternal reconstruction in the treatment of deep sternal wound infection Open
Background: Deep sternal wound infection (DSWI) is a rare but serious complication after median sternotomy, and treatment success depends mainly on surgical experience. Traditional treatment methods for DSWI include complete debridement, v…
View article: Down-regulation of miR-19b-3p enhances IGF-1 expression to induce osteoblast differentiation and improve osteoporosis
Down-regulation of miR-19b-3p enhances IGF-1 expression to induce osteoblast differentiation and improve osteoporosis Open
This research was conducted in order to investigate the role of miR-19b-3p in the development of osteoporosis (OP) in rats and the associated mechanisms. This study measured the expression levels of miR-19b-3p and IGF-1 in clinical OP pati…
View article: Knowledge-Enhanced Hierarchical Graph Transformer Network for Multi-Behavior Recommendation
Knowledge-Enhanced Hierarchical Graph Transformer Network for Multi-Behavior Recommendation Open
Accurate user and item embedding learning is crucial for modern recommender systems. However, most existing recommendation techniques have thus far focused on modeling users' preferences over singular type of user-item interactions. Many p…
View article: A GSK3-SRF Axis Mediates Angiotensin II Induced Endothelin Transcription in Vascular Endothelial Cells
A GSK3-SRF Axis Mediates Angiotensin II Induced Endothelin Transcription in Vascular Endothelial Cells Open
Endothelin, encoded by ET1 , is a vasoactive substance primarily synthesized in vascular endothelial cells (VECs). Elevation of endothelin levels, due to transcriptional hyperactivation, has been observed in a host of cardiovascular diseas…
View article: Redox-sensitive activation of CCL7 by BRG1 in hepatocytes during liver injury
Redox-sensitive activation of CCL7 by BRG1 in hepatocytes during liver injury Open
Liver injuries induced by various stimuli share in common an acute inflammatory response, in which circulating macrophages home to the liver parenchyma to participate in the regulation of repair, regeneration, and fibrosis. In the present …
View article: Corrigendum: An MRTF-A–Sp1–PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy
Corrigendum: An MRTF-A–Sp1–PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy Open
[This corrects the article DOI: 10.3389/fcell.2020.00839.].
View article: Activation of TC10-Like Transcription by Lysine Demethylase KDM4B in Colorectal Cancer Cells
Activation of TC10-Like Transcription by Lysine Demethylase KDM4B in Colorectal Cancer Cells Open
Malignant colorectal cancers (CRCs) are characterized by enhanced migration and invasion thus acquiring the ability to metastasize. We have previously shown that the small GTPase TC10-like (TCL) contributes to aggressive migration and inva…
View article: The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells
The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells Open
The small GTPase RHOJ is a key regulator of breast cancer metastasis by promoting cell migration and invasion. The prometastatic stimulus TGF-β activates RHOJ transcription via megakaryocytic leukemia 1 (MKL1). The underlying epigenetic me…
View article: Myeloid MKL1 Disseminates Cues to Promote Cardiac Hypertrophy in Mice
Myeloid MKL1 Disseminates Cues to Promote Cardiac Hypertrophy in Mice Open
Cardiac hypertrophy is a key pathophysiological process in the heart in response to stress cues. Although taking place in cardiomyocytes, the hypertrophic response is influenced by other cell types, both within the heart and derived from c…
View article: MiR-129-5p Suppresses Cell Proliferation of Human Osteosarcoma Cancer by Down-Regulating LncRNA Lnc712
MiR-129-5p Suppresses Cell Proliferation of Human Osteosarcoma Cancer by Down-Regulating LncRNA Lnc712 Open
MiR-129-5p may suppress cell proliferation of OS by down-regulating Lnc712.
View article: The Chromatin Remodeling Protein BRG1 Regulates SREBP Maturation by Activating SCAP Transcription in Hepatocytes
The Chromatin Remodeling Protein BRG1 Regulates SREBP Maturation by Activating SCAP Transcription in Hepatocytes Open
Sterol response element binding protein (SREBP) is a master regulator of cellular lipogenesis. One key step in the regulation of SREBP activity is its sequential cleavage and trans- location by several different proteinases including SREBP…
View article: Corrigendum: Transcriptional Activation of Matricellular Protein Spondin2 (SPON2) by BRG1 in Vascular Endothelial Cells Promotes Macrophage Chemotaxis
Corrigendum: Transcriptional Activation of Matricellular Protein Spondin2 (SPON2) by BRG1 in Vascular Endothelial Cells Promotes Macrophage Chemotaxis Open
[This corrects the article DOI: 10.3389/fcell.2020.00794.].