Lea Ann Chen
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View article: Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database Open
Incomplete penetrance, or absence of disease phenotype in an individual with a disease-associated variant, is a major challenge in variant interpretation. Studying individuals with apparent incomplete penetrance can shed light on underlyin…
View article: Assessment of PredictSURE IBD Assay in a Multinational Cohort of Patients With Inflammatory Bowel Disease
Assessment of PredictSURE IBD Assay in a Multinational Cohort of Patients With Inflammatory Bowel Disease Open
Background and Aims PredictSURE IBD is a prognostic blood test that classifies newly diagnosed, treatment‐naïve Inflammatory Bowel Disease (IBD) patients into ‘IBDhi’ (high‐risk) or ‘IBDlo’ (low‐risk) groups (risk of future aggressive dise…
View article: Fecal Microbial Community Profiling Allows Discrimination of Phenotype and Treatment Response in Pediatric Crohn’s Disease and Ulcerative Colitis—An International Meta-Analysis
Fecal Microbial Community Profiling Allows Discrimination of Phenotype and Treatment Response in Pediatric Crohn’s Disease and Ulcerative Colitis—An International Meta-Analysis Open
Background and aims The pathophysiology of pediatric inflammatory bowel disease (PIBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), is not entirely understood. Dysregulation of the intestinal microbiome is recognized as …
View article: Preferred Reporting Items for Microbiotherapy (PRIM) Guidelines Across Medical Disciplines: An International Delphi Consensus
Preferred Reporting Items for Microbiotherapy (PRIM) Guidelines Across Medical Disciplines: An International Delphi Consensus Open
Microbiotherapy has opened new avenues for managing dysbiosis‐related diseases. However, many studies did not cover all the necessary reporting items for microbiotherapy making the interpretation of results, safety assessment, technology e…
View article: Challenges in IBD Research 2024: Precision Medicine
Challenges in IBD Research 2024: Precision Medicine Open
Precision medicine is part of 5 focus areas of the Challenges in IBD Research 2024 research document, which also includes preclinical human IBD mechanisms, environmental triggers, novel technologies, and pragmatic clinical research. Buildi…
View article: The Role of the Gut Microbiome in Health and Disease in the Elderly
The Role of the Gut Microbiome in Health and Disease in the Elderly Open
Purpose of Review Growing evidence supports the contribution of age in the composition and function of the gut microbiome, with specific findings associated with health in old age and longevity. Recent Findings Current studies have associa…
View article: A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules
A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules Open
Changes in the gut microbiome have been associated with several human diseases, but the molecular and functional details underlying these associations remain largely unknown. Here, we performed a multi-cohort analysis of small molecule bio…
View article: UNAFFECTED RELATIVES WITH HIGH IBD POLYGENIC RISK SCORES FROM MULTIPLEX CROHN’S DISEASE FAMILIES CARRY MICROBIOMES THAT PROTECT IL-10 DEFICIENT MICE AGAINST INTESTINAL INFLAMMATION
UNAFFECTED RELATIVES WITH HIGH IBD POLYGENIC RISK SCORES FROM MULTIPLEX CROHN’S DISEASE FAMILIES CARRY MICROBIOMES THAT PROTECT IL-10 DEFICIENT MICE AGAINST INTESTINAL INFLAMMATION Open
Genetic and environmental influences contribute to Crohn’s disease (CD) development. However, the relationship between these two factors is unclear, limiting insights into CD pathophysiology, as well as interventions to prevent disease. To…
View article: Differential Manifestations of Inflammatory Bowel Disease Based on Race and Immigration Status
Differential Manifestations of Inflammatory Bowel Disease Based on Race and Immigration Status Open
IBD phenotype varies by race, although foreign-born patients of all races show evidence of later-onset and milder disease. These findings may aid in disease prognostication and clinical management and, furthermore, may provide insight into…
View article: Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares
Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares Open
View article: Longitudinal Bile Acid Composition Changes Following Faecal Microbiota Transplantation for <i>Clostridioides difficile</i> Infection in Children With and Without Underlying Inflammatory Bowel Disease
Longitudinal Bile Acid Composition Changes Following Faecal Microbiota Transplantation for <i>Clostridioides difficile</i> Infection in Children With and Without Underlying Inflammatory Bowel Disease Open
Background and Aims Faecal microbiota transplant [FMT] is effective in treating recurrent Clostridioides difficile infection [CDI] and restores gut microbiota composition. This is unlikely to account for its entire mechanism of efficacy, a…
View article: THE PRECIOUS STUDY: A PROSPECTIVE, OBSERVATIONAL STUDY OF CD8+ BIOMARKER BASED PROGNOSTIC TEST IN NORTH AMERICAN IBD PATIENTS
THE PRECIOUS STUDY: A PROSPECTIVE, OBSERVATIONAL STUDY OF CD8+ BIOMARKER BASED PROGNOSTIC TEST IN NORTH AMERICAN IBD PATIENTS Open
BACKGROUND The clinical course of IBD varies considerably among patients1. One barrier to personalized medicine in IBD is the lack of a reliable prognostic assay that can be used at diagnosis to guide effective therapy for each patient, to…
View article: WHOLE EXOME SEQUENCING OF A MULTIPLEX CROHN’S DISEASE FAMILY IDENTIFIES RARE ALTERATIONS IN PYGB AND<i>XRN2</i> AS POTENTIALLY HIGH IMPACT RISK VARIANTS OF DISEASE
WHOLE EXOME SEQUENCING OF A MULTIPLEX CROHN’S DISEASE FAMILY IDENTIFIES RARE ALTERATIONS IN PYGB AND<i>XRN2</i> AS POTENTIALLY HIGH IMPACT RISK VARIANTS OF DISEASE Open
BACKGROUND The study of multiplex Crohn’s disease (CD) families has played a critical role in our understanding of the disease, including the identification of the first recognized CD risk variants in NOD2, which remain among the highest i…
View article: Antibiotics in the pathogenesis of diabetes and inflammatory diseases of the gastrointestinal tract
Antibiotics in the pathogenesis of diabetes and inflammatory diseases of the gastrointestinal tract Open
View article: Long-Term Efficacy and Safety of Fecal Microbiota Transplantation for C. difficile Infections Across Academic and Private Clinical Settings
Long-Term Efficacy and Safety of Fecal Microbiota Transplantation for C. difficile Infections Across Academic and Private Clinical Settings Open
Purpose: Fecal microbiota transplant (FMT) is increasingly performed for Clostridioides difficile infection (CDI), although long-term efficacy and safety data are limited and are focused on results from academic medical centers rather than…
View article: Lupus disease flares are concordant with immune responses to blooms of lipoglycan-expressing <i>Ruminococcus blautia gnavus</i> strains arising from unstable gut microbiota communities
Lupus disease flares are concordant with immune responses to blooms of lipoglycan-expressing <i>Ruminococcus blautia gnavus</i> strains arising from unstable gut microbiota communities Open
Whereas genetic susceptibility for Systemic Lupus Erythematosus has been well explored, the precipitants for clinical disease flares remain a mystery. To investigate for dynamic-relationships between gut-microbial communities and Lupus dis…
View article: Effectiveness and safety of SARS‐CoV‐2 vaccine in Inflammatory Bowel Disease patients: a systematic review, meta‐analysis and meta‐regression
Effectiveness and safety of SARS‐CoV‐2 vaccine in Inflammatory Bowel Disease patients: a systematic review, meta‐analysis and meta‐regression Open
Introduction There are concerns regarding the effectiveness and safety of SARS‐CoV‐2 vaccine in inflammatory Bowel Disease (IBD) patients. This systematic review and meta‐analysis comprehensively summarises the available literature regardi…
View article: Gastrointestinal Manifestations of Coronavirus Disease 2019 Across the United States: A Multicenter Cohort Study
Gastrointestinal Manifestations of Coronavirus Disease 2019 Across the United States: A Multicenter Cohort Study Open
View article: Fr004 GASTROINTESTINAL MANIFESTATIONS OF COVID-19 IN ICU AND NON-ICU PATIENTS: A MULTI-CENTER COHORT STUDY
Fr004 GASTROINTESTINAL MANIFESTATIONS OF COVID-19 IN ICU AND NON-ICU PATIENTS: A MULTI-CENTER COHORT STUDY Open
View article: Fr007 GASTROINTESTINAL MANIFESTATIONS OF COVID-19 ACROSS THE UNITED STATES: A MULTI-CENTER COHORT STUDY
Fr007 GASTROINTESTINAL MANIFESTATIONS OF COVID-19 ACROSS THE UNITED STATES: A MULTI-CENTER COHORT STUDY Open
View article: Fecal microbiota transplantation: Uses, questions, and ethics
Fecal microbiota transplantation: Uses, questions, and ethics Open
View article: Correction to: Characterization of Creatine Kinase Levels in Tofacitinib‑Treated Patients with Ulcerative Colitis: Results from Clinical Trials
Correction to: Characterization of Creatine Kinase Levels in Tofacitinib‑Treated Patients with Ulcerative Colitis: Results from Clinical Trials Open
The article "Characterization of Creatine Kinase Levels in Tofacitinib–Treated Patients with Ulcerative Colitis: Results from Clinical Trials", written by Remo Panaccione, John D. Isaacs, Lea Ann Chen, Wenjin Wang, Amy Marren, Kenneth Kwok…
View article: Frequency and burden of gastrointestinal symptoms in familial dysautonomia
Frequency and burden of gastrointestinal symptoms in familial dysautonomia Open
View article: Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry
Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry Open
View article: Characterization of Creatine Kinase Levels in Tofacitinib-Treated Patients with Ulcerative Colitis: Results from Clinical Trials
Characterization of Creatine Kinase Levels in Tofacitinib-Treated Patients with Ulcerative Colitis: Results from Clinical Trials Open
View article: Intestinal Microbiota Transplantation for Patients With Inflammatory Bowel Disease Prevents Recurrence of <i>C. difficile</i> Infections but Not Recurrence of Gastrointestinal Symptoms
Intestinal Microbiota Transplantation for Patients With Inflammatory Bowel Disease Prevents Recurrence of <i>C. difficile</i> Infections but Not Recurrence of Gastrointestinal Symptoms Open
Intestinal microbiota transplantation (IMT) is an effective therapy for recurrent Clostridioides difficile infections in patients with inflammatory bowel disease (IBD). However, further research is needed to understand the safety of this p…
View article: Bariatric surgery is associated with increased risk of new‐onset inflammatory bowel disease: case series and national database study
Bariatric surgery is associated with increased risk of new‐onset inflammatory bowel disease: case series and national database study Open
Summary Background Case series suggest a possible association between bariatric surgery and incident IBD. Aim The aim of this study was to evaluate the association between bariatric surgery and new‐onset IBD . Methods We first conducted a …
View article: Burden of Ulcerative Colitis on Functioning and Well-being: A Systematic Literature Review of the SF-36® Health Survey
Burden of Ulcerative Colitis on Functioning and Well-being: A Systematic Literature Review of the SF-36® Health Survey Open
Patients with active UC experience a clinically meaningful burden of disease across most aspects of quality of life. Patients with inactive UC exhibit negligible disease burden and are comparable to the general population on most quality-o…
View article: Integrated Analysis of Biopsies from Inflammatory Bowel Disease Patients Identifies SAA1 as a Link Between Mucosal Microbes with TH17 and TH22 Cells
Integrated Analysis of Biopsies from Inflammatory Bowel Disease Patients Identifies SAA1 as a Link Between Mucosal Microbes with TH17 and TH22 Cells Open
This study identifies expression of SAA1 as an important link between mucosal T cells, microbial communities, and their tissue environment in patients with IBD. A combination of T cell effector function data, gene expression and microbial …
View article: Physicians Must Discuss Potential Long-Term Risks of Fecal Microbiota Transplantation to Ensure Informed Consent
Physicians Must Discuss Potential Long-Term Risks of Fecal Microbiota Transplantation to Ensure Informed Consent Open
Fecal microbiota transplantation (FMT) for patients with
\nmultiply recurrent Clostridium difficile (C. difficile) infections
\ndespite standard medical treatment is considered both
\neffective, with approximately 90% cured (Aroniadis et a…