Lea L. Friker
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View article: RADT-14. REIRRADIATION OF RECURRENT GLIOBLASTOMA: RESULTS FROM A SINGLE-CENTER RETROSPECTIVE COHORT STUDY
RADT-14. REIRRADIATION OF RECURRENT GLIOBLASTOMA: RESULTS FROM A SINGLE-CENTER RETROSPECTIVE COHORT STUDY Open
PURPOSE The management of recurrent glioblastoma (rGBM) remains a clinical challenge, with only limited therapeutic options available to date. Reirradiation may offer a progression-free survival (PFS) benefit in selected cases, but data ar…
View article: NCOG-40. Surgery for temporal lower-grade glioma: does extent of resection impair neurocognitive outcome?
NCOG-40. Surgery for temporal lower-grade glioma: does extent of resection impair neurocognitive outcome? Open
INTRODUCTION With regard to superior long-term disease control, anterior temporal lobectomies (ATL) as a supra-total resection regime have gained growing attention in surgery for temporal lobe tumors. However, aggressive temporal tumor res…
View article: PATH-57. The GLIOSCREEN trial: Feasibility, genomic landscape, and clinical impact of prospective comprehensive molecular profiling in newly diagnosed glioma
PATH-57. The GLIOSCREEN trial: Feasibility, genomic landscape, and clinical impact of prospective comprehensive molecular profiling in newly diagnosed glioma Open
BACKGROUND Advances in molecular profiling have significantly improved the diagnostic precision of diffuse gliomas. However, translating genomic data into individualized clinical strategies remains challenging due to the heterogeneity of g…
View article: P03.02.A AMIDE PROTON TRANSFER-WEIGHTED (APTW) MRI IN CLINICAL ROUTINE FOR RESPONSE ASSESSMENT OF GLIOBLASTOMA
P03.02.A AMIDE PROTON TRANSFER-WEIGHTED (APTW) MRI IN CLINICAL ROUTINE FOR RESPONSE ASSESSMENT OF GLIOBLASTOMA Open
BACKGROUND Response assessment in Glioblastoma (GBM) poses significant challenges, particularly in the presence of therapy-related MRI changes, which can occur at any time point during and after treatment. A reliable diagnostic method for …
View article: P09.08.A REIRRADIATION OF RECURRENT GLIOBLASTOMA: RESULTS FROM A SINGLE-CENTER RETROSPECTIVE COHORT STUDY
P09.08.A REIRRADIATION OF RECURRENT GLIOBLASTOMA: RESULTS FROM A SINGLE-CENTER RETROSPECTIVE COHORT STUDY Open
BACKGROUND The management of recurrent glioblastoma (rGBM) remains a clinical challenge, with only limited therapeutic options available to date. Reirradiation may offer a progression-free survival (PFS) benefit in selected cases, but data…
View article: P01.24.B CORE2EDGE: A HUMAN GLIOBLASTOMA ORGANOID AND BRAIN SLICE CO-CULTURE MODEL CAPTURING TUMOR INFILTRATION AND TRANSCRIPTIONAL HETEROGENEITY FROM CORE TO SINGLE-CELL DISPERSION
P01.24.B CORE2EDGE: A HUMAN GLIOBLASTOMA ORGANOID AND BRAIN SLICE CO-CULTURE MODEL CAPTURING TUMOR INFILTRATION AND TRANSCRIPTIONAL HETEROGENEITY FROM CORE TO SINGLE-CELL DISPERSION Open
BACKGROUND Glioblastomas function as intricate cellular networks that extend into the surrounding brain tissue enabling long distance communication. This malignant connectivity spans from the tumor core to remote infiltration zones, suppor…
View article: Flow cytometry protocol for cell death analysis in glioblastoma organoids: A technical note
Flow cytometry protocol for cell death analysis in glioblastoma organoids: A technical note Open
Tumor organoid models have emerged as a promising tool in cancer research. By preserving intra- and intertumoral heterogeneity and structural integrity they provide a physiologically relevant platform for drug-response studies. However, va…
View article: Intraoperative radiotherapy for resectable brain metastases: a systematic review and meta-analysis
Intraoperative radiotherapy for resectable brain metastases: a systematic review and meta-analysis Open
IORT for patients with BMs has a favorable toxicity profile and yields excellent local control. A potential advantage is the rapid completion of interdisciplinary BM treatment, allowing a swift transition to subsequent cancer treatments. A…
View article: Reirradiation of recurrent glioblastoma: Results from a single-center retrospective cohort study
Reirradiation of recurrent glioblastoma: Results from a single-center retrospective cohort study Open
View article: Temozolomide-based radio-chemotherapy for newly diagnosed pediatric high-grade gliomas (HIT-HGG-2007): A prospective, multicenter, single-arm, phase II trial
Temozolomide-based radio-chemotherapy for newly diagnosed pediatric high-grade gliomas (HIT-HGG-2007): A prospective, multicenter, single-arm, phase II trial Open
Background: The HIT-HGG-2007 trial investigated temozolomide (TMZ) radio-chemotherapy for pediatric patients with high-grade gliomas (pHGG) to demonstrate therapeutic non-inferiority compared to previous intensive radio-chemotherapy regime…
View article: Pitfalls in the evaluation of CDKN2A copy number status in meningioma
Pitfalls in the evaluation of CDKN2A copy number status in meningioma Open
View article: Diffuse pediatric high-grade glioma of methylation-based RTK2A and RTK2B subclasses present distinct radiological and histomolecular features including Gliomatosis cerebri phenotype
Diffuse pediatric high-grade glioma of methylation-based RTK2A and RTK2B subclasses present distinct radiological and histomolecular features including Gliomatosis cerebri phenotype Open
Diffuse pediatric-type high-grade gliomas (pedHGG), H3- and IDH-wildtype, encompass three main DNA-methylation-based subtypes: pedHGG-MYCN, pedHGG-RTK1A/B/C, and pedHGG-RTK2A/B. Since their first description in 2017 tumors of pedHGG-RTK2A/…
View article: Transient MRI changes and neurological deterioration in glioblastoma upon SARS-CoV-2 infection
Transient MRI changes and neurological deterioration in glioblastoma upon SARS-CoV-2 infection Open
Purpose Little is known about the effect of SARS-CoV-2 infection on glioblastoma (GBM) growth, metabolism, and prognosis. Immunological changes within GBM tissue are potentially symptomatic, underlining the urgent need for a better underst…
View article: LGG-32. MALIGNANT TRANSFORMATION OF PEDIATRIC LOW-GRADE GLIOMA TO SECONDARY HIGH-GRADE GLIOMA - REPORT FROM THE GERMAN BRAIN TUMOR STUDIES
LGG-32. MALIGNANT TRANSFORMATION OF PEDIATRIC LOW-GRADE GLIOMA TO SECONDARY HIGH-GRADE GLIOMA - REPORT FROM THE GERMAN BRAIN TUMOR STUDIES Open
BACKGROUND Malignant transformation (MT) of pediatric low-grade glioma (pLGG) to secondary high-grade glioma (sHGG) is a rare but momentous event. We explored its clinical, epidemiologic, and molecular characteristics and risk factors. MET…
View article: HGG-16. PEDIATRIC-TYPE DIFFUSE HIGH-GRADE GLIOMA OF METHYLATION-BASED RTK2A AND RTK2B SUBCLASSES PRESENT DISTINCT RADIOLOGICAL AND HISTOMOLECULAR FEATURES
HGG-16. PEDIATRIC-TYPE DIFFUSE HIGH-GRADE GLIOMA OF METHYLATION-BASED RTK2A AND RTK2B SUBCLASSES PRESENT DISTINCT RADIOLOGICAL AND HISTOMOLECULAR FEATURES Open
BACKGROUND Diffuse pediatric-type high-grade gliomas (pedHGG), H3-wildtype and IDH-wildtype, encompass three main methylome-based subclasses: pedHGG-MYCN, -RTK1A/B/C, and -RTK2A/B. Since their first description in 2017, tumors of pedHGG-RT…
View article: DIPG-57. INITIAL AND EARLY METASTATIC SPREAD IN DIPG AND DIFFUSE MIDLINE GLIOMA, H3 K27-ALTERED - REPORT FROM THE EUROPEAN SOCIETY FOR PEDIATRIC ONCOLOGY (SIOPE) AND INTERNATIONAL DIPG/DMG REGISTRIES
DIPG-57. INITIAL AND EARLY METASTATIC SPREAD IN DIPG AND DIFFUSE MIDLINE GLIOMA, H3 K27-ALTERED - REPORT FROM THE EUROPEAN SOCIETY FOR PEDIATRIC ONCOLOGY (SIOPE) AND INTERNATIONAL DIPG/DMG REGISTRIES Open
BACKGROUND We aimed to assess frequency, patterns and potential prognostic impact of initial and early dissemination in pediatric patients with diffuse intrinsic pontine glioma (DIPG) and diffuse midline glioma, H3K27-altered (DMG). METHOD…
View article: HGG-26. MLH1, MSH2, MSH6, AND PMS2 IMMUNOHISTOCHEMISTRY REPRESENTS A HIGHLY SENSITIVE SCREENING METHOD FOR MISMATCH REPAIR DEFICIENCY SYNDROMES IN PEDIATRIC HIGH-GRADE GLIOMA
HGG-26. MLH1, MSH2, MSH6, AND PMS2 IMMUNOHISTOCHEMISTRY REPRESENTS A HIGHLY SENSITIVE SCREENING METHOD FOR MISMATCH REPAIR DEFICIENCY SYNDROMES IN PEDIATRIC HIGH-GRADE GLIOMA Open
BACKGROUND Pediatric central nervous system (CNS) tumors can occur as first manifestations of cancer predisposition syndromes (CPS) resulting from pathogenic variants in DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2. Early det…
View article: Preclinical evidence for the use of <scp>anti‐Trop</scp>‐2 antibody‐drug conjugate Sacituzumab govitecan in cerebral metastasized castration‐resistant prostate cancer
Preclinical evidence for the use of <span>anti‐Trop</span>‐2 antibody‐drug conjugate Sacituzumab govitecan in cerebral metastasized castration‐resistant prostate cancer Open
Purpose Improved survival rates have been observed in castration‐resistant prostate cancer (CRPC) due to advancements in treatment options. However, individuals with brain metastases still have limited therapeutic options and an unfavorabl…
View article: L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy in newly-diagnosed glioblastoma: dose escalation of the phase I/II GLORIA trial
L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy in newly-diagnosed glioblastoma: dose escalation of the phase I/II GLORIA trial Open
View article: Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile
Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile Open
Background The term gliomatosis cerebri (GC), a radiology-defined highly infiltrating diffuse glioma, has been abandoned since molecular GC-associated features could not be established. Methods We conducted a multinational retrospective st…
View article: Dynamics of Microglia-Glioblastoma Crosstalk at the Far Infiltration Zone
Dynamics of Microglia-Glioblastoma Crosstalk at the Far Infiltration Zone Open
View article: Intraoperative or postoperative stereotactic radiotherapy for brain metastases: time to systemic treatment onset and other patient-relevant outcomes
Intraoperative or postoperative stereotactic radiotherapy for brain metastases: time to systemic treatment onset and other patient-relevant outcomes Open
View article: Outcome assessment of intraoperative radiotherapy for brain metastases: results of a prospective observational study with comparative matched-pair analysis
Outcome assessment of intraoperative radiotherapy for brain metastases: results of a prospective observational study with comparative matched-pair analysis Open
Purpose Intraoperative radiation therapy (IORT) is an emerging alternative to adjuvant stereotactic external beam radiation therapy (EBRT) following resection of brain metastases (BM). Advantages of IORT include an instant prevention of tu…
View article: Five-Fraction Stereotactic Radiotherapy for Brain Metastases—A Retrospective Analysis
Five-Fraction Stereotactic Radiotherapy for Brain Metastases—A Retrospective Analysis Open
Purpose: To determine the safety and outcome profile of five-fraction stereotactic radiotherapy (FSRT) for brain metastases (BM), either as a definitive or adjuvant treatment. Methods: We assessed clinical data of patients receiving five f…
View article: The Debatable Benefit of Gross-Total Resection of Brain Metastases in a Comprehensive Treatment Setting
The Debatable Benefit of Gross-Total Resection of Brain Metastases in a Comprehensive Treatment Setting Open
Background and Purpose: The value of gross-total surgical resection remains debatable in patients with brain metastases (BMs) as most patients succumb to systemic disease progression. In this study, we evaluated the impact of the extent of…