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View article: Gas Plasma-Induced Oxidative Transformation of Glucose
Gas Plasma-Induced Oxidative Transformation of Glucose Open
Background: Glucose, a central carbohydrate in higher organisms’ metabolism, can undergo extensive oxidative modification under conditions of excessive inflammation or elevated reactive oxygen and nitrogen species (RONS). Such modification…
View article: Scratching in Style: 3D Printers as Plotters for Automated and Complex Wound Healing Assays
Scratching in Style: 3D Printers as Plotters for Automated and Complex Wound Healing Assays Open
View article: Gas Plasma Combination Therapies—Promises from Preclinical Oncology Research
Gas Plasma Combination Therapies—Promises from Preclinical Oncology Research Open
The absent decline in cancer mortality rates is primarily due to moderate therapeutic efficacy and intrinsic or acquired tumor cell resistance toward treatments. Combining different oncology treatments increases therapy success and decreas…
View article: Gas plasma technology mediates deep tissue and anticancer events independently of hydrogen peroxide
Gas plasma technology mediates deep tissue and anticancer events independently of hydrogen peroxide Open
Reactive oxygen species (ROS) can be used as anticancer agents. Some technologies, such as medical gas plasmas, generate large amounts and varieties of these mainly short-lived, reactive molecules. However, it is unclear how far reactive s…
View article: Temporal analysis of a miniaturized plasma jet: a comprehensive study of the electrical and chemical characteristics
Temporal analysis of a miniaturized plasma jet: a comprehensive study of the electrical and chemical characteristics Open
Due to the promising results of medical applications of atmospheric pressure plasmas (APPs), the plasma medicine research field has been growing consistently along the last two decades. Among the possible configurations for producing APPs,…
View article: High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins
High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins Open
Cerebral cavernous malformations (CCMs) are clusters of thin-walled enlarged blood vessels in the central nervous system that are prone to recurrent hemorrhage and can occur in both sporadic and familial forms. The familial form results fr…
View article: Why Cold Gas Plasma Technology for Wound Healing?
Why Cold Gas Plasma Technology for Wound Healing? Open
View article: Medical gas plasma modifies Nrf2 signaling in diabetic wound healing
Medical gas plasma modifies Nrf2 signaling in diabetic wound healing Open
The present finding of accelerated wound healing by the Nrf2 activator underlines the high potential of medical gas plasma therapy in non-diabetic and diabetic wound healing.
View article: RAW264.7 Macrophages as a Polarization Model in the Context of Pancreatic Cancer and Chemokine Release
RAW264.7 Macrophages as a Polarization Model in the Context of Pancreatic Cancer and Chemokine Release Open
The TME is a critical niche for determining the fate of cancer therapy. Tumor cells often polarize nontumor cells, including immune cells, in the TME to favor cancer growth. In pancreatic cancer, macrophages are associated with poor therap…
View article: Viral inactivation of murine coronavirus via multiple gas plasma-derived reactive species
Viral inactivation of murine coronavirus via multiple gas plasma-derived reactive species Open
View article: Gas Plasma Technology and Immunogenic Cell Death: Implications for Chordoma Treatment
Gas Plasma Technology and Immunogenic Cell Death: Implications for Chordoma Treatment Open
Cancer is the second-leading cause of death in developed societies. Specifically, cancers of the spine and brain come with significant therapeutic challenges. Chordomas are semi-malignant tumors that develop from embryonic residuals at the…
View article: Biomimetic Hydrogels – Tools for Regenerative Medicine, Oncology, and Understanding Medical Gas Plasma Therapy
Biomimetic Hydrogels – Tools for Regenerative Medicine, Oncology, and Understanding Medical Gas Plasma Therapy Open
Biomimetic hydrogels enable biochemical, cell biology, and tissue‐like studies in the third dimension. Smart hydrogels are also frequently used in tissue engineering and as drug carriers for intra‐ or extracutaneous regenerative medicine. …
View article: Rationales of Cold Plasma Jet Therapy in Skin Cancer
Rationales of Cold Plasma Jet Therapy in Skin Cancer Open
Skin cancer affects millions of patients worldwide, and its incidence is increasing. Current therapies targeting skin tumour subtypes, such as basal cell carcinoma, cutaneous squamous cell carcinoma, melanoma and actinic keratosis, vary in…
View article: Lyophilized human platelet lysate: manufacturing, quality control, and application
Lyophilized human platelet lysate: manufacturing, quality control, and application Open
Background A significant number of platelet concentrates (PCs) is discarded daily in blood banks due to limited shelf life. Human platelet lysate (HPL), derived from expired PCs, has gained attention as an ethical and sustainable cell cult…
View article: Transcriptional Pathways Predisposing to Cancer Oxidative Stress Sensitivity and Resistance Are Shared Between Hydrogen Peroxide and Cold Gas Plasma but Not Hypochlorous Acid
Transcriptional Pathways Predisposing to Cancer Oxidative Stress Sensitivity and Resistance Are Shared Between Hydrogen Peroxide and Cold Gas Plasma but Not Hypochlorous Acid Open
Oxidative stress is universal to all cell types, including cancer. It is elicited by a surplus of reactive oxygen species (ROS) or a reduced cellular ability to defend against those. At low levels (oxidative eustress), this induces altered…
View article: Reactive Species Production and Colon Cancer Cytotoxicity of an Electrosurgical Cold Argon Plasma Device
Reactive Species Production and Colon Cancer Cytotoxicity of an Electrosurgical Cold Argon Plasma Device Open
In a narrow definition, plasma medicine is the application of body‐temperature cold plasma devices for medical purposes. If considering the more general application of plasma devices in medicine, independent of the operating temperature, e…
View article: Oxidation using medical gas plasma induces immunogenic cell death in primary cultures of high-grade glioma cells
Oxidation using medical gas plasma induces immunogenic cell death in primary cultures of high-grade glioma cells Open
View article: Immunophenotyping of Circulating and Intratumoral Myeloid and T Cells in Glioblastoma Patients
Immunophenotyping of Circulating and Intratumoral Myeloid and T Cells in Glioblastoma Patients Open
View article: Plasma‐Treated Liquids for Medicine: A Narrative Review on State and Perspectives
Plasma‐Treated Liquids for Medicine: A Narrative Review on State and Perspectives Open
Plasma‐treated liquids and their medical application have gained momentum in the fields of plasma science in recent years. Most research has been done in the field of cancer treatment. Another new and promising special field of CAP−liquid …
View article: High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins
High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins Open
Cerebral cavernous malformations (CCMs) are clusters of thin-walled enlarged blood vessels in the central nervous system that are prone to recurrent hemorrhage and can occur in both sporadic and familial forms. The familial form results fr…
View article: Markers of tumor-associated macrophages and microglia exhibit high intratumoral heterogeneity in human glioblastoma tissue
Markers of tumor-associated macrophages and microglia exhibit high intratumoral heterogeneity in human glioblastoma tissue Open
The study showed high intratumoral heterogeneity in GBM, emphasizing the need for a more detailed understanding of the tumor microenvironment. The described findings could be essential for future personalized treatment strategies and the i…
View article: Ultraviolet laser induced periodic surface structures positively influence osteogenic activity on titanium alloys
Ultraviolet laser induced periodic surface structures positively influence osteogenic activity on titanium alloys Open
Background/Objective Endoprostheses might fail due to complications such as implant loosening or periprosthetic infections. The surface topography of implant materials is known to influence osseointegration and attachment of pathogenic bac…
View article: Reactive oxygen species from non-thermal gas plasma (CAP): implication for targeting cancer stem cells
Reactive oxygen species from non-thermal gas plasma (CAP): implication for targeting cancer stem cells Open
Cancer remains a major global health challenge, with the persistence of cancer stem cells (CSCs) contributing to treatment resistance and relapse. Despite advancements in cancer therapy, targeting CSCs presents a significant hurdle. Non-th…
View article: Insulin oxidation and oxidative modifications alter glucose uptake, cell metabolism, and inflammatory secretion profiles
Insulin oxidation and oxidative modifications alter glucose uptake, cell metabolism, and inflammatory secretion profiles Open
Insulin participates in glucose homeostasis in the body and regulates glucose, protein, and lipid metabolism. Chronic hyperglycemia triggers oxidative stress and the generation of reactive oxygen species (ROS), leading to oxidized insulin …
View article: Hypoxia increases triacylglycerol levels and unsaturation in tomato roots
Hypoxia increases triacylglycerol levels and unsaturation in tomato roots Open
Background Plants are designed to endure stress, but increasingly extreme weather events are testing the limits. Events like flooding result in submergence of plant organs, triggering an energy crisis due to hypoxia and threaten plant grow…
View article: Comparative Analysis of Canonical Inflammasome Activation by Flow Cytometry, Imaging Flow Cytometry and High-Content Imaging
Comparative Analysis of Canonical Inflammasome Activation by Flow Cytometry, Imaging Flow Cytometry and High-Content Imaging Open
Inflammasome activation occurs in various diseases, including rare diseases that require multicenter studies for investigation. Flow cytometric analysis of ASC speck + cells in patient samples can be used to detect cell type-specific infla…
View article: Epilipidomics reveals lipid fatty acid and headgroup modification in gas plasma-oxidized biomembranes
Epilipidomics reveals lipid fatty acid and headgroup modification in gas plasma-oxidized biomembranes Open
View article: Targeting the Complexity of In Vitro Skin Models: A Review of Cutting-Edge Developments
Targeting the Complexity of In Vitro Skin Models: A Review of Cutting-Edge Developments Open
View article: YAP/TAZ, beta-catenin, and TGFb pathway activation in medical plasma-induced wound healing in diabetic mice
YAP/TAZ, beta-catenin, and TGFb pathway activation in medical plasma-induced wound healing in diabetic mice Open
Our study evaluated the cellular regulation of essential targets of the Hippo and related pathways such as YAP/TAZ, β-catenin, tumor growth factor β, and oxidative stress signaling after plasma treatment. The activation of genes, pathways,…
View article: A fast and reliable microplate reader assay to assess the antiviral efficacy of cold plasma devices
A fast and reliable microplate reader assay to assess the antiviral efficacy of cold plasma devices Open
Spurred by global COVID‐19, work in recent years has demonstrated that various devices based on technology generating cold plasma are capable of reducing the infectivity of virus particles. There is great potential in this approach, which …