Lea Seidel
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View article: Somatic STAT5BN642H mutations shape variable immune landscapes resulting in heterogenous immune diseases
Somatic STAT5BN642H mutations shape variable immune landscapes resulting in heterogenous immune diseases Open
Our findings illuminate how a single somatic variant in few stem cells can remodel hematopoiesis, generating variable immune mosaics and heterogeneous immune disease.
View article: Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues
Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues Open
Capillary electrophoresis mass spectrometry demonstrates that the inositol pyrophosphates 2-PP-InsP5 and 4- or 6-PP-InsP5 exist in different mammalian tissues in addition to canonical isomers.
View article: Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues
Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues Open
Technical challenges have to date prevented a complete profiling of the levels of myo-inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) in mammalian tissues. Here, we have deployed capillary electrophoresis mass spectrometry to ide…
View article: BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells
BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells Open
B cell activating factor (BAFF) provides B cells with essential survival signals. It binds to three receptors: BAFFR, TACI, and BCMA that are differentially expressed by B cell subsets. BAFFR is early expressed in circulating B cells and p…