Léa Siegwald
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View article: A young child formula with Limosilactobacillus reuteri and GOS modulates gut microbiome and enhances bone and muscle development: a randomized trial
A young child formula with Limosilactobacillus reuteri and GOS modulates gut microbiome and enhances bone and muscle development: a randomized trial Open
In this randomized, double-blind controlled trial, 182 Filipino children aged 2-3 years received either an experimental young child formula (EYCF) containing a combination of Limosilactobacillus reuteri DSM 17938 and galacto-oligosaccharid…
View article: Mechanistic insights into microbiome-dependent and personalized responses to dietary fibre in a randomized controlled trial
Mechanistic insights into microbiome-dependent and personalized responses to dietary fibre in a randomized controlled trial Open
Dietary fiber supplementation can reduce cardiometabolic risk, but its effective use is limited by incomplete understanding of fibre-microbiome interactions and highly individualized responses. We tested acacia gum (AG; fermentable fibre),…
View article: A YOUNG CHILD FORMULA SUPPLEMENTED WITH L. REUTERI AND GALACTO-OLIGOSACCHARIDES MODULATES THE COMPOSITION AND FUNCTION OF THE GUT MICROBIOME SUPPORTING BONE AND MUSCLE DEVELOPMENT IN TODDLERS
A YOUNG CHILD FORMULA SUPPLEMENTED WITH L. REUTERI AND GALACTO-OLIGOSACCHARIDES MODULATES THE COMPOSITION AND FUNCTION OF THE GUT MICROBIOME SUPPORTING BONE AND MUSCLE DEVELOPMENT IN TODDLERS Open
Importance Toddlerhood is a key window of opportunity for development of musculoskeletal system and microbiome. In this study we tested the efficacy of a synbiotic-based young child formula on bone and muscle strength and microbiome matura…
View article: Informed interpretation of metagenomic data by StrainPhlAn enables strain retention analyses of the upper airway microbiome
Informed interpretation of metagenomic data by StrainPhlAn enables strain retention analyses of the upper airway microbiome Open
Shotgun metagenomic sequencing has the potential to provide bacterial strain-level resolution which is of key importance to tackle a host of clinical questions. While bioinformatic tools that achieve strain-level resolution are available, …
View article: An Extensively Hydrolyzed Formula Supplemented with Two Human Milk Oligosaccharides Modifies the Fecal Microbiome and Metabolome in Infants with Cow’s Milk Protein Allergy
An Extensively Hydrolyzed Formula Supplemented with Two Human Milk Oligosaccharides Modifies the Fecal Microbiome and Metabolome in Infants with Cow’s Milk Protein Allergy Open
Cow’s milk protein allergy (CMPA) is a prevalent food allergy among infants and young children. We conducted a randomized, multicenter intervention study involving 194 non-breastfed infants with CMPA until 12 months of age (clinical trial …
View article: Application of Computational Data Modeling to a Large-Scale Population Cohort Assists the Discovery of Inositol as a Strain-Specific Substrate for Faecalibacterium prausnitzii
Application of Computational Data Modeling to a Large-Scale Population Cohort Assists the Discovery of Inositol as a Strain-Specific Substrate for Faecalibacterium prausnitzii Open
Faecalibacterium prausnitzii (F. prausnitzii) is a bacterial taxon in the human gut with anti-inflammatory properties, and this may contribute to the beneficial effects of healthy eating habits. However, little is known about the nutrients…
View article: Informed interpretation of metagenomic data by StrainPhlAn enables strain retention analyses of the upper airway microbiome
Informed interpretation of metagenomic data by StrainPhlAn enables strain retention analyses of the upper airway microbiome Open
Background: Shotgun metagenomic sequencing has the potential to provide bacterial strain-level resolution which is of key importance to tackle a host of clinical questions. While bioinformatics tools that achieve strain-level resolution ar…
View article: Application of computational data modeling to a large-scale population cohort assists the discovery of specific nutrients that influence beneficial human gut bacteria<i>Faecalibacterium prausnitzii</i>
Application of computational data modeling to a large-scale population cohort assists the discovery of specific nutrients that influence beneficial human gut bacteria<i>Faecalibacterium prausnitzii</i> Open
Faecalibacterium prausnitzii ( F. prausnitzii ) is a bacterial taxon of the human gut with anti-inflammatory properties and negative associations with chronic inflammatory conditions. F. prausnitzii may be one of key species contributing t…
View article: Erratum: Rémy et al. Modelling the Impact of Chronic Cigarette Smoke Exposure in Obese Mice: Metabolic, Pulmonary, Intestinal, and Cardiac Issues. Nutrients 2020, 12, 827
Erratum: Rémy et al. Modelling the Impact of Chronic Cigarette Smoke Exposure in Obese Mice: Metabolic, Pulmonary, Intestinal, and Cardiac Issues. Nutrients 2020, 12, 827 Open
The authors have requested that the following changes be made to their paper [...]
View article: Modelling the Impact of Chronic Cigarette Smoke Exposure in Obese Mice: Metabolic, Pulmonary, Intestinal, and Cardiac Issues
Modelling the Impact of Chronic Cigarette Smoke Exposure in Obese Mice: Metabolic, Pulmonary, Intestinal, and Cardiac Issues Open
Unhealthy lifestyle choices, such as bad eating behaviors and cigarette smoking, have major detrimental impacts on health. However, the inter-relations between obesity and smoking are still not fully understood. We thus developed an experi…
View article: Linking Human Milk Oligosaccharides, Infant Fecal Community Types, and Later Risk To Require Antibiotics
Linking Human Milk Oligosaccharides, Infant Fecal Community Types, and Later Risk To Require Antibiotics Open
Human milk is the sole and recommended nutrition for the newborn infant and contains one of the largest constituents of diverse oligosaccharides, dubbed human milk oligosaccharides (HMOs). Preclinical and clinical association studies indic…
View article: The Impact of Bioinformatics Pipelines on Microbiota Studies: Does the Analytical “Microscope” Affect the Biological Interpretation?
The Impact of Bioinformatics Pipelines on Microbiota Studies: Does the Analytical “Microscope” Affect the Biological Interpretation? Open
Targeted metagenomics is the solution of choice to reveal differential microbial profiles (defined by richness, diversity and composition) as part of case-control studies. It is well documented that each data processing step may have the p…
View article: Solutions to improve targeted metagenomics studies
Solutions to improve targeted metagenomics studies Open
La métagénomique ciblée, étude de la composition et de la diversité des communautés microbiennes présentes dans différents échantillon biologiques sur la base d'un marqueur génomique, a connu un véritable essor lors de cette dernière décen…
View article: Assessment of Common and Emerging Bioinformatics Pipelines for Targeted Metagenomics
Assessment of Common and Emerging Bioinformatics Pipelines for Targeted Metagenomics Open
Targeted metagenomics, also known as metagenetics, is a high-throughput sequencing application focusing on a nucleotide target in a microbiome to describe its taxonomic content. A wide range of bioinformatics pipelines are available to ana…