Lea Zillich
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View article: Dynamic Epigenetic Changes During Antidepressant Pharmacotherapy in Major Depressive Disorder
Dynamic Epigenetic Changes During Antidepressant Pharmacotherapy in Major Depressive Disorder Open
Background Although antidepressants remain the main pharmacological treatment for major depressive disorder (MDD), therapeutic response is highly variable, highlighting the need for reliable markers that predict and mechanistically explain…
View article: Cell type-specific methylome-wide association studies of childhood ADHD symptoms
Cell type-specific methylome-wide association studies of childhood ADHD symptoms Open
Studying DNA methylation (DNAm) can provide insights into gene-regulatory mechanisms underlying attention-deficit/hyperactivity disorder (ADHD). While most DNAm studies were performed in bulk tissue, this study used statistical deconvoluti…
View article: Longitudinal characterization of inflammatory plasma protein signatures in ECT response
Longitudinal characterization of inflammatory plasma protein signatures in ECT response Open
Symptom improvement during ECT is associated with reductions in specific inflammatory and neuroimmune markers, suggesting a potential link to the therapeutic mechanisms. These findings provide preliminary indications of immune involvement …
View article: Capturing disease severity in LIS1-lissencephaly reveals proteostasis dysregulation in patient-derived forebrain organoids
Capturing disease severity in LIS1-lissencephaly reveals proteostasis dysregulation in patient-derived forebrain organoids Open
View article: DNA Methylation Signatures of Alcohol Use Disorder – A large-scale Meta-Analysis in the Psychiatric Genomics Consortium
DNA Methylation Signatures of Alcohol Use Disorder – A large-scale Meta-Analysis in the Psychiatric Genomics Consortium Open
Despite extensive research on DNA methylation (DNAm) signatures associated with alcohol use disorder (AUD), findings are often inconsistent and not replicated. We conducted a large-scale meta-analysis of epigenome-wide association studies …
View article: Blood-based DNA methylation profiles in major depressive disorder, bipolar disorder, and schizophrenia spectrum disorders
Blood-based DNA methylation profiles in major depressive disorder, bipolar disorder, and schizophrenia spectrum disorders Open
View article: A systematic review of methylome-wide associations with anxiety disorders
A systematic review of methylome-wide associations with anxiety disorders Open
Anxiety disorders (ANX) are a prevalent public health burden that significantly impair daily functioning and decrease quality of life. A growing body of research suggests that DNA methylation (DNAm), an epigenetic modification that can imp…
View article: Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood
Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood Open
Maternal sustained smoking has the largest impact on newborn DNA methylation, suggesting a strong influence of the intrauterine environment. We observed minimal impacts for less studied exposures including SHS, maternal former smoking and …
View article: Epigenetic markers of disease risk and psychotherapy response in anxiety disorders – a longitudinal analysis of the DNA methylome
Epigenetic markers of disease risk and psychotherapy response in anxiety disorders – a longitudinal analysis of the DNA methylome Open
Epigenetic mechanisms such as DNA methylation are hypothesized to play a pivotal role in the pathogenesis of anxiety disorders and to predict as well as relate to treatment response. An epigenome-wide association study (EWAS) (Illumina Met…
View article: Development of a fully human glioblastoma-in-brain-spheroid model for accelerated translational research
Development of a fully human glioblastoma-in-brain-spheroid model for accelerated translational research Open
This physiologically relevant human model system provides new opportunities for studying GBM biology and tumor-neuron interactions in a controlled environment. By bridging the gap between simplified in vitro systems and complex in vivo mod…
View article: Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium
Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium Open
Children born via cesarean delivery have a higher risk of metabolic, immunological, and neurodevelopmental disorders compared to those born via vaginal delivery, although mechanisms remain unclear. We conducted a meta-analysis of epigenome…
View article: Genome-wide association study of borderline personality disorder identifies 11 loci and highlights shared risk with mental and somatic disorders
Genome-wide association study of borderline personality disorder identifies 11 loci and highlights shared risk with mental and somatic disorders Open
We conducted the largest genome-wide meta-analysis of borderline personality disorder (BPD) to date, with a discovery sample of 12,339 cases and 1,041,717 controls, and a replication study of 685 cases and 107,750 controls (all participant…
View article: Multi-omics profiling of DNA methylation and gene expression alterations in human cocaine use disorder
Multi-omics profiling of DNA methylation and gene expression alterations in human cocaine use disorder Open
View article: Direct and indirect genetic pathways between parental neuroticism and offspring emotional problems across development: evidence from 7 cohorts across 5 European nations
Direct and indirect genetic pathways between parental neuroticism and offspring emotional problems across development: evidence from 7 cohorts across 5 European nations Open
Disentangling direct and indirect genetic pathways underlying the intergenerational transmission of emotional problems could guide preventative strategies and further the understanding of the role of parental mental health in children’s ou…
View article: Cell type-specific Multi-Omics Analysis of Cocaine Use Disorder in the Human Caudate Nucleus
Cell type-specific Multi-Omics Analysis of Cocaine Use Disorder in the Human Caudate Nucleus Open
View article: Common polygenic variation in the early medication change (EMC) cohort affects disorder risk, but not the antidepressant treatment response
Common polygenic variation in the early medication change (EMC) cohort affects disorder risk, but not the antidepressant treatment response Open
The present study confirms a polygenic contribution to MDD burden in the EMC patients. Larger GWAS with homogeneity in antidepressant treatments are needed to explore the genetic variation associated with ADR and realize the potential of P…
View article: Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder
Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder Open
Background: Alcohol use disorder (AUD) is a complex condition associated with adverse health consequences that affect millions of individuals worldwide. Epigenetic modifications, including DNA methylation (5 mC), have been associated with …
View article: Speech Features as Predictors of Momentary Depression Severity in Patients With Depressive Disorder Undergoing Sleep Deprivation Therapy: Ambulatory Assessment Pilot Study
Speech Features as Predictors of Momentary Depression Severity in Patients With Depressive Disorder Undergoing Sleep Deprivation Therapy: Ambulatory Assessment Pilot Study Open
Background The use of mobile devices to continuously monitor objectively extracted parameters of depressive symptomatology is seen as an important step in the understanding and prevention of upcoming depressive episodes. Speech features su…
View article: Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex
Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex Open
Background Alcohol use disorder (AUD) has a profound public health impact. However, understanding of the molecular mechanisms underlying the development and progression of AUD remain limited. Here, we interrogate AUD-associated DNA methyla…
View article: Cell type-specific multi-omics analysis of cocaine use disorder in the human caudate nucleus
Cell type-specific multi-omics analysis of cocaine use disorder in the human caudate nucleus Open
View article: Development of a Fully Human Glioblastoma-in-Brain-Spheroid Model for Accelerated Translational Research
Development of a Fully Human Glioblastoma-in-Brain-Spheroid Model for Accelerated Translational Research Open
View article: Prenatal maternal stress and epigenome-wide placental DNA methylation in a prospective birth cohort study
Prenatal maternal stress and epigenome-wide placental DNA methylation in a prospective birth cohort study Open
View article: Common polygenic variation in the early medication change cohort affects risk of disorder, but not response to antidepressant treatment
Common polygenic variation in the early medication change cohort affects risk of disorder, but not response to antidepressant treatment Open
View article: Neuronal-specific methylome and hydroxymethylome analysis reveal replicated and novel loci associated with alcohol use disorder
Neuronal-specific methylome and hydroxymethylome analysis reveal replicated and novel loci associated with alcohol use disorder Open
1 Abstract Alcohol use disorder (AUD) is a complex condition associated with adverse health consequences that affect millions of individuals worldwide. Epigenetic modifications, including DNA methylation (5mC), have been associated with AU…
View article: GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors
GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors Open
This multi-ancestry analysis of suicide attempt identified several loci contributing to risk and establishes significant shared genetic covariation with clinical phenotypes. These findings provide insight into genetic factors associated wi…
View article: Evidence for a shared genetic contribution to loneliness and Borderline Personality Disorder
Evidence for a shared genetic contribution to loneliness and Borderline Personality Disorder Open
Loneliness, influenced by genetic and environmental factors such as childhood maltreatment, is one aspect of interpersonal dysfunction in Borderline Personality Disorder (BPD). Numerous studies link loneliness and BPD and twin studies indi…
View article: DNA methylation in cocaine use disorder–An epigenome-wide approach in the human prefrontal cortex
DNA methylation in cocaine use disorder–An epigenome-wide approach in the human prefrontal cortex Open
Background Cocaine use disorder (CUD) is characterized by a loss of control over cocaine intake and is associated with structural, functional, and molecular alterations in the human brain. At the molecular level, epigenetic alterations are…
View article: Capturing the biology of disease severity in an organoid model of LIS1-lissencephaly
Capturing the biology of disease severity in an organoid model of LIS1-lissencephaly Open
Lissencephaly is a malformation of cortical development (MCD) characterized by reduced to absent gyri and a disorganized cortex, leading to severe neurological consequences in affected individuals, including epilepsy, intellectual disabili…
View article: Polygenic risk scores for nicotine use and family history of smoking are associated with smoking behaviour
Polygenic risk scores for nicotine use and family history of smoking are associated with smoking behaviour Open
Introduction Formal genetics studies show that smoking is influenced by genetic factors; exploring this on the molecular level can offer deeper insight into the etiology of smoking behaviours. Methods Summary statistics from the GWAS and S…
View article: DNA Methylation in Cocaine Use Disorder – An Epigenome-wide Approach in the Human Prefrontal Cortex
DNA Methylation in Cocaine Use Disorder – An Epigenome-wide Approach in the Human Prefrontal Cortex Open
Cocaine use disorder (CUD) is characterized by a loss of control over drug intake and is associated with structural, functional, and molecular alterations in the brain. At the molecular level, epigenetic alterations are hypothesized to con…