Leah C. Katzelnick
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View article: Protective envelope dimer epitope–like antibodies are elicited against dengue virus in children after infection and vaccination
Protective envelope dimer epitope–like antibodies are elicited against dengue virus in children after infection and vaccination Open
Cross-reactive antibodies to epitopes that span envelope proteins on the virion surface are hypothesized to protect against dengue virus (DENV) infection and disease. Here, we measured antibodies targeting a quaternary epitope called the e…
View article: Zika virus vaccines and monoclonal antibodies: a priority agenda for research and development
Zika virus vaccines and monoclonal antibodies: a priority agenda for research and development Open
View article: Dengue virus IgG and neutralizing antibody titers measured with standard and mature viruses are protective
Dengue virus IgG and neutralizing antibody titers measured with standard and mature viruses are protective Open
View article: Human and hamster sera correlate well in identifying antigenic drift among SARS-CoV-2 variants, including JN.1
Human and hamster sera correlate well in identifying antigenic drift among SARS-CoV-2 variants, including JN.1 Open
Antigenic assessments of SARS-CoV-2 variants inform decisions to update COVID-19 vaccines. Primary infection sera are often used for assessments, but such sera are rare due to population immunity from SARS-CoV-2 infections and COVID-19 vac…
View article: High transmission of endemic human coronaviruses before and during the COVID-19 pandemic in adolescents in Cebu, Philippines
High transmission of endemic human coronaviruses before and during the COVID-19 pandemic in adolescents in Cebu, Philippines Open
To assess the seroprevalence and level of immunity to the four human coronaviruses (hCoVs) in healthy samples collected from children during the COVID-19 pandemic prior to vaccination and to test if differences in immunity to the hCoVs wer…
View article: Immunity to Non-Dengue Flaviviruses Impacts Dengue Virus Immunoglobulin G Enzyme-Linked Immunosorbent Assay Specificity in Cambodia
Immunity to Non-Dengue Flaviviruses Impacts Dengue Virus Immunoglobulin G Enzyme-Linked Immunosorbent Assay Specificity in Cambodia Open
Background Seroprevalence studies are the standard for disease surveillance, and serology determined eligibility for the first dengue vaccine. Expanding flavivirus co-circulation and vaccination complicate testing. We evaluate the accuracy…
View article: Primary exposure to Zika virus is linked with increased risk of symptomatic dengue virus infection with serotypes 2, 3, and 4, but not 1
Primary exposure to Zika virus is linked with increased risk of symptomatic dengue virus infection with serotypes 2, 3, and 4, but not 1 Open
Infection with any of the four dengue virus serotypes (DENV1–4) can protect against or enhance subsequent dengue depending on preexisting antibodies and infecting serotype. Additionally, primary infection with the related flavivirus Zika v…
View article: Comparative analysis of SARS-CoV-2 neutralization titers reveals consistency between human and animal model serum and across assays
Comparative analysis of SARS-CoV-2 neutralization titers reveals consistency between human and animal model serum and across assays Open
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires ongoing monitoring to judge the ability of newly arising variants to escape the immune response. A surveillance system necessitates an understanding of …
View article: Envelope-dimer epitope-like broadly protective antibodies against dengue in children following natural infection and vaccination
Envelope-dimer epitope-like broadly protective antibodies against dengue in children following natural infection and vaccination Open
Cross-reactive antibodies (Abs) to epitopes that span envelope proteins on the virion surface are hypothesized to protect against dengue. Here, we measured Abs targeting the quaternary envelope dimer epitope (EDE) as well as neutralizing a…
View article: Antigenic distance between primary and secondary dengue infections correlates with disease risk
Antigenic distance between primary and secondary dengue infections correlates with disease risk Open
Many pathogens continuously change their protein structure in response to immune-driven selection, resulting in weakened protection even in previously exposed individuals. In addition, for some pathogens, such as dengue virus, poorly targe…
View article: Increasing transmission of dengue virus across ecologically diverse regions of Ecuador and associated risk factors
Increasing transmission of dengue virus across ecologically diverse regions of Ecuador and associated risk factors Open
Data and associated code for: Increasing transmission of dengue virus across ecologically diverse regions of Ecuador and associated risk factors.
View article: Increasing transmission of dengue virus across ecologically diverse regions of Ecuador and associated risk factors
Increasing transmission of dengue virus across ecologically diverse regions of Ecuador and associated risk factors Open
<p>Data and associated code for: Increasing transmission of dengue virus across ecologically diverse regions of Ecuador and associated risk factors.</p>
View article: Dengue virus IgG and serotype-specific neutralizing antibody titers measured with standard and mature viruses are associated with protection
Dengue virus IgG and serotype-specific neutralizing antibody titers measured with standard and mature viruses are associated with protection Open
Recent work demonstrates the limitations of the standard dengue virus (DENV) neutralization assay to predict protection against dengue. We perform studies to compare how a commercial IgG ELISA, envelope domain III (EDIII) or non-structural…
View article: Antigenic cartography using hamster sera identifies SARS-CoV-2 JN.1 evasion seen in human XBB.1.5 booster sera
Antigenic cartography using hamster sera identifies SARS-CoV-2 JN.1 evasion seen in human XBB.1.5 booster sera Open
Antigenic assessments of SARS-CoV-2 variants inform decisions to update COVID-19 vaccines. Primary infection sera are often used for assessments, but such sera are rare due to population immunity from SARS-CoV-2 infections and COVID-19 vac…
View article: Effect of single-dose, live, attenuated dengue vaccine in children with or without previous dengue on risk of subsequent, virologically confirmed dengue in Cebu, the Philippines: a longitudinal, prospective, population-based cohort study
Effect of single-dose, live, attenuated dengue vaccine in children with or without previous dengue on risk of subsequent, virologically confirmed dengue in Cebu, the Philippines: a longitudinal, prospective, population-based cohort study Open
View article: Increasing transmission of dengue virus across ecologically diverse regions of Ecuador and associated risk factors
Increasing transmission of dengue virus across ecologically diverse regions of Ecuador and associated risk factors Open
The distribution and intensity of viral diseases transmitted by Aedes aegypti mosquitoes, including dengue, have rapidly increased over the last century. Here, we study dengue virus (DENV) transmission across the ecologically and demograph…
View article: Protection against symptomatic dengue infection by neutralizing antibodies varies by infection history and infecting serotype
Protection against symptomatic dengue infection by neutralizing antibodies varies by infection history and infecting serotype Open
View article: Protection against symptomatic dengue infection by neutralizing antibodies varies by infection history and infecting serotype
Protection against symptomatic dengue infection by neutralizing antibodies varies by infection history and infecting serotype Open
Dengue viruses (DENV1–4) are the most prevalent arboviruses in humans and a major public health concern. Understanding immune mechanisms that modulate DENV infection outcome is critical for vaccine development. Neutralizing antibodies (nAb…
View article: Primary exposure to Zika virus increases risk of symptomatic dengue virus infection with serotypes 2, 3, and 4 but not serotype 1
Primary exposure to Zika virus increases risk of symptomatic dengue virus infection with serotypes 2, 3, and 4 but not serotype 1 Open
Infection with any of the four dengue virus serotypes (DENV1-4) can protect against or enhance subsequent dengue depending on pre-existing antibodies and the subsequent infecting serotype. Additionally, primary infection with the related f…
View article: Severe dengue progression beyond enhancement
Severe dengue progression beyond enhancement Open
View article: Immunity to non-dengue flaviviruses impacts dengue virus IgG ELISA specificity in Cambodia
Immunity to non-dengue flaviviruses impacts dengue virus IgG ELISA specificity in Cambodia Open
Seroprevalence studies are the gold standard for disease surveillance, and serology was used to determine eligibility for the first licensed dengue vaccine. However, expanding flavivirus endemicity, co-circulation, and vaccination complica…
View article: High transmission of endemic human coronaviruses before and during the COVID-19 pandemic in adolescents in Cebu, Philippines
High transmission of endemic human coronaviruses before and during the COVID-19 pandemic in adolescents in Cebu, Philippines Open
View article: Effects of boosting and waning in highly exposed populations on dengue epidemic dynamics
Effects of boosting and waning in highly exposed populations on dengue epidemic dynamics Open
Sequential infection with multiple dengue virus (DENV) serotypes is thought to induce enduring protection against dengue disease. However, long-term antibody waning has been observed after repeated DENV infection. Here, we provide evidence…
View article: Comparative Analysis of SARS-CoV-2 Antigenicity across Assays and in Human and Animal Model Sera
Comparative Analysis of SARS-CoV-2 Antigenicity across Assays and in Human and Animal Model Sera Open
The antigenic evolution of SARS-CoV-2 requires ongoing monitoring to judge the immune escape of newly arising variants. A surveillance system necessitates an understanding of differences in neutralization titers measured in different assay…
View article: Antigenic diversity and dengue disease risk
Antigenic diversity and dengue disease risk Open
Many pathogens continuously change their protein structure in response to immune-driven selection, resulting in weakened protection. In addition, for some pathogens such as dengue virus, poorly targeted immunity is associated with increase…
View article: The association of neutralizing antibodies with protection against symptomatic dengue virus infection varies by serotype, prior infection history, and assay condition
The association of neutralizing antibodies with protection against symptomatic dengue virus infection varies by serotype, prior infection history, and assay condition Open
The four dengue virus serotypes (DENV1–4) are the most prevalent arboviruses in humans and a major public health concern worldwide. Understanding immune mechanisms that modulate DENV infection outcome is critical for epidemic preparedness …
View article: Increasing transmission of dengue virus across ecologically diverse regions of Ecuador and associated risk factors
Increasing transmission of dengue virus across ecologically diverse regions of Ecuador and associated risk factors Open
The distribution and intensity of viral diseases transmitted by Aedes aegypti mosquitoes, including dengue, have rapidly increased over the last century. Ecuador is an interesting country to study drivers of dengue virus (DENV) transmissio…
View article: Phase 1 trial to model primary, secondary, and tertiary dengue using a monovalent vaccine
Phase 1 trial to model primary, secondary, and tertiary dengue using a monovalent vaccine Open
View article: Differential dengue antibody responses in recipients of a Zika DNA vaccine are governed by dengue immune history
Differential dengue antibody responses in recipients of a Zika DNA vaccine are governed by dengue immune history Open
Dengue virus (DENV 1–4) and Zika virus (ZIKV) are closely related flaviviruses that induce immunological cross-reactivity. The VRC5283 Zika virus wild type DNA vaccine is the first to complete a Phase 2b trial (NCT03110770). The objective …
View article: Indirect IgG ELISA and serotype-specific neutralizing antibody titers are associated with protection against dengue in children in Cebu, Philippines
Indirect IgG ELISA and serotype-specific neutralizing antibody titers are associated with protection against dengue in children in Cebu, Philippines Open
Standard measures of dengue virus (DENV) antibodies have not been established as protective against dengue. We assess whether an indirect dengue IgG ELISA (PanBio; Brisbane, QLD, Australia) and serotype-specific neutralizing antibody titer…