Leah E. Cahill
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View article: Relationship between time-varying achieved HbA<sub>1c</sub> and risk of coronary artery disease events among common haptoglobin phenotype groups with type 2 diabetes: the ADVANCE study
Relationship between time-varying achieved HbA<sub>1c</sub> and risk of coronary artery disease events among common haptoglobin phenotype groups with type 2 diabetes: the ADVANCE study Open
Introduction This study sought to determine whether the association between attaining specific glycated hemoglobin (HbA 1c ) targets (<7.0% (<53 mmol/mol) and ≥8.0% (≥64 mmol/mol) compared with 7.0%–7.9%) over time and risk of incident cor…
View article: Examining the association of psychosocial and health behaviors with life satisfaction among canadians: a nationally representative study
Examining the association of psychosocial and health behaviors with life satisfaction among canadians: a nationally representative study Open
These findings underscore the importance of considering both psychosocial factors and physical health behaviors in understanding life dissatisfaction among Canadians. The results suggest that interventions targeting social factors, such as…
View article: Estimated inpatient malnutrition prevalence, screening tool utilization, and dietitian referral rates across hospitals during extension of phase 2 of More-2-Eat
Estimated inpatient malnutrition prevalence, screening tool utilization, and dietitian referral rates across hospitals during extension of phase 2 of More-2-Eat Open
Summary: Background & Aims: Malnutrition is associated with increased hospital length of stay, disease burden, and healthcare costs. The Integrated Nutrition Pathway for Acute Care (INPAC) is a validated multi-step algorithm that includes …
View article: The Relationship between Diet Costs and Dietary Adequacy: A Scoping Review of Measures and Methods with a Focus on Cost Estimation using Food Supply Data
The Relationship between Diet Costs and Dietary Adequacy: A Scoping Review of Measures and Methods with a Focus on Cost Estimation using Food Supply Data Open
In the absence of a standardized approach to study the relationship between diet costs and dietary adequacy, this scoping review has described methodological concepts and parameters used to price individuals' consumed diets. Our review sho…
View article: The relationship between repeated measurements of HbA1c and risk of coronary events among the common haptoglobin phenotype groups: the Action for Health in Diabetes (Look AHEAD) study
The relationship between repeated measurements of HbA1c and risk of coronary events among the common haptoglobin phenotype groups: the Action for Health in Diabetes (Look AHEAD) study Open
Background In the ACCORD study, participants with the haptoglobin (Hp) 2–2 phenotype and glycated hemoglobin (HbA 1c ) ≥ 8.0% had a higher risk of coronary artery disease (CAD) compared to those with HbA 1c 7.0–7.9%. However, this associat…
View article: Physician Perspectives on Malnutrition Screening, Diagnosis, and Management: A Qualitative Analysis
Physician Perspectives on Malnutrition Screening, Diagnosis, and Management: A Qualitative Analysis Open
Malnutrition is an important clinical entity that is frequently underdiagnosed and undertreated, in part due to a lack of education and different perceptions by healthcare providers on its value in medical practice. Given this void, the pu…
View article: Does the relationship between time-varying achieved HbA1c and risk of coronary events depend on haptoglobin phenotype within the Action for Health in Diabetes (Look AHEAD) study?
Does the relationship between time-varying achieved HbA1c and risk of coronary events depend on haptoglobin phenotype within the Action for Health in Diabetes (Look AHEAD) study? Open
Background Our previous research has identified the haptoglobin (Hp) phenotype as a potential biomarker that could be used to personalize glycemic control in type 2 diabetes mellitus (T2DM) to prevent coronary artery disease (CAD), the mos…
View article: Haptoglobin phenotype and intensive glycemic control for coronary artery disease risk reduction in people with type two diabetes: The Veterans Affairs Diabetes Trial
Haptoglobin phenotype and intensive glycemic control for coronary artery disease risk reduction in people with type two diabetes: The Veterans Affairs Diabetes Trial Open
The effect of intensive glycemic therapy on CAD events was not dependent on Hp phenotype in the VADT study of veterans with severe diabetes who may represent a population where Hp phenotype information would not be useful for personalizing…
View article: Co-Development of Three Dietary Indices to Facilitate Dietary Intake Assessment of Pediatric Crohn’s Disease Patients
Co-Development of Three Dietary Indices to Facilitate Dietary Intake Assessment of Pediatric Crohn’s Disease Patients Open
Literature on dietary behaviours of the pediatric Crohn’s Disease (CD) population and the relationship between dietary intake and CD activity is limited. Three dietary indices were developed and tested to conduct dietary pattern analysis i…
View article: Haptoglobin Phenotype and Intensive Glycemic Control for Coronary Artery Disease Risk Reduction in People With Type 2 Diabetes: The ADVANCE Study
Haptoglobin Phenotype and Intensive Glycemic Control for Coronary Artery Disease Risk Reduction in People With Type 2 Diabetes: The ADVANCE Study Open
OBJECTIVE Intensive glycemic control reduced coronary artery disease (CAD) events among the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study participants with the haptoglobin (Hp)2-2 phenotype but not in participants withou…
View article: Haptoglobin phenotype and intensive glycemic control for coronary artery disease risk reduction in people with type 2 diabetes: the ADVANCE study
Haptoglobin phenotype and intensive glycemic control for coronary artery disease risk reduction in people with type 2 diabetes: the ADVANCE study Open
Objective: Intensive glycemic control reduced coronary artery disease (CAD) events among the Action to Control Cardiovascular Disease Risk in Diabetes (ACCORD) study participants with the haptoglobin (Hp)2-2 phenotype, but not in participa…
View article: Haptoglobin phenotype and intensive glycemic control for coronary artery disease risk reduction in people with type 2 diabetes: the ADVANCE study
Haptoglobin phenotype and intensive glycemic control for coronary artery disease risk reduction in people with type 2 diabetes: the ADVANCE study Open
Objective: Intensive glycemic control reduced coronary artery disease (CAD) events among the Action to Control Cardiovascular Disease Risk in Diabetes (ACCORD) study participants with the haptoglobin (Hp)2-2 phenotype, but not in participa…
View article: National burden of rheumatoid arthritis in Canada, 1990–2019: findings from the Global Burden of Disease Study 2019 – a GBD collaborator-led study
National burden of rheumatoid arthritis in Canada, 1990–2019: findings from the Global Burden of Disease Study 2019 – a GBD collaborator-led study Open
Objective The objectives of this study were: (1) to describe burden of rheumatoid arthritis (RA) and trends from 1990 to 2019 using the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) data, (2) to describe age and sex diff…
View article: Developmental Trajectory of Body Weight in Youths at Risk for Major Mood Disorders
Developmental Trajectory of Body Weight in Youths at Risk for Major Mood Disorders Open
Importance Mood disorders are associated with increased body weight, especially in females, but it remains unknown when the weight increase starts. Objectives To examine sex-specific weight trajectories associated with familial mood disord…
View article: Dietary potassium liberalization with fruit and vegetables versus potassium restriction in people with chronic kidney disease (DK-Lib CKD): a clinical trial protocol
Dietary potassium liberalization with fruit and vegetables versus potassium restriction in people with chronic kidney disease (DK-Lib CKD): a clinical trial protocol Open
Background Potassium regulation in the body is primarily done in the kidney. In addition to this, hyperkalemia, occurs in approximately 10% of individuals with chronic kidney disease (CKD) and is associated with elevated all-cause mortalit…
View article: Relationship Between Time‐Varying Achieved High‐Density Lipoprotein Cholesterol and Risk of Coronary Events Depends on Haptoglobin Phenotype Within the ACCORD Lipid Study
Relationship Between Time‐Varying Achieved High‐Density Lipoprotein Cholesterol and Risk of Coronary Events Depends on Haptoglobin Phenotype Within the ACCORD Lipid Study Open
Background The Hp (haptoglobin)2‐2 phenotype (~40% of people) is associated with dysfunctional high‐density lipoprotein (HDL) that is heavily oxidized in hyperglycemia, which may explain why raising HDL‐cholesterol (HDL‐C) does not reliabl…
View article: Dietary Potassium liberalization with fruit and vegetables versus potassium restriction in people with Chronic Kidney Disease (DK-Lib CKD): a clinical trial protocol
Dietary Potassium liberalization with fruit and vegetables versus potassium restriction in people with Chronic Kidney Disease (DK-Lib CKD): a clinical trial protocol Open
Background: Potassium regulation in the body is primarily done in the kidney. In addition to this, hyperkalemia, occurs in approximately 10% of individuals with chronic kidney disease (CKD) and is associated with elevated all-cause mortali…
View article: The relationship between time-varying achieved HbA1c and risk of coronary events depends on haptoglobin phenotype among White and Black ACCORD participants
The relationship between time-varying achieved HbA1c and risk of coronary events depends on haptoglobin phenotype among White and Black ACCORD participants Open
Objective: Intensive glycemic therapy reduced coronary artery disease (CAD) events among White ACCORD study participants with the haptoglobin (Hp)2-2 phenotype, while participants without the Hp2-2 phenotype had no CAD benefit. The associa…
View article: The relationship between time-varying achieved HbA1c and risk of coronary events depends on haptoglobin phenotype among White and Black ACCORD participants
The relationship between time-varying achieved HbA1c and risk of coronary events depends on haptoglobin phenotype among White and Black ACCORD participants Open
Objective: Intensive glycemic therapy reduced coronary artery disease (CAD) events among White ACCORD study participants with the haptoglobin (Hp)2-2 phenotype, while participants without the Hp2-2 phenotype had no CAD benefit. The associa…
View article: Interrupting bedtime to reverse frailty levels in acute care: a study protocol for the Breaking Bad Rest randomized controlled trial
Interrupting bedtime to reverse frailty levels in acute care: a study protocol for the Breaking Bad Rest randomized controlled trial Open
Background Hospitalized older patients spend most of the waking hours in bed, even if they can walk independently. Excessive bedrest contributes to the development of frailty and worse hospital outcomes. We describe the study protocol for …
View article: A288 PHYSICIAN PERSPECTIVES OF MALNUTRITION CARE IN NOVA SCOTIA: A MORE-2-EAT (M2E) NOVA SCOTIA PHASE 2 QUALITATIVE SUBSTUDY
A288 PHYSICIAN PERSPECTIVES OF MALNUTRITION CARE IN NOVA SCOTIA: A MORE-2-EAT (M2E) NOVA SCOTIA PHASE 2 QUALITATIVE SUBSTUDY Open
Background Malnutrition is a clinical entity that is often underdiagnosed due to a lack of standard nutrition status screening during patient encounters, a lack of malnutrition education throughout medical training, inadequate resources to…
View article: Reducing Dietary Acid With Fruit and Vegetables Versus Oral Alkali in People With Chronic Kidney Disease (ReDACKD): A Clinical Research Protocol
Reducing Dietary Acid With Fruit and Vegetables Versus Oral Alkali in People With Chronic Kidney Disease (ReDACKD): A Clinical Research Protocol Open
Background: Individuals with chronic kidney disease (CKD) can develop metabolic acidosis which, in turn, is associated with faster progression of CKD and an increased need for dialysis. Oral sodium bicarbonate (the current standard of care…
View article: Relationship of body mass index with frailty and all-cause mortality among middle-aged and older adults
Relationship of body mass index with frailty and all-cause mortality among middle-aged and older adults Open
Background Parallel to growth of aging and obese populations, the prevalence of metabolic diseases is rising. How body mass index (BMI) relates to frailty and mortality across frailty levels is controversial. We examined the associations o…
View article: Many authors of publicly available top-selling nutrition books in Canada are without clinical nutrition credentials, do not cite evidence, and promote their own services or products
Many authors of publicly available top-selling nutrition books in Canada are without clinical nutrition credentials, do not cite evidence, and promote their own services or products Open
The accuracy of books as public nutrition resources varies substantially; whether authors of publicly available nutrition books possess related experience, cite scientific evidence, or have other financial incentives has not been assessed …
View article: Recent medical graduates’ attitudes towards nutrition education and its role in medical practice
Recent medical graduates’ attitudes towards nutrition education and its role in medical practice Open
The objective of this study was to investigate recent Dalhousie Medical School graduates’ perceptions of nutrition in three domains: attitudes towards its use in medical practice generally, learned body of knowledge in medical school and r…