Leah Herrgen
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View article: RNA-seq analysis and compound screening highlight multiple signalling pathways regulating secondary cell death after acute CNS injury<i>in vivo</i>
RNA-seq analysis and compound screening highlight multiple signalling pathways regulating secondary cell death after acute CNS injury<i>in vivo</i> Open
Understanding the molecular mechanisms that regulate secondary cell death after acute central nervous system (CNS) injury is critical for the development of effective neuroprotective drugs. Previous research has shown that neurotoxic proce…
View article: Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury <i>in vivo</i>
Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury <i>in vivo</i> Open
Moderate or severe traumatic brain injury (TBI) causes widespread neuronal cell death. Microglia, the resident macrophages of the brain, react to injury by migrating to the lesion site, where they phagocytose cellular debris. Microglial ph…
View article: Mapping neurogenesis onset in the optic tectum of <i>Xenopus laevis</i>
Mapping neurogenesis onset in the optic tectum of <i>Xenopus laevis</i> Open
Neural progenitor cells have a central role in the development and evolution of the vertebrate brain. During early brain development, neural progenitors first expand their numbers through repeated proliferative divisions and then begin to …