Leah Plasek
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View article: HIV infection reprogrammes CD4+ T cells for quiescence and entry into proviral latency
HIV infection reprogrammes CD4+ T cells for quiescence and entry into proviral latency Open
Human immunodeficiency virus (HIV) persists in infected individuals despite effective antiretroviral therapy due to the rapid establishment of latent reservoirs, mainly composed of quiescent memory CD4+ T cells. The mechanisms governing la…
View article: Overexpression of <i>Malat1</i> drives metastasis through inflammatory reprogramming of the tumor microenvironment
Overexpression of <i>Malat1</i> drives metastasis through inflammatory reprogramming of the tumor microenvironment Open
Expression of the long noncoding RNA (lncRNA) metastasis–associated lung adenocarcinoma transcript 1 ( MALAT1 ) correlates with tumor progression and metastasis in many tumor types. However, the impact and mechanism of action by which MALA…
View article: An HIV-induced mechanism for T cell quiescence andproviral latency
An HIV-induced mechanism for T cell quiescence andproviral latency Open
HIV persists in infected individuals despite effective antiretroviral therapy due to the rapid establishment of a latent HIV reservoir, mainly composed of quiescent memory CD4+ T cells1–3. The mechanisms governing the formation of the late…
View article: lncRNAs in T lymphocytes: RNA regulation at the heart of the immune response
lncRNAs in T lymphocytes: RNA regulation at the heart of the immune response Open
Genome-wide analyses in the last decade have uncovered the presence of a large number of long non-protein-coding transcripts that show highly tissue- and state-specific expression patterns. High-throughput sequencing analyses in diverse su…
View article: Long Non-Coding RNA-Mediated Regulation of the Interferon Response: A New Perspective on a Familiar Theme
Long Non-Coding RNA-Mediated Regulation of the Interferon Response: A New Perspective on a Familiar Theme Open
The interferon (IFN) response is a critical and ubiquitous component of the innate immune response to pathogens. Detailed studies in the last decades have elucidated the function of a large number of proteins that mediate the complex signa…