Leah R. Hanson
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View article: Facilitators and challenges in the implementation of the Care Ecosystem at six clinical sites in the United States: A qualitative study
Facilitators and challenges in the implementation of the Care Ecosystem at six clinical sites in the United States: A qualitative study Open
INTRODUCTION Collaborative care models with care navigation bridge medical and social needs in dementia care. These models, including the Care Ecosystem (CE), are being implemented at health systems and community‐based programs across the …
View article: Acupuncture Treatment for Individuals With Myasthenia Gravis – A Pilot Randomized Clinical Trial
Acupuncture Treatment for Individuals With Myasthenia Gravis – A Pilot Randomized Clinical Trial Open
Background Myasthenia gravis (MG) is a rare autoimmune disease resulting in muscle weakness. Although pharmacologic treatments are typically effective at managing symptoms, prolonged use is associated with safety issues. Acupuncture treatm…
View article: Intranasal insulin for the treatment of alcohol use disorder: design and methodology of an alcohol interaction randomized controlled trial
Intranasal insulin for the treatment of alcohol use disorder: design and methodology of an alcohol interaction randomized controlled trial Open
View article: Brain Glucose Hypometabolism and Brain Iron Accumulation as Therapeutic Targets for Alzheimer’s Disease and Other CNS Disorders
Brain Glucose Hypometabolism and Brain Iron Accumulation as Therapeutic Targets for Alzheimer’s Disease and Other CNS Disorders Open
Two common mechanisms contributing to multiple neurological disorders, including Alzheimer’s disease, are brain glucose hypometabolism (BGHM) and brain iron accumulation (BIA). Currently, BGHM and BIA are both widely acknowledged as biomar…
View article: Low-dose intranasal deferoxamine modulates memory, neuroinflammation, and the neuronal transcriptome in the streptozotocin rodent model of Alzheimer’s disease
Low-dose intranasal deferoxamine modulates memory, neuroinflammation, and the neuronal transcriptome in the streptozotocin rodent model of Alzheimer’s disease Open
Introduction Intranasal (IN) deferoxamine (DFO) has emerged over the past decade as a promising therapeutic in preclinical experiments across neurodegenerative and neurovascular diseases. As an antioxidant iron chelator, its mechanisms are…
View article: Open label pilot of personalized, neuroimaging-guided theta burst stimulation in early-stage Alzheimer’s disease
Open label pilot of personalized, neuroimaging-guided theta burst stimulation in early-stage Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is characterized by cerebral amyloid plaques and neurofibrillary tangles and disruption of large-scale brain networks (LSBNs). Transcranial magnetic stimulation (TMS) has emerged as a potential non-invas…
View article: A pilot pragmatic trial of Mindfulness Based Dementia Care for care partners
A pilot pragmatic trial of Mindfulness Based Dementia Care for care partners Open
Background Care partners (CPs) of people with dementia suffer from chronic stress impacting their mental and physical health. Mindfulness Based Stress Reduction (MBSR) has been shown to reduce depressive symptoms in CPs. Mindfulness‐Based …
View article: Development and validation of an electronic health record 3‐year risk model for diagnosis of dementia with and without Mini‐Cog scores
Development and validation of an electronic health record 3‐year risk model for diagnosis of dementia with and without Mini‐Cog scores Open
Background The number people living with Alzheimer’s disease and related dementias is expected to triple by 2050, contributing to decreased quality of life, increased medical care utilization, and additional burden on an already stressed p…
View article: ROLE OF GAIT SPEED, OLFACTION, AND PSYCHOLOGICAL FACTORS IN COGNITIVE FUNCTION AMONG OLDER ADULTS
ROLE OF GAIT SPEED, OLFACTION, AND PSYCHOLOGICAL FACTORS IN COGNITIVE FUNCTION AMONG OLDER ADULTS Open
Slowing of gait speed, loss of smell and increased depression, anxiety and stress have been associated with lower cognitive performance among older adults. The Minnesota Memory Project is a longitudinal study of community-dwelling adults 5…
View article: Employers most desirable attributes in early-career physiotherapists: a content analysis of job advertisements
Employers most desirable attributes in early-career physiotherapists: a content analysis of job advertisements Open
View article: Confidence in diagnosing and managing care for cognitive impairment in primary care: a survey comparing barriers by primary care clinician type
Confidence in diagnosing and managing care for cognitive impairment in primary care: a survey comparing barriers by primary care clinician type Open
Background As cognitive impairment (CI) prevalence rises and primary care screening becomes commonplace, it is critical to understand how to support clinicians. We describe clinician-reported barriers to diagnosing and managing care for pa…
View article: Implementation and review of the care ecosystem in an integrated healthcare system
Implementation and review of the care ecosystem in an integrated healthcare system Open
View article: Stroke Characteristics in a Cohort of Hmong American Patients
Stroke Characteristics in a Cohort of Hmong American Patients Open
Background Prior studies have indicated high rates of vascular risk factors, but little is known about stroke in Hmong. Methods and Results The institutional Get With The Guidelines (GWTG) database was used to identify patients discharged …
View article: Implementation and Review of the Care Ecosystem in an Integrated Healthcare System
Implementation and Review of the Care Ecosystem in an Integrated Healthcare System Open
Background and Objectives The University of California, San Francisco Memory and Aging Center (UCSF-MAC) led the development and tested a collaborative care model delivered by lay care team navigators (CTNs) with support from a multidiscip…
View article: Brain Glucose Hypometabolism and Iron Accumulation in Different Brain Regions in Alzheimer’s and Parkinson’s Diseases
Brain Glucose Hypometabolism and Iron Accumulation in Different Brain Regions in Alzheimer’s and Parkinson’s Diseases Open
The aim of this study was to examine the relationship between the presence of glucose hypometabolism (GHM) and brain iron accumulation (BIA), two potential pathological mechanisms in neurodegenerative disease, in different regions of the b…
View article: The application of the Human Connectome Project in large scale brain network imaging: A potential biomarker for Alzheimer's disease and related dementias
The application of the Human Connectome Project in large scale brain network imaging: A potential biomarker for Alzheimer's disease and related dementias Open
Background Alzheimer’s disease and related dementias (ADRD) result in progressive dysfunction of large scale brain networks (LSBNs) including the default mode network (DMN). Resting state functional MRI (rs‐fMRI) is an imaging tool offerin…
View article: Nasal oxytocin for the treatment of psychiatric disorders and pain: achieving meaningful brain concentrations
Nasal oxytocin for the treatment of psychiatric disorders and pain: achieving meaningful brain concentrations Open
View article: Losartan Improves Memory, Neurogenesis and Cell Motility in Transgenic Alzheimer’s Mice
Losartan Improves Memory, Neurogenesis and Cell Motility in Transgenic Alzheimer’s Mice Open
Angiotensin receptor blockers (ARBs) have demonstrated multiple neuroprotective benefits in Alzheimer’s disease (AD) models. However, their beneficial effects on memory deficits, cholinergic activity, neurogenesis and Amyloid beta (Aβ) cle…
View article: Mechanisms of Intranasal Deferoxamine in Neurodegenerative and Neurovascular Disease
Mechanisms of Intranasal Deferoxamine in Neurodegenerative and Neurovascular Disease Open
Identifying disease-modifying therapies for neurological diseases remains one of the greatest gaps in modern medicine. Herein, we present the rationale for intranasal (IN) delivery of deferoxamine (DFO), a high-affinity iron chelator, as a…
View article: A phase II, single center, randomized, double‐blind, placebo‐controlled study of the safety and therapeutic effectiveness of intranasal glulisine in amnestic mild cognitive impairment and probable mild Alzheimer’s disease
A phase II, single center, randomized, double‐blind, placebo‐controlled study of the safety and therapeutic effectiveness of intranasal glulisine in amnestic mild cognitive impairment and probable mild Alzheimer’s disease Open
Background IN insulin is a potential treatment for neurodegenerative disease shown to increase cerebral glucose update, reduce amyloid plaques and improve verbal memory in cognitively‐impaired as well as normal adults. Investigations have …
View article: Transforming Dementia Care Through Pragmatic Clinical Trials Embedded in Learning Healthcare Systems
Transforming Dementia Care Through Pragmatic Clinical Trials Embedded in Learning Healthcare Systems Open
The current evidence base for testing nonpharmacological interventions for people living with dementia (PLWD) and their caregivers is limited, especially within care settings such as ambulatory care, assisted living communities, nursing ho…
View article: Double-Blind Placebo-Controlled Pilot Investigation of the Safety of a Single Dose of Rapid-Acting Intranasal Insulin in Down Syndrome
Double-Blind Placebo-Controlled Pilot Investigation of the Safety of a Single Dose of Rapid-Acting Intranasal Insulin in Down Syndrome Open
View article: Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non‐disease‐specific pathway of functional neurologic improvement
Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non‐disease‐specific pathway of functional neurologic improvement Open
Introduction Intranasal deferoxamine (IN DFO) has been shown to decrease memory loss and have beneficial impacts across several models of neurologic disease and injury, including rodent models of Alzheimer's and Parkinson's disease. Method…
View article: Intranasal Insulin: a Treatment Strategy for Addiction
Intranasal Insulin: a Treatment Strategy for Addiction Open
View article: Unique Case Report of a Meningeal Sarcoma Arising during Ongoing Treatment for Progressing Intraparenchymal Glioma
Unique Case Report of a Meningeal Sarcoma Arising during Ongoing Treatment for Progressing Intraparenchymal Glioma Open
Radiation-induced sarcomas in the brain are extremely rare, usually occur with an average latency of 9 years, and are associated with poor outcomes. Latency periods shorter than 1 year may indicate a genetic predisposition such as Li-Fraum…
View article: IMPLEMENTATION OF A MINDFULNESS BASED DEMENTIA-CARE PROGRAM WITHIN A HEALTHCARE SYSTEM
IMPLEMENTATION OF A MINDFULNESS BASED DEMENTIA-CARE PROGRAM WITHIN A HEALTHCARE SYSTEM Open
The stress associated with caring for a loved one with Alzheimer’s disease or a related dementia can negatively affect mental and physical health. Mindfulness-based stress reduction (MBSR), teaching caregivers to focus on the present momen…
View article: P3‐011: A DOUBLE‐BLIND, PLACEBO‐CONTROLLED PILOT INVESTIGATION OF THE SAFETY OF INTRANASAL GLULISINE IN DOWN SYNDROME
P3‐011: A DOUBLE‐BLIND, PLACEBO‐CONTROLLED PILOT INVESTIGATION OF THE SAFETY OF INTRANASAL GLULISINE IN DOWN SYNDROME Open
Individuals with Down Syndrome (DS) are likely to develop clinical and neuropathological brain changes resembling Alzheimer's dementia by the ages of 35–40 years, which include deposits of extracellular amyloid-beta oligomers (Aβ) and intr…
View article: Correction to: The AGING Initiative experience: a call for sustained support for team science networks
Correction to: The AGING Initiative experience: a call for sustained support for team science networks Open
View article: Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats
Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats Open
View article: Solitary bone plasmacytoma compression injury disguised as back pain: a case report
Solitary bone plasmacytoma compression injury disguised as back pain: a case report Open