Leah M. Ziolkowski
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View article: Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer
Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer Open
Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due to primary or rapidly acquired chemore…
View article: A prometabolite strategy inhibits cardiometabolic disease in an ApoE–/– murine model of atherosclerosis
A prometabolite strategy inhibits cardiometabolic disease in an ApoE–/– murine model of atherosclerosis Open
Butyrate, a microbiome-derived short-chain fatty acid with pleiotropic effects on inflammation and metabolism, has been shown to significantly reduce atherosclerotic lesions, rectify routine metabolic parameters such as low-density lipopro…