Leander Blaas
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View article: Tumour-derived LAMA5 is critical for tumour initiation and controls progression and phenotype in luminal breast cancer
Tumour-derived LAMA5 is critical for tumour initiation and controls progression and phenotype in luminal breast cancer Open
Basement membrane (BM) supports and regulates the structural integrity, function and differentiation of epithelial tissues and protects against stromal invasion of breast cancer cells. Here we show that LAMA5, a central BM component, is cr…
View article: Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation and Wnt4-mediated epithelial crosstalk
Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation and Wnt4-mediated epithelial crosstalk Open
Epithelial attachment to the basement membrane (BM) is essential for mammary gland development, yet the exact roles of specific BM components remain unclear. Here, we show that Laminin α5 (Lama5) expression specifically in the luminal epit…
View article: Laminin alpha 5 is Necessary for Mammary Epithelial Growth and Function by Maintaining Luminal Epithelial Cell Identity
Laminin alpha 5 is Necessary for Mammary Epithelial Growth and Function by Maintaining Luminal Epithelial Cell Identity Open
Epithelial attachment to the basement membrane (BM) is essential for mammary gland development, yet the exact roles of specific BM components remain unclear. Here, we demonstrate that expression of distinct laminin α-isoforms by luminal an…
View article: A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions
A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions Open
Genetically-engineered mouse models (GEMMs) lacking diseased-associated gene(s) globally or in a tissue-specific manner represent an attractive tool with which to assess the efficacy and toxicity of targeted pharmacological inhibitors. Sta…
View article: Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth
Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth Open
The gene desert upstream of the MYC oncogene on chromosome 8q24 contains susceptibility loci for several major forms of human cancer. The region shows high conservation between human and mouse and contains multiple MYC enhancers that are a…
View article: Author response: Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth
Author response: Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract The gene desert up…
View article: Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours
Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours Open
The mammary gland is composed of a complex cellular hierarchy with unusual postnatal plasticity. The identities of stem/progenitor cell populations, as well as tumour-initiating cells that give rise to breast cancer, are incompletely under…
View article: Mice deficient of<i>Myc</i>super-enhancer region reveal a differential control mechanism between normal and pathological growth
Mice deficient of<i>Myc</i>super-enhancer region reveal a differential control mechanism between normal and pathological growth Open
The gene desert upstream of the Myc oncogene on chromosome 8q24 contains susceptibility loci for several major forms of human cancer, including cancers of breast, prostate, and colon. The region shows high conservation between human and mo…
View article: Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis
Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis Open
STAT3 is considered to play an oncogenic role in several malignancies including lung cancer; consequently, targeting STAT3 is currently proposed as therapeutic intervention. Here we demonstrate that STAT3 plays an unexpected tumour-suppres…