Leandro B. C. Teixeira
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View article: Feline Conjunctival Sequestra—A Case Series
Feline Conjunctival Sequestra—A Case Series Open
Purpose Corneal sequestrum is a condition commonly observed in cats, though the pathogenesis is not fully understood. The occurrence of conjunctival sequestrum has not previously been documented. This report aims to describe a series of ca…
View article: Safety and biocompatibility of a novel biodegradable aflibercept-drug delivery system in rhesus macaques
Safety and biocompatibility of a novel biodegradable aflibercept-drug delivery system in rhesus macaques Open
A clinical need exists for more effective intravitreal (IVT) drug delivery systems (DDS). This study tested the hypothesis that a novel biodegradable, injectable microsphere-hydrogel drug delivery system loaded with aflibercept (aflibercep…
View article: Clinical and morphological features of corneal lymphoma in 26 horses (27 eyes)
Clinical and morphological features of corneal lymphoma in 26 horses (27 eyes) Open
Background Little information describing the biologic behaviour and therapies for corneal lymphoma exist. Objectives To characterise histologically confirmed equine corneal lymphoma considering breed, age or sex predisposition, histologic …
View article: Trabecular Meshwork Abnormalities in a Model of Congenital Glaucoma Due to <i>LTBP2</i> Mutation
Trabecular Meshwork Abnormalities in a Model of Congenital Glaucoma Due to <i>LTBP2</i> Mutation Open
In this feline model of PCG due to LTBP2 mutation, development of ultrastructural TM extracellular matrix abnormalities are first observed by 2 weeks and cellular abnormalities by 5 weeks of age. By 12 weeks of age, when intraocular pressu…
View article: International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of Nonrodent Ocular Tissues
International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of Nonrodent Ocular Tissues Open
The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions) Project ( www.toxpath.org/ inhand.asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), J…
View article: Intraocular osseous metaplasia in an older red‐tailed hawk (<i>Buteo jamaicensis</i>) 24 years following traumatic injury to the globe
Intraocular osseous metaplasia in an older red‐tailed hawk (<i>Buteo jamaicensis</i>) 24 years following traumatic injury to the globe Open
An approximately 26‐year‐old, suspected female, red‐tailed hawk ( Buteo jamaicensis ) was presented with a history of chronic ocular changes of the left eye likely secondary to blunt trauma resulting in blindness and phthisis bulbi. Ophtha…
View article: Assessment of Early Glaucomatous Optic Neuropathy in the Dog by Spectral Domain Optical Coherence Tomography (SD-OCT)
Assessment of Early Glaucomatous Optic Neuropathy in the Dog by Spectral Domain Optical Coherence Tomography (SD-OCT) Open
Background: Inherited primary open-angle glaucoma (POAG) in Beagle dogs is a well-established large animal model of glaucoma and is caused by a G661R missense mutation in the ADAMTS10 gene. Using this model, the study describes early clini…
View article: Clinicopathologic profiles of canine ocular melanosis: A comparative study between cairn terriers and non‐cairn terriers
Clinicopathologic profiles of canine ocular melanosis: A comparative study between cairn terriers and non‐cairn terriers Open
Objective s To identify canine breeds at risk for ocular melanosis and to compare the clinical and histologic features between affected Cairn Terriers (CTs) and non‐Cairn Terriers (NCTs). Design Relative risk (RR) analysis and retrospectiv…
View article: Iridial melanocytoma in a ferruginous hawk (<i>Buteo regalis</i>): A case report and review of avian melanocytic neoplasia
Iridial melanocytoma in a ferruginous hawk (<i>Buteo regalis</i>): A case report and review of avian melanocytic neoplasia Open
A 21‐year‐old, suspected female captive ferruginous hawk ( Buteo regalis ) was followed for 3 years due to an iridial mass of the left eye (OS) that progressively increased in size. Enucleation of OS was eventually recommended due to the i…
View article: Clinical and histopathological features of proliferative corneal lesions in <i>Cyprininae</i> fishes: Implications for treatment and insights into corneal tumors
Clinical and histopathological features of proliferative corneal lesions in <i>Cyprininae</i> fishes: Implications for treatment and insights into corneal tumors Open
Captive fish populations, such as those encompassing aquarium and pet fish, offer significant economic value and are integral to conservation, research, and education. However, these ornamental fish exhibit a reduced ability to protect the…
View article: Collagen crosslinking impacts stromal wound healing and haze formation in a rabbit phototherapeutic keratectomy model.
Collagen crosslinking impacts stromal wound healing and haze formation in a rabbit phototherapeutic keratectomy model. Open
We showed that stromal haze formation and stromal stiffness is significantly increased following CXL, regardless of whether it is performed at or before the time of PTK. Further knowledge of the biophysical cues involved in determining cor…
View article: Atypical chorioretinal lesions in Siberian Husky dogs with primary angle-closure glaucoma: a case series
Atypical chorioretinal lesions in Siberian Husky dogs with primary angle-closure glaucoma: a case series Open
Background A number of etiologies for different canine chorioretinal lesions have been proved or suggested but some fundic lesions remain unclear in terms of an etiologic diagnosis, treatment options and prognosis. The purpose of this case…
View article: Pathology in Practice
Pathology in Practice Open
In collaboration with the American College of Veterinary Pathologists
View article: Pathology in Practice
Pathology in Practice Open
In collaboration with the American College of Veterinary Pathologists
View article: Bifunctional Peptide that Anneals to Damaged Collagen and Clusters TGF-β Receptors Enhances Wound Healing
Bifunctional Peptide that Anneals to Damaged Collagen and Clusters TGF-β Receptors Enhances Wound Healing Open
Transforming growth factor-β (TGF-β) plays important roles in wound healing. The activity of TGF-β is initiated upon the binding of the growth factor to the extracellular domains of its receptors. We sought to facilitate the activation by …
View article: Pathology in Practice
Pathology in Practice Open
In collaboration with the American College of Veterinary Pathologists
View article: Development and validation of methods to visualize conventional aqueous outflow pathways in canine primary angle closure glaucoma
Development and validation of methods to visualize conventional aqueous outflow pathways in canine primary angle closure glaucoma Open
Purpose Angle closure glaucoma (PACG) is highly prevalent in dogs and is often refractory to medical therapy. We hypothesized that pathology affecting the post‐trabecular conventional aqueous outflow pathway contributes to persistent intra…
View article: Bifunctional Peptide that Anneals to Damaged Collagen and Clusters TGF-β Receptors Enhances Wound Healing
Bifunctional Peptide that Anneals to Damaged Collagen and Clusters TGF-β Receptors Enhances Wound Healing Open
Transforming growth factor-β (TGF-β) plays important roles in wound healing. The activity of TGF-β is initiated upon binding of the growth factor to extracellular domains of its receptors. We sought to facilitate activation by clustering t…
View article: Changing the Wound: Covalent Immobilization of the Epidermal Growth Factor
Changing the Wound: Covalent Immobilization of the Epidermal Growth Factor Open
Re-epithelialization of wounds is a critical element of wound closure. Growth factors have been used in combination with conventional wound management to promote closure, but the method of delivery has been limited to the topical applicati…
View article: Mapping retinal ganglion cell somas in a large-eyed glaucoma model.
Mapping retinal ganglion cell somas in a large-eyed glaucoma model. Open
As in other species, RGC soma count and topography are heterogeneous between individual cats, but we identified an ROI in the temporal retina for future studies of RGC soma loss or preservation in a large-eyed model of congenital glaucoma.…
View article: Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus
Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus Open
Congenital Zika virus (ZIKV) exposure results in a spectrum of disease ranging from severe birth defects to delayed onset neurodevelopmental deficits. ZIKV-related neuropathogenesis, predictors of birth defects, and neurodevelopmental defi…
View article: Safety and Biocompatibility of Aflibercept-Loaded Microsphere Thermo-Responsive Hydrogel Drug Delivery System in a Nonhuman Primate Model
Safety and Biocompatibility of Aflibercept-Loaded Microsphere Thermo-Responsive Hydrogel Drug Delivery System in a Nonhuman Primate Model Open
Aflibercept-DDS may be a more effective method to deliver bioactive antivascular endothelial growth factor agents than current practice by reducing the frequency of intravitreal injections and providing controlled drug release.
View article: A novel cellular structure in the retina of insectivorous birds
A novel cellular structure in the retina of insectivorous birds Open
The keen visual systems of birds have been relatively well-studied. The foundations of avian vision rest on their cone and rod photoreceptors. Most birds use four cone photoreceptor types for color vision, a fifth cone for achromatic tasks…
View article: Imaging Distal Aqueous Outflow Pathways in a Spontaneous Model of Congenital Glaucoma
Imaging Distal Aqueous Outflow Pathways in a Spontaneous Model of Congenital Glaucoma Open
This report provides histopathologic correlates of advanced diagnostic imaging findings in a spontaneous model of congenital glaucoma.
View article: 2784. Increased Frontal Lobe Volume and Density in Macaques Exposed to Zika Virus In Utero
2784. Increased Frontal Lobe Volume and Density in Macaques Exposed to Zika Virus In Utero Open
Background In utero Zika virus (ZIKV) infection causes birth defects and neurodevelopmental deficits in neonates. We reasoned that a translational macaque model of congenital ZIKV infection could define disease pathophysiology not possible…