Érica Leandro Marciano Vieira
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View article: Extracellular Vesicles as Biomarkers of Brain Cellular Dynamics: Applications in Alzheimer's Dementia, Mild Cognitive Impairment and Late‐Life Depression
Extracellular Vesicles as Biomarkers of Brain Cellular Dynamics: Applications in Alzheimer's Dementia, Mild Cognitive Impairment and Late‐Life Depression Open
Background Exosomes from brain cells, such as neuron‐derived (NDEs) and astrocyte‐derived exosomes (ADEs), can cross the blood‐brain barrier and be detected in peripheral circulation. These vesicles facilitate communication between the cen…
View article: Brain-derived neurotrophic factor prevents LPS-induced dysregulation of GABAergic interneuron markers in mouse hippocampus
Brain-derived neurotrophic factor prevents LPS-induced dysregulation of GABAergic interneuron markers in mouse hippocampus Open
Background Inflammation causes reduced markers of GABAergic interneurons and brain-derived neurotrophic factor (BDNF) in the hippocampus, features often associated with neuropsychiatric disease pathophysiology. However, the mechanism conne…
View article: Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program
Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program Open
Substance use disorders (SUDs), including Alcohol Use Disorder, are pressing global public health problems. Executive functions (EFs) are prominently featured in mechanistic models of addiction. However, significant gaps remain in our unde…
View article: Blood Angiogenesis Markers and Cognition in Older Adults at Risk for Dementia: Marqueurs sanguins de l’angiogenèse et cognition chez les personnes âgées à risque de démence
Blood Angiogenesis Markers and Cognition in Older Adults at Risk for Dementia: Marqueurs sanguins de l’angiogenèse et cognition chez les personnes âgées à risque de démence Open
Objective Changes in angiogenesis have been shown to contribute to cognitive decline and dementia. We aimed to identify angiogenesis blood markers associated with cognitive performance in older adults with mild cognitive impairment (MCI), …
View article: Enhancing Post-Training Muscle Recovery and Strength in Paralympic Powerlifting Athletes with Cold-Water Immersion, a Cross-Sectional Study
Enhancing Post-Training Muscle Recovery and Strength in Paralympic Powerlifting Athletes with Cold-Water Immersion, a Cross-Sectional Study Open
(1) Background: The recovery method is important and decisive in the training system. This study aimed to assess the effects of various post-training recovery methods on muscle damage and strength indicators in Paralympic powerlifting athl…
View article: Strength Training can Modulate Urinary Adipokine Levels in Healthy Young Males
Strength Training can Modulate Urinary Adipokine Levels in Healthy Young Males Open
Adipose tissue stores energy in fat-rich adipocytes, which can produce and release several adipokines and modulate body metabolism. Exercise may induce adipokine production in adipocytes; however, the relationship between the two remains u…
View article: Expression of immunophenotypic markers in blood mononuclear cells of patients with advanced head and neck squamous cells carcinoma
Expression of immunophenotypic markers in blood mononuclear cells of patients with advanced head and neck squamous cells carcinoma Open
Purpose: To evaluate peripheral blood mononuclear cells (PBMCs) from patients with advanced head and neck squamous cell carcinoma (HNSCC) in comparison with healthy volunteers, as they can be potential biomarkers. Methods: Immunophenotypin…
View article: INTERSECTIONALITY, MENTAL HEALTH AND THE REMAINING BLACK POPULATION OF QUILOMBO: THE NECROPOLITICS OF INVISIBILITY AND ABANDONMENT
INTERSECTIONALITY, MENTAL HEALTH AND THE REMAINING BLACK POPULATION OF QUILOMBO: THE NECROPOLITICS OF INVISIBILITY AND ABANDONMENT Open
Mental health problems are a global public health problem, with Brazil having the highest prevalence of depression and the second highest prevalence in the Americas (WHO, 2022). However, mental health problems do not occur homogeneously ac…
View article: Enhancing Post-Training Muscle Recovery and Strength in Paralympic Powerlifting Athletes with Cold-Water Immersion
Enhancing Post-Training Muscle Recovery and Strength in Paralympic Powerlifting Athletes with Cold-Water Immersion Open
(1) Background: The recovery method would be important and decisive in the training system. This study aimed to assess the effects of various post-training recovery methods on muscle damage and strength indicators in Paralympic powerliftin…
View article: Astrogliosis Marker [11C]SL25.1188 After COVID-19 With Ongoing Depressive and Cognitive Symptoms
Astrogliosis Marker [11C]SL25.1188 After COVID-19 With Ongoing Depressive and Cognitive Symptoms Open
Results strongly support the presence of monoamine oxidase B-labeled astrogliosis in COVID-DC throughout the regions assessed, although the association of greater astrogliosis with fewer symptoms raises the possibility of a protective role…
View article: Cognitive Dysfunction in the Addictions (CDiA): A Neuron to Neighbourhood Collaborative Research Program on Executive Dysfunction and Functional Outcomes in Outpatients Seeking Treatment for Addiction
Cognitive Dysfunction in the Addictions (CDiA): A Neuron to Neighbourhood Collaborative Research Program on Executive Dysfunction and Functional Outcomes in Outpatients Seeking Treatment for Addiction Open
Background: Substance use disorders (SUDs) are pressing global public health problems. Executive functions (EFs) are prominently featured in mechanistic models of addiction. However, there remain significant gaps in our understanding of EF…
View article: LPS-induced inflammation reduces GABAergic interneuron markers and brain-derived neurotrophic factor in mouse prefrontal cortex and hippocampus
LPS-induced inflammation reduces GABAergic interneuron markers and brain-derived neurotrophic factor in mouse prefrontal cortex and hippocampus Open
Inflammation, reduced gamma-aminobutyric acidergic (GABAergic) function and altered neuroplasticity are co-occurring pathophysiologies in major depressive disorder (MDD). However, the link between these biological changes remains unclear. …
View article: The PACt‐MD randomized clinical trial: Prevention of Alzheimer’s dementia with Cognitive remediation plus transcranial direct current stimulation in Mild cognitive impairment and Depression
The PACt‐MD randomized clinical trial: Prevention of Alzheimer’s dementia with Cognitive remediation plus transcranial direct current stimulation in Mild cognitive impairment and Depression Open
Background Interventions to prevent cognitive decline and dementia in high‐risk populations such as those with remitted Major Depressive Disorder (rMDD) or Mild Cognitive Impairment (MCI) are urgently needed. Method PACt‐MD was a double‐bl…
View article: LPS-Induced Inflammation Reduces GABAergic Interneuron markers and Brain-derived Neurotrophic Factor in Mouse Prefrontal Cortex and Hippocampus
LPS-Induced Inflammation Reduces GABAergic Interneuron markers and Brain-derived Neurotrophic Factor in Mouse Prefrontal Cortex and Hippocampus Open
Inflammation, reduced gamma-aminobutyric acidergic (GABAergic) function and altered neuroplasticity are co-occurring pathophysiologies in major depressive disorder (MDD). However, the link between these biological changes remains unclear. …
View article: Neuroimaging and Biosample Collection in the Toronto Adolescent and Youth Cohort Study: Rationale, Methods, and Early Data
Neuroimaging and Biosample Collection in the Toronto Adolescent and Youth Cohort Study: Rationale, Methods, and Early Data Open
The high consent rates, good completion rates, and high data usability reported here demonstrate the feasibility of collecting and using brain imaging and biosamples in a large clinical cohort of youths seeking mental health care.
View article: The effects of Phycocyanobilin on experimental arthritis involve the reduction in nociception and synovial neutrophil infiltration, inhibition of cytokine production, and modulation of the neuronal proteome
The effects of Phycocyanobilin on experimental arthritis involve the reduction in nociception and synovial neutrophil infiltration, inhibition of cytokine production, and modulation of the neuronal proteome Open
Introduction The antinociceptive and pharmacological activities of C-Phycocyanin (C-PC) and Phycocyanobilin (PCB) in the context of inflammatory arthritis remain unexplored so far. In the present study, we aimed to assess the protective ac…
View article: GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential
GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential Open
Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use…
View article: Astrogliosis marker 11C-SL25.1188 PET in traumatic brain injury with persistent symptoms
Astrogliosis marker 11C-SL25.1188 PET in traumatic brain injury with persistent symptoms Open
Traumatic brain injury (TBI) is common but little is known why up to a third of patients have persisting symptoms. Astrogliosis, a pathophysiological response to brain injury, may be a potential therapeutic target, but demonstration of ast…
View article: Neuroinflammation After COVID-19 With Persistent Depressive and Cognitive Symptoms
Neuroinflammation After COVID-19 With Persistent Depressive and Cognitive Symptoms Open
Importance Persistent depressive symptoms, often accompanied by cognitive symptoms, commonly occur after COVID-19 illness (hereinafter termed COVID-DC , DC for depressive and/or cognitive symptoms). In patients with COVID-DC, gliosis, an i…
View article: Evaluation of New Potential Inflammatory Markers in Patients with Nonvalvular Atrial Fibrillation
Evaluation of New Potential Inflammatory Markers in Patients with Nonvalvular Atrial Fibrillation Open
Atrial fibrillation (AF), the most common arrhythmia in clinical practice, is associated with an increase in mortality and morbidity due to its high potential to cause stroke and systemic thromboembolism. Inflammatory mechanisms may play a…
View article: Anti-inflammatory mechanisms and pharmacological actions of phycocyanobilin in a mouse model of experimental autoimmune encephalomyelitis: A therapeutic promise for multiple sclerosis
Anti-inflammatory mechanisms and pharmacological actions of phycocyanobilin in a mouse model of experimental autoimmune encephalomyelitis: A therapeutic promise for multiple sclerosis Open
Cytokines, demyelination and neuroaxonal degeneration in the central nervous system are pivotal elements implicated in the pathogenesis of multiple sclerosis (MS) and its nonclinical model of experimental autoimmune encephalomyelitis (EAE)…
View article: Higher IL-6 and IL-4 plasma levels in depressed elderly women are influenced by diabetes mellitus
Higher IL-6 and IL-4 plasma levels in depressed elderly women are influenced by diabetes mellitus Open
Diabetes influences the association between MDD and higher levels of cytokines in elderly female patients. Future studies should take this evidence into account in order to mitigate confounding factors.