Leanna M.W. Lui
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View article: The mediational role of cognitive function on occupational outcomes in persons with major depressive and bipolar disorder
The mediational role of cognitive function on occupational outcomes in persons with major depressive and bipolar disorder Open
Background Improving functioning in adults with major depressive disorder (MDD) and bipolar disorder (BD) is a priority therapeutic objective. Methods This retrospective post hoc secondary analysis evaluated 108 patients with MDD or BD rec…
View article: Corrigendum to “COVID-19 vaccination for the prevention and treatment of long COVID: A systematic review and meta-analysis” [Brain Behav. Immun. 111 (2023) 211–229]
Corrigendum to “COVID-19 vaccination for the prevention and treatment of long COVID: A systematic review and meta-analysis” [Brain Behav. Immun. 111 (2023) 211–229] Open
View article: COVID-19 vaccination for the prevention and treatment of long COVID: A systematic review and meta-analysis
COVID-19 vaccination for the prevention and treatment of long COVID: A systematic review and meta-analysis Open
View article: Presence of Depression Is Associated with Functional Impairment in Middle-Aged and Elderly Chinese Adults with Vascular Disease/Diabetes Mellitus—A Cross-Sectional Study
Presence of Depression Is Associated with Functional Impairment in Middle-Aged and Elderly Chinese Adults with Vascular Disease/Diabetes Mellitus—A Cross-Sectional Study Open
Objectives: The association between chronic diseases and depression has received increasing attention, and are both considered to increase the risk of functional impairment. However, previous research evidence is controversial. Our study a…
View article: A Research Domain Criteria (RDoC)-Guided Dashboard to Review Psilocybin Target Domains: A Systematic Review
A Research Domain Criteria (RDoC)-Guided Dashboard to Review Psilocybin Target Domains: A Systematic Review Open
View article: Screening Depressive Symptoms and Incident Major Depressive Disorder Among Chinese Community Residents Using a Mobile App–Based Integrated Mental Health Care Model: Cohort Study
Screening Depressive Symptoms and Incident Major Depressive Disorder Among Chinese Community Residents Using a Mobile App–Based Integrated Mental Health Care Model: Cohort Study Open
Background Depression is associated with significant morbidity and human capital costs globally. Early screening for depressive symptoms and timely depressive disorder case identification and intervention may improve health outcomes and co…
View article: The efficacy and safety of adjunctive intranasal esketamine treatment in major depressive disorder: a systematic review and meta-analysis
The efficacy and safety of adjunctive intranasal esketamine treatment in major depressive disorder: a systematic review and meta-analysis Open
Intranasal (IN) esketamine represents an innovative treatment for individuals with treatment resistant depression and depression with suicidal ideation and behavior. Herein, we synthesize extant long-term studies (≥ 4 weeks) regarding this…
View article: Registered clinical trials investigating treatment of long COVID: a scoping review and recommendations for research
Registered clinical trials investigating treatment of long COVID: a scoping review and recommendations for research Open
The results of this scoping review investigating ongoing clinical trials testing candidate treatments for long COVID suggest that a greater degree of definitional stringency and homogeneity is needed insofar as the characterization of long…
View article: Immune response to vaccination in adults with mental disorders: A systematic review
Immune response to vaccination in adults with mental disorders: A systematic review Open
View article: Hallucinogen persisting perceptual disorder: a scoping review covering frequency, risk factors, prevention, and treatment
Hallucinogen persisting perceptual disorder: a scoping review covering frequency, risk factors, prevention, and treatment Open
Hallucinogen persisting perception disorder (HPPD) affects a subset of persons who use hallucinogens and is defined as the repeated experience of hallucinations and other perceptual disturbances as a result of prior intoxications. As selec…
View article: Canadian Healthcare System and Individuals with Severe Mental Disorders During Coronavirus Disease 2019: Challenges and Unmet Needs
Canadian Healthcare System and Individuals with Severe Mental Disorders During Coronavirus Disease 2019: Challenges and Unmet Needs Open
The Coronavirus Disease 2019 (COVID-19) pandemic is a syndemic of viral infection and mental health adversity. The pandemic has exacerbated inequalities of access to care in vulnerable populations within the Canadian mental healthcare syst…
View article: Registered clinical trials investigating treatment of long COVID: a scoping review and recommendations for research
Registered clinical trials investigating treatment of long COVID: a scoping review and recommendations for research Open
A considerable proportion of individuals report persistent, debilitating and disparate symptoms despite resolution of acute COVID-19 infection (i.e. long COVID). Numerous registered clinical trials investigating treatment of long COVID are…
View article: Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis
Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis Open
View article: Social Isolation, Loneliness and Generalized Anxiety: Implications and Associations during the COVID-19 Quarantine
Social Isolation, Loneliness and Generalized Anxiety: Implications and Associations during the COVID-19 Quarantine Open
The COVID-19 pandemic has resulted in a predominantly global quarantine response that has been associated with social isolation, loneliness, and anxiety. The foregoing experiences have been amply documented to have profound impacts on heal…
View article: The Association Between Concentrations of Arginine, Ornithine, Citrulline and Major Depressive Disorder: A Meta-Analysis
The Association Between Concentrations of Arginine, Ornithine, Citrulline and Major Depressive Disorder: A Meta-Analysis Open
Alterations in the peripheral (e.g., serum, plasma, platelet) concentrations of arginine and its related catabolic products (i.e., ornithine, citrulline) in the urea and nitric oxide cycles have been reported to be associated with major de…
View article: Onset and frequency of depression in post-COVID-19 syndrome: A systematic review
Onset and frequency of depression in post-COVID-19 syndrome: A systematic review Open
View article: Comparing mortality from covid-19 to mortality due to overdose: A micromort analysis
Comparing mortality from covid-19 to mortality due to overdose: A micromort analysis Open
View article: Suicide reduction in Canada during the COVID-19 pandemic: lessons informing national prevention strategies for suicide reduction
Suicide reduction in Canada during the COVID-19 pandemic: lessons informing national prevention strategies for suicide reduction Open
Objective The objective of this research was to evaluate the impact of federal, public health and social support programs on national suicide rates in Canada. Design Cross-sectional study. Setting Canadian National Database (i.e., Statisti…
View article: Association Between Mood Disorders and Risk of COVID-19 Infection, Hospitalization, and Death
Association Between Mood Disorders and Risk of COVID-19 Infection, Hospitalization, and Death Open
The results of this systematic review and meta-analysis examining the association between preexisting mood disorders and COVID-19 outcomes suggest that individuals with preexisting mood disorders are at higher risk of COVID-19 hospitalizat…
View article: Screening Depressive Symptoms and Incident Major Depressive Disorder Among Chinese Community Residents Using a Mobile App–Based Integrated Mental Health Care Model: Cohort Study (Preprint)
Screening Depressive Symptoms and Incident Major Depressive Disorder Among Chinese Community Residents Using a Mobile App–Based Integrated Mental Health Care Model: Cohort Study (Preprint) Open
BACKGROUND Depression is associated with significant morbidity and human capital costs globally. Early screening for depressive symptoms and timely depressive disorder case identification and intervention may improve health outcomes and c…
View article: Government response moderates the mental health impact of COVID-19: A systematic review and meta-analysis of depression outcomes across countries
Government response moderates the mental health impact of COVID-19: A systematic review and meta-analysis of depression outcomes across countries Open
View article: Strategies to Prolong Ketamine’s Efficacy in Adults with Treatment-Resistant Depression
Strategies to Prolong Ketamine’s Efficacy in Adults with Treatment-Resistant Depression Open
Introduction: Ketamine treatment is capable of significant and rapid symptom improvement in adults with treatment-resistant depression (TRD). A limitation of ketamine treatment in TRD is the relatively short duration of time to relapse (e.…
View article: Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation
Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation Open
Replicated international studies have underscored the human and societal costs associated with major depressive disorder. Despite the proven efficacy of monoamine-based antidepressants in major depression, the majority of treated individua…
View article: Impact of SARS-CoV-2 Infection on Cognitive Function: A Systematic Review
Impact of SARS-CoV-2 Infection on Cognitive Function: A Systematic Review Open
The prevalence and etiology of COVID-19's impact on brain health and cognitive function is poorly characterized. With mounting reports of delirium, systemic inflammation, and evidence of neurotropism, a statement on cognitive impairment am…
View article: The impact of COVID-19 on subthreshold depressive symptoms: a longitudinal study
The impact of COVID-19 on subthreshold depressive symptoms: a longitudinal study Open
Aims The coronavirus disease 2019 (COVID-19) pandemic represents an unprecedented threat to mental health. Herein, we assessed the impact of COVID-19 on subthreshold depressive symptoms and identified potential mitigating factors. Methods …
View article: Development and implementation of guidelines for the management of depression: a systematic review
Development and implementation of guidelines for the management of depression: a systematic review Open
Globally, guideline implementation is inadequately planned, reported and measured. Narrowing disparities in the development and implementation of guidelines in low- and middle-income countries is a priority. Future guidelines should presen…
View article: Impact of COVID-19 pandemic on mental health in the general population: A systematic review
Impact of COVID-19 pandemic on mental health in the general population: A systematic review Open
View article: Recognition and Treatment of Cognitive Dysfunction in Major Depressive Disorder
Recognition and Treatment of Cognitive Dysfunction in Major Depressive Disorder Open
Major Depressive Disorder (MDD) is a prevalent, chronic, disabling, and multidimensional mental disorder. Cognitive dysfunction represents a core diagnostic and symptomatic criterion of MDD, and is a principal determinant of functional non…
View article: Predictors of Response to Ketamine in Treatment Resistant Major Depressive Disorder and Bipolar Disorder
Predictors of Response to Ketamine in Treatment Resistant Major Depressive Disorder and Bipolar Disorder Open
Objectives: Extant evidence indicates that ketamine exerts rapid antidepressant effects in treatment-resistant depressive (TRD) symptoms as a part of major depressive disorder (MDD) and bipolar disorder (BD). The identification of depresse…