Explanipedia

788 Local type 2 stromal-myeloid signalling axis drives progression and immunotherapy resistance of colorectal cancer metastasis Open

Jesse Boumelha, Frederika Rentzeperis, László Halász, Matthew D. Park, Raphal Mattiuz , et al. · 2025

Multiparametric cellular and spatial organization in cancer tissue lesions with a streamlined pipeline Open

Mark Buckup, Igor Figueiredo, Giorgio Ioannou, Sinem Ozbey, Rafael Cabal , et al. · 2025

Multiplex immunostaining analysis remains fragmented, underperforming and labour intensive despite tissue proteomic methodologies achieving ever-increasing marker complexity. Here we propose an open-source, user-guided automated pipeline t…

MARQO pipeline resolves multiparametric cellular and spatial organization in cancer tissue lesions Open

Mark Buckup, Igor Figueiredo, Giorgio Ioannou, Sinem Ozbey, Rafael Cabal , et al. · 2025

Multiplex immunostaining analysis remains fragmented, underperforming, and labor-intensive despite tissue proteomic methodologies achieving ever-increasing marker complexity. Here we propose an open-source, semi-supervised automated pipeli…

Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer Open

Raphaël Mattiuz, Jesse Boumelha, Pauline Hamon, Jessica Le Bérichel, Abishek Vaidya , et al. · 2024

Tertiary lymphoid structures (TLS) are organized immune cell aggregates that arise in chronic inflammatory conditions. In cancer, TLS are associated with better prognosis and enhanced response to immunotherapy, making these structures attr…

868 AXL restricts cholesterol mobilization, modulating dendritic cell maturation and the immune response to cancer Open

Meriem Belabed, Matthew D. Park, Cédric M. Blouin, Sreekumar Balan, Chang Moon , et al. · 2024

902 Hematopoietic aging promotes cancer by fueling IL-1α-driven emergency myelopoiesis Open

Matthew D. Park, Jessica Le Bérichel, Pauline Hamon, C. Matthias Wilk, Meriem Belabed , et al. · 2024

Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis Open

Matthew D. Park, Jessica Le Bérichel, Pauline Hamon, C. Matthias Wilk, Meriem Belabed , et al. · 2024

Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In this study, we establish that aging of the immune system, regardless of the age of the stroma and tumor, drives lung cancer progression. Hematop…

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors Open

Samarth Hegde, Bruno Giotti, Brian Y. Soong, László Halász, Jessica Le Bérichel , et al. · 2024

Monocyte–derived macrophages (mo-macs) drive immunosuppression in the tumor microenvironment (TME) and tumor-enhanced myelopoiesis in the bone marrow (BM) fuels these populations. Here, we performed paired transcriptome and chromatin analy…

AXL limits the mobilization of cholesterol to regulate dendritic cell maturation and the immunogenic response to cancer Open

Meriem Belabed, Matthew D. Park, Cédric M. Blouin, Sreekumar Balan, Chang Moon , et al. · 2023

Summary We previously found that uptake of cellular debris prompts conventional dendritic cells (cDCs) to undergo maturation. This transformation results in DCs entering the molecular state termed ‘mregDC’. In this state, mregDCs dampen th…

An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis Open

Nelson M. LaMarche, Samarth Hegde, Matthew D. Park, Bárbara Maier, Leanna Troncoso , et al. · 2023

Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders Open

C. Matthias Wilk, Flurin Cathomas, Orsolya Török, Jessica Le Bérichel, Matthew D. Park , et al. · 2023

650 Neoadjuvant ezabenlimab or pembrolizumab in combination with an anti-SIRPα antibody in resectable colorectal cancer Open

Natalie Lucas, Nicholas Venturini, Samarth Hegde, Raphaël Mattiuz, C. Hennequin , et al. · 2023

Background Although colorectal cancer (CRC) is traditionally considered to be immunologically inert, some subsets of colorectal cancer, particularly mismatch repair-deficient (MMRd) tumors, can be highly responsive to immune checkpoint blo…

Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration Open

C. Matthias Wilk, Flurin Cathomas, Orsolya Török, Jessica Le Bérichel, Matthew D. Park , et al. · 2023

Summary Neurodegenerative diseases (ND) are characterized by progressive loss of neuronal function. Mechanisms of ND pathogenesis are incompletely understood, hampering the development of effective therapies. Langerhans cell histiocytosis …

MERFISH data for "Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma" Open

Assaf Magen, Pauline Hamon, Nathalie Fiaschi, Brian Y. Soong, Matthew D. Park , et al. · 2023

MERFISH datasets for the publication "Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma" (Nature Medicine, 2023), generate…

MERFISH data for "Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma" Open

Assaf Magen, Pauline Hamon, Nathalie Fiaschi, Brian Y. Soong, Matthew D. Park , et al. · 2023

MERFISH datasets for the publication "Intratumoral dendritic cell–CD4⁺ T helper cell niches enable CD8⁺ T cell differentiation following PD-1 blockade in hepatocellular carcinoma" (Nature Medicine, 2023), generated in…

Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma Open

Assaf Magen, Pauline Hamon, Nathalie Fiaschi, Brian Y. Soong, Matthew D. Park , et al. · 2023

TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer Open

Matthew D. Park, Ivan Reyes-Torres, Jessica LeBérichel, Pauline Hamon, Nelson M. LaMarche , et al. · 2023

Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade Open

Assaf Magen, Pauline Hamon, Nathalie Fiaschi, Leanna Troncoso, Étienne Humblin , et al. · 2022

Here, we leveraged a large neoadjuvant PD-1 blockade trial in patients with hepatocellular carcinoma (HCC) to search for correlates of response to immune checkpoint blockade (ICB) within T cell-rich tumors. We show that ICB response correl…

Neoadjuvant cemiplimab for resectable hepatocellular carcinoma: a single-arm, open-label, phase 2 trial Open

Thomas U. Marron, Maria Isabel Fiel, Pauline Hamon, Nathalie Fiaschi, Edward Kim , et al. · 2022

Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification Open

Andrew M. Leader, John A. Grout, Bárbara Maier, Barzin Y. Nabet, Matthew D. Park , et al. · 2021

685 Characterization of molecular and spatial diversity of macrophages in hepatocellular carcinoma Open

Pauline Hamon, Assaf Magen, Joel Kim, Mark Buckup, Leanna Troncoso , et al. · 2021

Background Hepatocellular carcinoma (HCC) has a dismal prognosis, and though checkpoint blocking antibodies have significantly improved patient outcome, many patients remain left out, highlighting the need to identify additional immune tar…

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells Open

María Casanova-Acebes, Erica Dalla, Andrew M. Leader, Jessica LeBérichel, Jovan Nikolić , et al. · 2021

TREM2 Sensing of Tumor Cell Efferocytosis Promotes a Macrophage Molecular State that Limits NK Cell Antitumor Immunity Open

Ivan Reyes-Torres, Matthew Park, Assaf Magen, Pauline Hamon, Alfonso R. Sánchez-Paulete , et al. · 2021

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