Leanne E. Fisher
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View article: Molecular Biointerface Characterisation For An Implanted Medical Device Using Cryogenic Orbitrap Secondary Ion Mass Spectrometry (Cryo-OrbiSIMS)
Molecular Biointerface Characterisation For An Implanted Medical Device Using Cryogenic Orbitrap Secondary Ion Mass Spectrometry (Cryo-OrbiSIMS) Open
Implanted medical devices often fail due to foreign body reaction (FBR), a process still not fully understood. This study examines silicone rubber poly(dimethyl siloxane) catheters implanted in mice for 1 and 28 days. Cryo-OrbiSIMS was use…
View article: Spatially Resolved Molecular Analysis of Host Response to Medical Device Implantation Using the 3D OrbiSIMS Highlights a Critical Role for Lipids
Spatially Resolved Molecular Analysis of Host Response to Medical Device Implantation Using the 3D OrbiSIMS Highlights a Critical Role for Lipids Open
A key goal for implanted medical devices is that they do not elicit a detrimental immune response. Macrophages play critical roles in the modulation of the host immune response and are the cells responsible for persistent inflammatory reac…
View article: Inflammatory Network of Liver Fibrosis and How It Can Be Targeted Therapeutically
Inflammatory Network of Liver Fibrosis and How It Can Be Targeted Therapeutically Open
Liver fibrosis is a complex, dynamic process associated with a broad spectrum of chronic liver diseases and acute liver failure, characterised by the dysregulated intrahepatic production of extracellular matrix proteins replacing functiona…
View article: Co-assembling living material as an in vitro lung epithelial infection model
Co-assembling living material as an in vitro lung epithelial infection model Open
View article: Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS highlights a critical role for lipids
Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS highlights a critical role for lipids Open
A key goal for implanted medical devices is that they do not elicit a detrimental immune response. Macrophages play critical roles in modulation of the host immune response and are the major cells responsible for persistent inflammatory re…
View article: Label-free Chemical Characterization of Polarized Immune Cells in vitro and Host Response to Implanted Bio-instructive Polymers in vivo Using 3D OrbiSIMS
Label-free Chemical Characterization of Polarized Immune Cells in vitro and Host Response to Implanted Bio-instructive Polymers in vivo Using 3D OrbiSIMS Open
The Three-dimensional OrbiTrap Secondary Ion Mass Spectrometry (3D OrbiSIMS) is a secondary ion mass spectrometry instrument, a combination of a Time of Flight (ToF) instrument with an Orbitrap analyzer. The 3D OrbiSIMS technique is a powe…
View article: Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing
Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing Open
Wound healing is a complex biological process involving close crosstalk between various cell types. Dysregulation in any of these processes, such as in diabetic wounds, results in chronic nonhealing wounds. Fibroblasts are a critical cell …
View article: Immune-instructive materials as new tools for immunotherapy
Immune-instructive materials as new tools for immunotherapy Open
View article: Mitigating the foreign body response through ‘immune-instructive’ biomaterials
Mitigating the foreign body response through ‘immune-instructive’ biomaterials Open
View article: Immune-instructive materials and surfaces for medical applications
Immune-instructive materials and surfaces for medical applications Open
View article: Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo
Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo Open
© 2020 The Authors This study explores the hypothesis that simple polymer chemistries can be used to modulate the phenotype of human immune cells. Unbiased high-throughput screening of a large library of polymer chemistries is undertaken, …
View article: Bioinspired bactericidal surfaces with polymer nanocone arrays
Bioinspired bactericidal surfaces with polymer nanocone arrays Open
View article: Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands
Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands Open
View article: Bactericidal activity of biomimetic diamond nanocone surfaces
Bactericidal activity of biomimetic diamond nanocone surfaces Open
The formation of biofilms on implant surfaces and the subsequent development of medical device-associated infections are difficult to resolve and can cause considerable morbidity to the patient. Over the past decade, there has been growing…
View article: Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity
Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity Open