Stephanie L. Johnson
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View article: ATP hydrolysis coordinates the activities of two motors in a dimeric chromatin remodeling enzyme
ATP hydrolysis coordinates the activities of two motors in a dimeric chromatin remodeling enzyme Open
ATP-dependent chromatin remodelers are essential enzymes that restructure eukaryotic genomes to enable all DNA-based processes. The diversity and complexity of these processes are matched by the complexity of the enzymes that carry them ou…
View article: Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome
Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome Open
The SNF2h remodeler slides nucleosomes most efficiently as a dimer, yet how the two protomers avoid a tug-of-war is unclear. Furthermore, SNF2h couples histone octamer deformation to nucleosome sliding, but the underlying structural basis …
View article: Ion counting demonstrates a high electrostatic field generated by the nucleosome
Ion counting demonstrates a high electrostatic field generated by the nucleosome Open
In eukaryotes, a first step towards the nuclear DNA compaction process is the formation of a nucleosome, which is comprised of negatively charged DNA wrapped around a positively charged histone protein octamer. Often, it is assumed that th…
View article: Electron cryo-microscopy structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome
Electron cryo-microscopy structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome Open
The SNF2h remodeler slides nucleosomes most efficiently as a dimer, yet how the two protomers avoid a tug-of-war is unclear. Furthermore, SNF2h couples histone octamer deformation to nucleosome sliding, but the underlying structural basis …
View article: Ion counting demonstrates a high electrostatic potential of the nucleosome
Ion counting demonstrates a high electrostatic potential of the nucleosome Open
The fundamental unit of chromatin is the nucleosome, which comprises of DNA wrapped around a histone protein octamer. The association of positively charged histone proteins with negatively charged DNA is intuitively thought to attenuate th…
View article: Cryo-EM structure of singly-bound SNF2h-nucleosome complex with SNF2h bound at SHL-2
Cryo-EM structure of singly-bound SNF2h-nucleosome complex with SNF2h bound at SHL-2 Open
The SNF2h remodeler slides nucleosomes most efficiently as a dimer, yet how the two protomers avoid a tug-of-war is unclear. Furthermore, SNF2h couples histone octamer deformation to nucleosome sliding, but the underlying structural basis …
View article: Up from Poverty: A Narrative Non-Fiction Study of Three Female Superintendents from Poverty
Up from Poverty: A Narrative Non-Fiction Study of Three Female Superintendents from Poverty Open
This study focused on three female superintendents from poverty and how they elevated out of poverty to become successful superintendents in their school districts and help students living in poverty.
View article: The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h
The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h Open
ISWI family chromatin remodeling motors use sophisticated autoinhibition mechanisms to control nucleosome sliding. Yet how the different autoinhibitory domains are regulated is not well understood. Here we show that an acidic patch formed …
View article: Author response: The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h
Author response: The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract ISWI family chromatin remodel…
View article: Mechanisms of ATP-Dependent Chromatin Remodeling Motors
Mechanisms of ATP-Dependent Chromatin Remodeling Motors Open
Chromatin remodeling motors play essential roles in all DNA-based processes. These motors catalyze diverse outcomes ranging from sliding the smallest units of chromatin, known as nucleosomes, to completely disassembling chromatin. The broa…