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View article: Correction: An in vitro method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen Cryptococcus gattii
Correction: An in vitro method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen Cryptococcus gattii Open
[This corrects the article DOI: 10.1371/journal.ppat.1010321.].
View article: An in vitro method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen Cryptococcus gattii
An in vitro method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen Cryptococcus gattii Open
Cryptococcosis is a potentially lethal fungal infection of humans caused by organisms within the Cryptococcus neoformans/gattii species complex. Whilst C . neoformans is a relatively common pathogen of immunocompromised individuals, C . ga…
View article: An <i>in vitro</i> method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen <i>Cryptococcus gattii</i>
An <i>in vitro</i> method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen <i>Cryptococcus gattii</i> Open
Cryptococcosis is a potentially lethal fungal infection of humans caused by organisms within the Cryptococcus neoformans/gattii species complex. Whilst C. neoformans is a relatively common pathogen of immunocompromised individuals, C. gatt…
View article: Viral infection triggers interferon-induced expulsion of live Cryptococcus neoformans by macrophages
Viral infection triggers interferon-induced expulsion of live Cryptococcus neoformans by macrophages Open
Cryptococcus neoformans is an opportunistic human pathogen, which causes serious disease in immunocompromised hosts. Infection with this pathogen is particularly relevant in HIV+ patients, where it leads to around 200,000 deaths per annum.…
View article: Viral infection enhances vomocytosis of intracellular fungi via Type I interferons
Viral infection enhances vomocytosis of intracellular fungi via Type I interferons Open
Cryptococcus neoformans is an opportunistic human pathogen, which causes serious disease in immunocompromised hosts. Infection with this pathogen is particularly relevant in HIV+ patients, where it leads to around 200,000 deaths per annum …
View article: The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis
The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis Open
Fungal cells change shape in response to environmental stimuli, and these morphogenic transitions drive pathogenesis and niche adaptation. For example, dimorphic fungi switch between yeast and hyphae in response to changing temperature. Th…
View article: Characterizing the Mechanisms of Nonopsonic Uptake of Cryptococci by Macrophages
Characterizing the Mechanisms of Nonopsonic Uptake of Cryptococci by Macrophages Open
The pathogenic fungus Cryptococcus enters the human host via inhalation into the lung and is able to reside in a niche environment that is serum- (opsonin) limiting. Little is known about the mechanism by which nonopsonic phagocytosis occu…
View article: Quantifying donor-to-donor variation in macrophage responses to the human fungal pathogen Cryptococcus neoformans
Quantifying donor-to-donor variation in macrophage responses to the human fungal pathogen Cryptococcus neoformans Open
Cryptococcosis remains the leading cause of fungal meningitis worldwide, caused primarily by the pathogen Cryptococcus neoformans. Symptomatic cryptococcal infections typically affect immunocompromised patients. However, environmental expo…
View article: Correction: Engineering microbial physiology with synthetic polymers: cationic polymers induce biofilm formation in<i>Vibrio cholerae</i>and downregulate the expression of virulence genes
Correction: Engineering microbial physiology with synthetic polymers: cationic polymers induce biofilm formation in<i>Vibrio cholerae</i>and downregulate the expression of virulence genes Open
Correction for ‘Engineering microbial physiology with synthetic polymers: cationic polymers induce biofilm formation inVibrio choleraeand downregulate the expression of virulence genes’ by Nicolas Perez-Sotoet al.,Chem. Sci., 2017,8, 5291–…
View article: Cryptococcus–Epithelial Interactions
Cryptococcus–Epithelial Interactions Open
The fungal pathogen, Cryptococcus neoformans, causes devastating levels of morbidity and mortality. Infections with this fungus tend to be predominantly in immunocompromised individuals, such as those with HIV. Infections initiate with inh…
View article: The<i>Cryptococcus neoformans</i>Titan cell is an inducible and regulated morphotype underlying pathogenesis
The<i>Cryptococcus neoformans</i>Titan cell is an inducible and regulated morphotype underlying pathogenesis Open
Fungi undergo changes in cell shape in response to environmental stimuli that drive pathogenesis and niche adaptation, such as the yeast-to-hyphal transition of dimorphic fungi in response to changing temperature. The basidiomycete Cryptoc…
View article: Engineering microbial physiology with synthetic polymers: cationic polymers induce biofilm formation in <i>Vibrio cholerae</i> and downregulate the expression of virulence genes
Engineering microbial physiology with synthetic polymers: cationic polymers induce biofilm formation in <i>Vibrio cholerae</i> and downregulate the expression of virulence genes Open
Here we report the first application of non-bactericidal synthetic polymers to modulate the physiology of a bacterial pathogen.
View article: Engineering Microbial Physiology with Synthetic Polymers: Cationic Polymers Induce Biofilm Formation in<i>Vibrio cholerae</i>and Downregulate the Expression of Virulence Genes
Engineering Microbial Physiology with Synthetic Polymers: Cationic Polymers Induce Biofilm Formation in<i>Vibrio cholerae</i>and Downregulate the Expression of Virulence Genes Open
Here we report the first application of non-bactericidal synthetic polymers to modulate the physiology of a bacterial pathogen. Poly( N -[3-(dimethylamino)propyl]methacrylamide) ( P1 ) and poly( N -(3-aminopropyl) methacrylamide) ( P2 ), c…