Léanne Strauss
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APEX-based proximity labeling in Plasmodium identifies a membrane protein with dual functions during mosquito infection Open
Transmission of the malaria parasite Plasmodium to mosquitoes necessitates gamete egress from red blood cells to allow zygote formation and ookinete motility to enable penetration of the midgut epithelium. Both processes are dependent on t…
View article: Caging of membrane-to-cortex attachment proteins can trigger cellular symmetry breaking
Caging of membrane-to-cortex attachment proteins can trigger cellular symmetry breaking Open
SUMMARY To migrate, divide, and change shape, cells must regulate the mechanics of their periphery. The cell surface is a complex structure that consists of a thin, contractile cortical actin network tethered to the plasma membrane by spec…
View article: The distance between the plasma membrane and the actomyosin cortex acts as a nanogate to control cell surface mechanics
The distance between the plasma membrane and the actomyosin cortex acts as a nanogate to control cell surface mechanics Open
Animal cell shape changes are controlled by the actomyosin cortex, a peripheral actin network tethered to the plasma membrane by membrane-to-cortex attachment (MCA) proteins. Previous studies have focused on how myosin motors or actin turn…
APEX-based proximity labeling in<i>Plasmodium</i>identifies a membrane protein with dual functions during mosquito infection Open
Transmission of the malaria parasite Plasmodium to mosquitoes necessitates gamete egress from red blood cells to allow zygote formation and ookinete motility to enable penetration of the midgut epithelium. Both processes are dependent on t…
Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP Open
Inserted (I) domains function as ligand-binding domains in adhesins that support cell adhesion and migration in many eukaryotic phyla. These adhesins include integrin αβ heterodimers in metazoans and single subunit transmembrane proteins i…
Author response: Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Inserted (I) domains function…
A function of profilin in force generation during malaria parasite motility independent of actin binding Open
During transmission of malaria-causing parasites from mosquito to mammal, Plasmodium sporozoites migrate at high speed within the skin to access the bloodstream and infect the liver. This unusual gliding motility is based on retrograde flo…
Cationic charge and polyspecificity of an integrin domain regulates infectivity of malaria parasites Open
Cell-cell and cell-substrate adhesion is critical for many functions in life. In eukaryotes, I-domains mediate functions as divergent as tissue traversal by malaria-causing Plasmodium parasites as well as cell adhesion and migration by hum…
A unique profilin-actin interface is important for malaria parasite motility Open
Profilinis anactinmonomerbindingproteinthatprovidesATP-actinforincorporationintoactinfilaments.In contrastto highereukaryoticcellswiththeirlargefilamentousactinstruc-tures,apicomplexanparasitestypicallycontainonlyshortandhighlydynamicmicro…