Lee E. Moore
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View article: Supplementary Materials from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer
Supplementary Materials from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer Open
Supplementary Materials from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer
View article: Perspectives on This Article from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer
Perspectives on This Article from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer Open
Perspectives on This Article from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer
View article: Data from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer
Data from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer Open
A panel of biomarkers may improve predictive performance over individual markers. Although many biomarker panels have been described for ovarian cancer, few studies used prediagnostic samples to assess the potential of the panels for early…
View article: Perspectives on This Article from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer
Perspectives on This Article from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer Open
Perspectives on This Article from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer
View article: Supplementary Materials from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer
Supplementary Materials from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer Open
Supplementary Materials from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer
View article: Data from DNA Methylation Levels at Chromosome 8q24 in Peripheral Blood Are Associated with 8q24 Cancer Susceptibility Loci
Data from DNA Methylation Levels at Chromosome 8q24 in Peripheral Blood Are Associated with 8q24 Cancer Susceptibility Loci Open
Chromosome 8q24 has emerged as an important region for genetic susceptibility to various cancers, but little is known about the contribution of DNA methylation at 8q24. To evaluate variability in DNA methylation levels at 8q24 and the rela…
View article: Data from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer
Data from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer Open
A panel of biomarkers may improve predictive performance over individual markers. Although many biomarker panels have been described for ovarian cancer, few studies used prediagnostic samples to assess the potential of the panels for early…
View article: Data from Can Lactase Persistence Genotype Be Used to Reassess the Relationship between Renal Cell Carcinoma and Milk Drinking? Potentials and Problems in the Application of Mendelian Randomization
Data from Can Lactase Persistence Genotype Be Used to Reassess the Relationship between Renal Cell Carcinoma and Milk Drinking? Potentials and Problems in the Application of Mendelian Randomization Open
Background: Increased risk of renal cell carcinoma (RCC) with milk consumption has been reported from observational studies. Whether this represents a causal association or is a result of confounding or bias is unclear. We assessed the pot…
View article: Supplementary Data from Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors
Supplementary Data from Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors Open
Supplementary Data from Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors
View article: Supplementary Data from Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors
Supplementary Data from Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors Open
Supplementary Data from Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors
View article: Supplementary Table 2 from Drinking Water Arsenic in Northern Chile: High Cancer Risks 40 Years after Exposure Cessation
Supplementary Table 2 from Drinking Water Arsenic in Northern Chile: High Cancer Risks 40 Years after Exposure Cessation Open
PDF file - 31K - Bladder and lung cancer odds ratios including only cases with histologic confirmation, in non-proxy subjects, and in males and females comparing subjects in the upper to lower quartiles of average lifetime arsenic concentr…
View article: Supplementary from Targeted Deep Sequencing of Bladder Tumors Reveals Novel Associations between Cancer Gene Mutations and Mutational Signatures with Major Risk Factors
Supplementary from Targeted Deep Sequencing of Bladder Tumors Reveals Novel Associations between Cancer Gene Mutations and Mutational Signatures with Major Risk Factors Open
Supplementary
View article: Data from Can Lactase Persistence Genotype Be Used to Reassess the Relationship between Renal Cell Carcinoma and Milk Drinking? Potentials and Problems in the Application of Mendelian Randomization
Data from Can Lactase Persistence Genotype Be Used to Reassess the Relationship between Renal Cell Carcinoma and Milk Drinking? Potentials and Problems in the Application of Mendelian Randomization Open
Background: Increased risk of renal cell carcinoma (RCC) with milk consumption has been reported from observational studies. Whether this represents a causal association or is a result of confounding or bias is unclear. We assessed the pot…
View article: Supplementary Table 2 from Drinking Water Arsenic in Northern Chile: High Cancer Risks 40 Years after Exposure Cessation
Supplementary Table 2 from Drinking Water Arsenic in Northern Chile: High Cancer Risks 40 Years after Exposure Cessation Open
PDF file - 31K - Bladder and lung cancer odds ratios including only cases with histologic confirmation, in non-proxy subjects, and in males and females comparing subjects in the upper to lower quartiles of average lifetime arsenic concentr…
View article: Data from Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors
Data from Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors Open
Purpose: To provide a comprehensive, thorough analysis of somatic mutation and promoter hypermethylation of the von Hippel-Lindau (VHL) gene in the cancer genome, unique to clear cell renal cancer (ccRCC). Identify relationships between th…
View article: Data from Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors
Data from Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors Open
Purpose: To provide a comprehensive, thorough analysis of somatic mutation and promoter hypermethylation of the von Hippel-Lindau (VHL) gene in the cancer genome, unique to clear cell renal cancer (ccRCC). Identify relationships between th…
View article: Supplementary from Targeted Deep Sequencing of Bladder Tumors Reveals Novel Associations between Cancer Gene Mutations and Mutational Signatures with Major Risk Factors
Supplementary from Targeted Deep Sequencing of Bladder Tumors Reveals Novel Associations between Cancer Gene Mutations and Mutational Signatures with Major Risk Factors Open
Supplementary
View article: Data from Increased Lung and Bladder Cancer Incidence in Adults after <i>In Utero</i> and Early-Life Arsenic Exposure
Data from Increased Lung and Bladder Cancer Incidence in Adults after <i>In Utero</i> and Early-Life Arsenic Exposure Open
Background: From 1958 to 1970, >100,000 people in northern Chile were exposed to a well-documented, distinct period of high drinking water arsenic concentrations. We previously reported ecological evidence suggesting that early-life exposu…
View article: Supplementary Methods, Tables 1 - 9 from Concurrent Alterations in <i>TERT</i>, <i>KDM6A</i>, and the BRCA Pathway in Bladder Cancer
Supplementary Methods, Tables 1 - 9 from Concurrent Alterations in <i>TERT</i>, <i>KDM6A</i>, and the BRCA Pathway in Bladder Cancer Open
Supplementary Table S1 presents the clinical characteristics of patients and tumors analyzed in the study. Supplementary Table S2 contains the details about next generation sequencing of the tumor exomes, mapped reads, target depth, and ta…
View article: Data from Targeted Deep Sequencing of Bladder Tumors Reveals Novel Associations between Cancer Gene Mutations and Mutational Signatures with Major Risk Factors
Data from Targeted Deep Sequencing of Bladder Tumors Reveals Novel Associations between Cancer Gene Mutations and Mutational Signatures with Major Risk Factors Open
Purpose:Exome- and whole-genome sequencing of muscle-invasive bladder cancer has revealed important insights into the molecular landscape; however, there are few studies of non–muscle-invasive bladder cancer with detailed risk factor infor…
View article: Supplementary Table 1 from Can Lactase Persistence Genotype Be Used to Reassess the Relationship between Renal Cell Carcinoma and Milk Drinking? Potentials and Problems in the Application of Mendelian Randomization
Supplementary Table 1 from Can Lactase Persistence Genotype Be Used to Reassess the Relationship between Renal Cell Carcinoma and Milk Drinking? Potentials and Problems in the Application of Mendelian Randomization Open
Supplementary Table 1 from Can Lactase Persistence Genotype Be Used to Reassess the Relationship between Renal Cell Carcinoma and Milk Drinking? Potentials and Problems in the Application of Mendelian Randomization
View article: Data from Increased Lung and Bladder Cancer Incidence in Adults after <i>In Utero</i> and Early-Life Arsenic Exposure
Data from Increased Lung and Bladder Cancer Incidence in Adults after <i>In Utero</i> and Early-Life Arsenic Exposure Open
Background: From 1958 to 1970, >100,000 people in northern Chile were exposed to a well-documented, distinct period of high drinking water arsenic concentrations. We previously reported ecological evidence suggesting that early-life exposu…
View article: Supplementary Tables 1 through 3 from Increased Lung and Bladder Cancer Incidence in Adults after <i>In Utero</i> and Early-Life Arsenic Exposure
Supplementary Tables 1 through 3 from Increased Lung and Bladder Cancer Incidence in Adults after <i>In Utero</i> and Early-Life Arsenic Exposure Open
PDF - 115K, Table S1. Comparison of subjects included in this analysis to subjects excluded because they had high exposures both in early life and adulthood. Table S2. Comparison of residences of the Chile case control study controls at th…
View article: Supplementary Table 1 from Can Lactase Persistence Genotype Be Used to Reassess the Relationship between Renal Cell Carcinoma and Milk Drinking? Potentials and Problems in the Application of Mendelian Randomization
Supplementary Table 1 from Can Lactase Persistence Genotype Be Used to Reassess the Relationship between Renal Cell Carcinoma and Milk Drinking? Potentials and Problems in the Application of Mendelian Randomization Open
Supplementary Table 1 from Can Lactase Persistence Genotype Be Used to Reassess the Relationship between Renal Cell Carcinoma and Milk Drinking? Potentials and Problems in the Application of Mendelian Randomization
View article: Data from Targeted Deep Sequencing of Bladder Tumors Reveals Novel Associations between Cancer Gene Mutations and Mutational Signatures with Major Risk Factors
Data from Targeted Deep Sequencing of Bladder Tumors Reveals Novel Associations between Cancer Gene Mutations and Mutational Signatures with Major Risk Factors Open
Purpose:Exome- and whole-genome sequencing of muscle-invasive bladder cancer has revealed important insights into the molecular landscape; however, there are few studies of non–muscle-invasive bladder cancer with detailed risk factor infor…
View article: Supplementary Tables 1 through 3 from Increased Lung and Bladder Cancer Incidence in Adults after <i>In Utero</i> and Early-Life Arsenic Exposure
Supplementary Tables 1 through 3 from Increased Lung and Bladder Cancer Incidence in Adults after <i>In Utero</i> and Early-Life Arsenic Exposure Open
PDF - 115K, Table S1. Comparison of subjects included in this analysis to subjects excluded because they had high exposures both in early life and adulthood. Table S2. Comparison of residences of the Chile case control study controls at th…
View article: Supplementary Materials, Figures 1 - 3, Tables 1 - 4, 6 - 8 from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease
Supplementary Materials, Figures 1 - 3, Tables 1 - 4, 6 - 8 from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease Open
Supplementary Figure 1: Electrophoretic mobility shift assays (EMSA) for CCNE1 SNPs rs8102137 and rs7257330. Supplementary Figure 2: Alignment of cyclin E protein isoforms - WT1, WT2 and ES and ET. Supplementary Figure 3: Functional analys…
View article: Supplementary Table 2 from Apolipoprotein E/C1 Locus Variants Modify Renal Cell Carcinoma Risk
Supplementary Table 2 from Apolipoprotein E/C1 Locus Variants Modify Renal Cell Carcinoma Risk Open
Supplementary Table 2 from Apolipoprotein E/C1 Locus Variants Modify Renal Cell Carcinoma Risk
View article: Data from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease
Data from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease Open
A genome-wide association study (GWAS) of bladder cancer identified a genetic marker rs8102137 within the 19q12 region as a novel susceptibility variant. This marker is located upstream of the CCNE1 gene, which encodes cyclin E, a cell-cyc…
View article: Supplementary Figure 1 from Apolipoprotein E/C1 Locus Variants Modify Renal Cell Carcinoma Risk
Supplementary Figure 1 from Apolipoprotein E/C1 Locus Variants Modify Renal Cell Carcinoma Risk Open
Supplementary Figure 1 from Apolipoprotein E/C1 Locus Variants Modify Renal Cell Carcinoma Risk