Lee Edsall
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View article: Author response: Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity
Author response: Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity Open
View article: Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity
Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity Open
Human cytomegalovirus (HCMV) infects up to 80% of the world’s population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions a…
View article: Author response: Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity
Author response: Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity Open
View article: Genome-wide discovery of multiple sclerosis genetic risk variant allelic regulatory activity
Genome-wide discovery of multiple sclerosis genetic risk variant allelic regulatory activity Open
Multiple sclerosis is an immune-mediated demyelinating disease of the central nervous system with a complex etiology involving environmental and genetic factors. Numerous genetic risk loci for multiple sclerosis have been nominated through…
View article: Massively parallel analysis of genotype-dependent enhancer activity among atopic dermatitis genetic risk variants
Massively parallel analysis of genotype-dependent enhancer activity among atopic dermatitis genetic risk variants Open
Our systematic, genome-scale approach implicates causal genotype-dependent gene regulatory mechanisms for most AD risk loci, providing a unique resource for the discovery of the genetic mechanisms underlying this disease.
View article: Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity
Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity Open
Human cytomegalovirus (HCMV) infects up to 80% of the world’s population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions a…
View article: Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity
Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity Open
Human cytomegalovirus (HCMV) infects up to 80% of the world’s population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions a…
View article: Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity
Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity Open
Summary Human cytomegalovirus (HCMV) infects up to 80% of the world’s population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic r…
View article: Shared and distinct interactions of type 1 and type 2 Epstein-Barr Nuclear Antigen 2 with the human genome
Shared and distinct interactions of type 1 and type 2 Epstein-Barr Nuclear Antigen 2 with the human genome Open
Background There are two major genetic types of Epstein-Barr Virus (EBV): type 1 (EBV-1) and type 2 (EBV-2). EBV functions by manipulating gene expression in host B cells, using virus-encoded gene regulatory proteins including Epstein-Barr…
View article: Systematic identification of genotype-dependent enhancer variants in eosinophilic esophagitis
Systematic identification of genotype-dependent enhancer variants in eosinophilic esophagitis Open
View article: Massively Parallel Analysis of Genotype-Dependent Enhancer Activity Among Atopic Dermatitis Genetic Risk Variants
Massively Parallel Analysis of Genotype-Dependent Enhancer Activity Among Atopic Dermatitis Genetic Risk Variants Open
View article: Epigenetic and Transcriptional Dysregulation in CD4+ T cells of Patients with Atopic Dermatitis
Epigenetic and Transcriptional Dysregulation in CD4+ T cells of Patients with Atopic Dermatitis Open
Atopic dermatitis (AD) is one of the most common skin disorders in children. Disease etiology involves genetic and environmental factors, with the 29 independent AD risk loci enriched for risk allele-dependent gene expression in the skin a…
View article: Epstein-Barr virus nuclear antigen 2 (EBNA2) extensively rewires the human chromatin landscape at autoimmune risk loci
Epstein-Barr virus nuclear antigen 2 (EBNA2) extensively rewires the human chromatin landscape at autoimmune risk loci Open
The interplay between environmental and genetic factors plays a key role in the development of many autoimmune diseases. In particular, the Epstein-Barr virus (EBV) is an established contributor to multiple sclerosis, lupus, and other diso…
View article: Evaluating chromatin accessibility differences across multiple primate species using a joint modelling approach
Evaluating chromatin accessibility differences across multiple primate species using a joint modelling approach Open
Changes in transcriptional regulation are thought to be a major contributor to the evolution of phenotypic traits, but the contribution of changes in chromatin accessibility to the evolution of gene expression remains almost entirely unkno…
View article: Incomplete MyoD-induced transdifferentiation is associated with chromatin remodeling deficiencies
Incomplete MyoD-induced transdifferentiation is associated with chromatin remodeling deficiencies Open
Our current understanding of cellular transdifferentiation systems is limited. It is oftentimes unknown, at a genome-wide scale, how much transdifferentiated cells differ quantitatively from both the starting cells and the target cells. Fo…
View article: MP90-06 FULL EXOME SEQUENCING, COPY NUMBER VARIATION AND TRANSCRIPTOME ANALYSES REVEALS DIVERSITY AND MUTATIONAL EVOLUTION IN A LONGITUDINAL SERIES OF SURGICAL PROSTATE CANCER BONE METASTASES FROM A PATIENT WITH PROGRESSIVELY THERAPY-RESISTANT CANCER.
MP90-06 FULL EXOME SEQUENCING, COPY NUMBER VARIATION AND TRANSCRIPTOME ANALYSES REVEALS DIVERSITY AND MUTATIONAL EVOLUTION IN A LONGITUDINAL SERIES OF SURGICAL PROSTATE CANCER BONE METASTASES FROM A PATIENT WITH PROGRESSIVELY THERAPY-RESISTANT CANCER. Open
You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology IV1 Apr 2016MP90-06 FULL EXOME SEQUENCING, COPY NUMBER VARIATION AND TRANSCRIPTOME ANALYSES REVEALS DIVERSITY AND MUTATIONAL EVOLUTION IN A LONGITUDINAL SER…
View article: Integrative analysis of haplotype-resolved epigenomes across human tissues
Integrative analysis of haplotype-resolved epigenomes across human tissues Open
View article: DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions
DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions Open
FOXP3 is a lineage-specific transcription factor that is required for regulatory T cell development and function. In this study, we determined the crystal structure of the FOXP3 forkhead domain bound to DNA. The structure reveals that FOXP…