Lee Hilliard
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View article: Effect of Anticoagulant Therapy for 6 Weeks vs 3 Months on Recurrence and Bleeding Events in Patients Younger Than 21 Years of Age With Provoked Venous Thromboembolism
Effect of Anticoagulant Therapy for 6 Weeks vs 3 Months on Recurrence and Bleeding Events in Patients Younger Than 21 Years of Age With Provoked Venous Thromboembolism Open
ClinicalTrials.gov Identifier: NCT00687882.
View article: Impact of Telehealth Visit and Socioeconomic Status (SES) on Hydroxyurea Response in Sickle Cell Anemia
Impact of Telehealth Visit and Socioeconomic Status (SES) on Hydroxyurea Response in Sickle Cell Anemia Open
Background It is important to ensure access to hydroxyurea (HU) for patients with sickle cell anemia (SCA) living in rural areas without easy access to experts in sickle cell management. The UAB Pediatric Sickle Cell program’s satellite cl…
View article: Transcranial Doppler Screening in a Current Cohort of Children With Sickle Cell Anemia: Results From the DISPLACE Study
Transcranial Doppler Screening in a Current Cohort of Children With Sickle Cell Anemia: Results From the DISPLACE Study Open
Stroke prevention guidelines for sickle cell anemia (SCA) recommend transcranial Doppler (TCD) screening to identify children at stroke risk; however, TCD screening implementation remains poor. This report describes results from Part 1 of …
View article: Hyperuricemia and abnormal nocturnal dipping impact glomerular filtration rate in patients with sickle cell anemia
Hyperuricemia and abnormal nocturnal dipping impact glomerular filtration rate in patients with sickle cell anemia Open
Patients with sickle cell anemia (SCA) are at increased risk for developing chronic kidney disease (CKD), and progression to end-stage renal disease is associated with increased morbidity and mortality. Identifying modifiable risk factors …
View article: Hyperfiltration during early childhood precedes albuminuria in pediatric sickle cell nephropathy
Hyperfiltration during early childhood precedes albuminuria in pediatric sickle cell nephropathy Open
Background In patients with diabetes mellitus, hyperfiltration precedes the development of albuminuria. Pediatric sickle cell anemia (SCA) patients have a high prevalence of hyperfiltration and albuminuria during early childhood and adoles…
View article: Double-blind, randomized, multicenter phase 2 study of SC411 in children with sickle cell disease (SCOT trial)
Double-blind, randomized, multicenter phase 2 study of SC411 in children with sickle cell disease (SCOT trial) Open
Key Points SC411 increases DHA in blood cell membranes and reduces home-managed SCD pain crisis and analgesic and opioid use at home to treat SCD pain. The rate of sickle cell crisis was 53% lower for the pooled active groups vs placebo.
View article: The phenotypic spectrum of germline <i>YARS2</i> variants: from isolated sideroblastic anemia to mitochondrial myopathy, lactic acidosis and sideroblastic anemia 2
The phenotypic spectrum of germline <i>YARS2</i> variants: from isolated sideroblastic anemia to mitochondrial myopathy, lactic acidosis and sideroblastic anemia 2 Open
YARS2 variants have previously been described in patients with myopathy, lactic acidosis and sideroblastic anemia 2 (MLASA2). YARS2 encodes the mitochondrial tyrosyl-tRNA synthetase, which is responsible for conjugating tyrosine to its cog…
View article: Outcomes in Mild to Moderate Isolated Thrombocytopenia
Outcomes in Mild to Moderate Isolated Thrombocytopenia Open
OBJECTIVES: Incidental isolated mild to moderate thrombocytopenia is a frequent laboratory finding prompting a referral to pediatric hematology-oncology. We tested the hypothesis that patients with isolated asymptomatic mild thrombocytopen…
View article: Morphologic features of normoblasts in a case of myopathy, lactic acidosis, and sideroblastic anemia
Morphologic features of normoblasts in a case of myopathy, lactic acidosis, and sideroblastic anemia Open
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A 17-year-old girl with a history of hypoplastic anemia that required transfusions twice resolved during infancy presented with fatigue and muscle pain with exertion. A complete blood count revealed normocytic anemia (hemogl…
View article: Severe anemia early in life as a risk factor for sickle-cell kidney disease
Severe anemia early in life as a risk factor for sickle-cell kidney disease Open
To the editor:
Patients with sickle-cell disease (SCD) are at high risk for morbidity and mortality from SCD nephropathy.[1][1],[2][2] During adolescence, 20% to 35% of patients develop microalbuminuria (MiA; 30-300 mg/g Cr) classified as…
View article: Maintaining High Level of Care at Satellite Sickle Cell Clinics
Maintaining High Level of Care at Satellite Sickle Cell Clinics Open
Traveling to and from university-based clinics is a major health care barrier for children with sickle cell disease in Alabama. To reduce this barrier, the University of Alabama at Birmingham (UAB) developed satellite clinics. This study s…
View article: Hydroxyurea decreases hospitalizations in pediatric patients with Hb SC and Hb SB+ thalassemia
Hydroxyurea decreases hospitalizations in pediatric patients with Hb SC and Hb SB+ thalassemia Open
This cohort of patients with Hb SC and SB+ thalassemia provides additional support for using HU in patients with recurrent hospitalizations for pain. A large randomized multicenter trial of HU to reduce pain admissions should be conducted …
View article: Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the <scp>TW</scp>i<scp>TCH</scp> trial
Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the <span>TW</span>i<span>TCH</span> trial Open
Summary Transcranial Doppler ( TCD ) With Transfusions Changing to Hydroxyurea ( TW i TCH ) trial is a randomized, open‐label comparison of hydroxycarbamide (also termed hydroxyurea) versus continued chronic transfusion therapy for primary…
View article: Systematic review of interventional sickle cell trials registered in ClinicalTrials.gov
Systematic review of interventional sickle cell trials registered in ClinicalTrials.gov Open
Background/Aims: The registry ClinicalTrials.gov was created to provide investigators and patients an accessible database of relevant clinical trials. Methods: To understand the state of sickle cell disease clinical trials, a comprehensive…
View article: Encephaloduroarteriosynangiosis and encephalomyoarteriosynangiosis for treatment of moyamoya syndrome in pediatric patients with sickle cell disease
Encephaloduroarteriosynangiosis and encephalomyoarteriosynangiosis for treatment of moyamoya syndrome in pediatric patients with sickle cell disease Open
OBJECT Pediatric patients with sickle cell disease (SCD) and moyamoya syndrome (MMS) are at significant risk for cerebrovascular accidents despite chronic transfusion therapy. Encephaloduroarteriosynangiosis (EDAS) and encephalomyoarterios…