Heon‐Jeong Lee
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View article: TTP enhances the sensitivity of KRASG12C-mutated lung cancer cells to KRASG12C inhibitors by downregulating SLC7A11 and promoting ferroptosis
TTP enhances the sensitivity of KRASG12C-mutated lung cancer cells to KRASG12C inhibitors by downregulating SLC7A11 and promoting ferroptosis Open
Covalent KRASG12C inhibitors are used to treat patients with KRASG12C-mutated non-small cell lung cancer (NSCLC). However, many patients do not respond to therapy due to intrinsic or acquired resistance. The mechanisms underlying resistanc…
View article: Deep phenotyping of insomnia: a multimodal assessment protocol
Deep phenotyping of insomnia: a multimodal assessment protocol Open
Background Insomnia is a highly prevalent condition, with heterogeneous clinical presentations and underlying mechanisms. Traditional assessment methods often fail to capture this complexity, thereby hindering the development of personaliz…
View article: Optimizing Winter‐Type Seasonality Criteria in East Asian Populations: A Machine Learning Approach Using the Seasonal Pattern Assessment Questionnaire
Optimizing Winter‐Type Seasonality Criteria in East Asian Populations: A Machine Learning Approach Using the Seasonal Pattern Assessment Questionnaire Open
Background The Seasonal Pattern Assessment Questionnaire (SPAQ) evaluates seasonal variations in mood and behavior. According to Kasper's criteria, individuals meeting diagnostic standards for seasonal affective disorder (SAD) or subsyndro…
View article: Light therapy for bipolar disorders: Clinical recommendations from the international society for bipolar disorders (ISBD) Chronobiology and Chronotherapy Task Force
Light therapy for bipolar disorders: Clinical recommendations from the international society for bipolar disorders (ISBD) Chronobiology and Chronotherapy Task Force Open
The International Society for Bipolar Disorders (ISBD) Chronobiology and Chronotherapy Task Force conducted a comprehensive review to deliver concise evidence-based recommendations on the use of bright light therapy (BLT) for bipolar disor…
View article: P-178 AI-driven radiomics analysis reveals morphological differences in oocyte aging: insights from machine learning classification of cytoplasmic features
P-178 AI-driven radiomics analysis reveals morphological differences in oocyte aging: insights from machine learning classification of cytoplasmic features Open
Study question Can AI-driven radiomics analysis identify distinct morphological changes in aging oocytes? Summary answer Radiomics-based AI models successfully classified oocytes by age and revealed oocytes from older mice exhibited larger…
View article: Machine learning-based prediction of restless legs syndrome using digital phenotypes from wearables and smartphone data
Machine learning-based prediction of restless legs syndrome using digital phenotypes from wearables and smartphone data Open
Restless legs syndrome (RLS) is a relatively common neurosensory disorder that causes an irresistible urge for leg movement. RLS causes sleep disturbances and reduced quality of life, but accurate diagnosis remains challenging owing to the…
View article: Development and Validation of a Wearable-Based Monitoring System for Predicting Psychiatric Crises in Inpatients: Study Protocol
Development and Validation of a Wearable-Based Monitoring System for Predicting Psychiatric Crises in Inpatients: Study Protocol Open
This study introduces a protocol to evaluate the feasibility and clinical utility of the Mental Instability and Risk Early Detection Monitoring System (MIR-Med System), a novel, digital monitoring platform designed for real-time detection …
View article: Exploring User Experience and the Therapeutic Relationship of Short-Term Avatar-Based Psychotherapy: Qualitative Pilot Study
Exploring User Experience and the Therapeutic Relationship of Short-Term Avatar-Based Psychotherapy: Qualitative Pilot Study Open
Background The rapid advancement of telehealth has led to the emergence of avatar-based psychotherapy (ABP), which combines the benefits of anonymity with nonverbal communication. With the adoption of remote mental health services, underst…
View article: Exploring the Psychological and Physiological Insights Through Digital Phenotyping by Analyzing the Discrepancies Between Subjective Insomnia Severity and Activity-Based Objective Sleep Measures: Observational Cohort Study
Exploring the Psychological and Physiological Insights Through Digital Phenotyping by Analyzing the Discrepancies Between Subjective Insomnia Severity and Activity-Based Objective Sleep Measures: Observational Cohort Study Open
Background Insomnia is a prevalent sleep disorder affecting millions worldwide, with significant impacts on daily functioning and quality of life. While traditionally assessed through subjective measures such as the Insomnia Severity Index…
View article: Machine learning prediction of anxiety symptoms in social anxiety disorder: utilizing multimodal data from virtual reality sessions
Machine learning prediction of anxiety symptoms in social anxiety disorder: utilizing multimodal data from virtual reality sessions Open
Introduction Machine learning (ML) is an effective tool for predicting mental states and is a key technology in digital psychiatry. This study aimed to develop ML algorithms to predict the upper tertile group of various anxiety symptoms ba…
View article: Managing Circadian Rhythms: A Key to Enhancing Mental Health in College Students
Managing Circadian Rhythms: A Key to Enhancing Mental Health in College Students Open
Objective To investigate the impact of circadian rhythm disruptions on mental health among college students and explore effective interventions for maintaining stable circadian rhythms.Methods A comprehensive review of literature was condu…
View article: Mental Health Status Profiles of Dentists in South Korea: A Latent Profile Analysis Approach
Mental Health Status Profiles of Dentists in South Korea: A Latent Profile Analysis Approach Open
Objective Dentists encounter unique occupational challenges, including stress, depression, and anxiety, that can impact their mental well-being. Therefore, it is essential to identify dentists’ mental health statuses and the factors influe…
View article: Comparisons of Genetic Architecture Using Polygenic Risk Scores Derived From Large-Scale Genome-Wide Association Study Data Between Patients With Schizophrenia, Bipolar Disorder and Healthy Controls
Comparisons of Genetic Architecture Using Polygenic Risk Scores Derived From Large-Scale Genome-Wide Association Study Data Between Patients With Schizophrenia, Bipolar Disorder and Healthy Controls Open
Objectives: In this study, we aimed to compare the genetic architecture of schizophrenia (SCZ) and bipolar disorder (BD) in a Korean population by analyzing polygenic risk scores (PRS) derived from large-scale psychiatric disorder genome-w…
View article: Exploring the Psychological and Physiological Insights Through Digital Phenotyping by Analyzing the Discrepancies Between Subjective Insomnia Severity and Activity-Based Objective Sleep Measures: Observational Cohort Study (Preprint)
Exploring the Psychological and Physiological Insights Through Digital Phenotyping by Analyzing the Discrepancies Between Subjective Insomnia Severity and Activity-Based Objective Sleep Measures: Observational Cohort Study (Preprint) Open
BACKGROUND Insomnia is a prevalent sleep disorder affecting millions worldwide, with significant impacts on daily functioning and quality of life. While traditionally assessed through subjective measures such as the Insomnia Severity Inde…
View article: Daily Self-Monitoring and Feedback of Circadian Rhythm Measures in Major Depression and Bipolar Disorder Using Wearable Devices and Smartphones–The Circadian Rhythm for Mood (CRM®) Trial Protocol: A Randomized Sham Controlled Double-Blind Trial
Daily Self-Monitoring and Feedback of Circadian Rhythm Measures in Major Depression and Bipolar Disorder Using Wearable Devices and Smartphones–The Circadian Rhythm for Mood (CRM®) Trial Protocol: A Randomized Sham Controlled Double-Blind Trial Open
The circadian rhythm for mood (CRM) is a digital therapeutic, which aims to prevent mood episode and improve clinical course in patients with major mood disorders. Developed on the circadian rhythm hypothesis of mood disorder, CRM predicts…
View article: Efficacy and Safety of Lurasidone vs. Quetiapine XR in Acutely Psychotic Patients With Schizophrenia in Korea: A Randomized, Double-Blind, Active-Controlled Trial
Efficacy and Safety of Lurasidone vs. Quetiapine XR in Acutely Psychotic Patients With Schizophrenia in Korea: A Randomized, Double-Blind, Active-Controlled Trial Open
Objective This study was performed to evaluate the efficacy and safety of lurasidone (160 mg/day) compared to quetiapine XR (QXR; 600 mg/day) in the treatment of acutely psychotic patients with schizophrenia.Methods Patients were randomly …
View article: P-516 Minimizing mosaicism: impact of trophectoderm (TE) biopsy specimen size on mosaic blastocysts in preimplantation genetic testing for aneuploidy (PGT-A)
P-516 Minimizing mosaicism: impact of trophectoderm (TE) biopsy specimen size on mosaic blastocysts in preimplantation genetic testing for aneuploidy (PGT-A) Open
Study question Is the size of TE biopsy specimens related to the chromosomal status of the blastocysts in PGT-A? Summary answer Smaller biopsy specimens are associated with higher proportion and altered composition of mosaic blastocysts in…
View article: Why Do Circadian Rhythms Exist?
Why Do Circadian Rhythms Exist? Open
Circadian rhythms have evolved as a result of adapting to the Earth's consistent 24-hour rotation and its 23.5-degree tilt while orbiting the Sun.These environmental conditions create daily and seasonal cycles, necessitating life forms to …
View article: Childhood maltreatment and suicide attempts in major depression and bipolar disorders in South Korea: A prospective nationwide cohort study
Childhood maltreatment and suicide attempts in major depression and bipolar disorders in South Korea: A prospective nationwide cohort study Open
Childhood maltreatment emerged as a robust predictor of SA among early-onset mood disorder patients. Systematic evaluation of CM early in the clinical process may be crucial for effective risk management. Additionally, our findings highlig…
View article: Efficacy of Mobile App–Based Cognitive Behavioral Therapy for Insomnia: Multicenter, Single-Blind Randomized Clinical Trial
Efficacy of Mobile App–Based Cognitive Behavioral Therapy for Insomnia: Multicenter, Single-Blind Randomized Clinical Trial Open
Background Cognitive behavioral therapy for insomnia (CBTi) is the first-line therapy for chronic insomnia. Mobile app–based CBTi (MCBTi) can enhance the accessibility of CBTi treatment; however, few studies have evaluated the effectivenes…
View article: Causal dynamics of sleep, circadian rhythm, and mood symptoms in patients with major depression and bipolar disorder: insights from longitudinal wearable device data
Causal dynamics of sleep, circadian rhythm, and mood symptoms in patients with major depression and bipolar disorder: insights from longitudinal wearable device data Open
Institute for Basic Science, the Human Frontiers Science Program Organization, the National Research Foundation of Korea, and the Ministry of Health & Welfare of South Korea.
View article: No Light at Night and Bright Light in the Morning
No Light at Night and Bright Light in the Morning Open
Smartphones, tablets, and other electronic devices that appeared 20 years ago have become an integral part of our lives, especially among adolescents and young adults.A growing body of research suggests that excessive exposure to blue ligh…
View article: Identifying predictive factors for mood recurrence in early-onset major mood disorders: A 4-year, multicenter, prospective cohort study
Identifying predictive factors for mood recurrence in early-onset major mood disorders: A 4-year, multicenter, prospective cohort study Open
We investigate the predictive factors of the mood recurrence in patients with early-onset major mood disorders from a prospective observational cohort study from July 2015 to December 2019. A total of 495 patients were classified into thre…
View article: Effects of a Rice-Farming Simulation Video Game on Nature Relatedness, Nutritional Status, and Psychological State in Urban-Dwelling Adults During the COVID-19 Pandemic: Randomized Waitlist Controlled Trial
Effects of a Rice-Farming Simulation Video Game on Nature Relatedness, Nutritional Status, and Psychological State in Urban-Dwelling Adults During the COVID-19 Pandemic: Randomized Waitlist Controlled Trial Open
Background During the COVID-19 pandemic, urban inhabitants faced significant challenges in maintaining connections with nature, adhering to nutritional guidelines, and managing mental well-being. Objective Recognizing the urgent need for i…
View article: Sleeping Pills and Increased Mortality and Suicide
Sleeping Pills and Increased Mortality and Suicide Open
If you suffer from insomnia, it is easy to be tempted by sleeping pills that promise to make it easier to fall asleep.With the advent of Z-drugs, which claim to have fewer side effects than previous sleeping pills, they tend to be over-pre…