Lee M. Booty
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View article: The chemokines CCL22 and CCL17 are a defining feature of type 2 stimulated human lung macrophages and exhibit different metabolic dependencies
The chemokines CCL22 and CCL17 are a defining feature of type 2 stimulated human lung macrophages and exhibit different metabolic dependencies Open
Introduction Although human lung macrophages are heterogenous and play key roles during health and disease, the mechanisms that govern their activation and function are unclear, particularly in type 2 settings. Our understanding of how hum…
View article: Pulmonary macrophage subsets display distinct metabolic responses to polarising stimuli <i>in vivo</i>
Pulmonary macrophage subsets display distinct metabolic responses to polarising stimuli <i>in vivo</i> Open
Macrophage activation is underpinned by metabolic changes required to fight infection, resolve inflammation and enable effective wound healing. While metabolic control of macrophage activation is increasingly understood in culture systems …
View article: Integrated metabolic-transcriptomic network identifies immunometabolic modulations in human macrophages
Integrated metabolic-transcriptomic network identifies immunometabolic modulations in human macrophages Open
Macrophages exhibit diverse phenotypes and respond flexibly to environmental cues through metabolic remodeling. In this study, we present a comprehensive multi-omics dataset integrating intra- and extracellular metabolomes with transcripto…
View article: Highlight of 2023: The metabolic symphony – orchestrating T‐cell immunity
Highlight of 2023: The metabolic symphony – orchestrating T‐cell immunity Open
The significance of metabolites in orchestrating immune cells is now recognized to be on par with other key immune modulators, such as cytokines or chemokines. Seminal discoveries have now been built upon with discoveries that have acted t…
View article: C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages
C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages Open
The complement system mediates diverse regulatory immunological functions. C5aR2, an enigmatic receptor for anaphylatoxin C5a, has been shown to modulate PRR-dependent pro-inflammatory cytokine secretion in human macrophages. However, the …
View article: Gasdermins assemble; recent developments in bacteriology and pharmacology
Gasdermins assemble; recent developments in bacteriology and pharmacology Open
The discovery of gasdermin D (GSDMD) as the terminal executioner of pyroptosis provided a large piece of the cell death puzzle, whilst simultaneously and firmly putting the gasdermin family into the limelight. In its purest form, GSDMD pro…
View article: Integrated Metabolic-Transcriptomic Network Identifies Novel Immunometabolic Modulations in Human Macrophages
Integrated Metabolic-Transcriptomic Network Identifies Novel Immunometabolic Modulations in Human Macrophages Open
View article: IL-10 Drives Glycolysis and Hinders Mitochondrial Pathways in Human Macrophages: Implications for Inflammatory Bowel Disease and Anti-TNF Treatment
IL-10 Drives Glycolysis and Hinders Mitochondrial Pathways in Human Macrophages: Implications for Inflammatory Bowel Disease and Anti-TNF Treatment Open
View article: Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages
Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages Open
The complement system is an ancient and critical part of innate immunity. Recent studies have highlighted novel roles of complement beyond lysis of invading pathogens with implications in regulating the innate immune response, as well as c…
View article: Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication Open
Human rhinovirus (HRV), like coronavirus (HCoV), are positive-strand RNA viruses that cause both upper and lower respiratory tract illness, with their replication facilitated by concentrating RNA-synthesizing machinery in intracellular com…
View article: Sublytic membrane attack complex drives glycolysis and mitochondrial dysfunction with inflammatory consequences in human monocyte-derived macrophages
Sublytic membrane attack complex drives glycolysis and mitochondrial dysfunction with inflammatory consequences in human monocyte-derived macrophages Open
The complement system is an ancient and critical element of the innate immune system. The terminal step in the complement pathway, the membrane attack complex (MAC), has previously been linked to inflammasome activation and is linked to th…
View article: <i>Salmonella</i> Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages
<i>Salmonella</i> Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages Open
Infection of human macrophages with Salmonella enterica serovar Typhimurium (S. Typhimurium) leads to inflammasome activation. Inflammasomes are multiprotein complexes facilitating caspase-1 activation and subsequent gasdermin D–mediated c…
View article: NLR in eXile: Emerging roles of NLRX1 in immunity and human disease
NLR in eXile: Emerging roles of NLRX1 in immunity and human disease Open
Summary NLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its NLR counterparts with unique features that medi…
View article: Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo
Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo Open
Purpose Mitochondrial reactive oxygen species (ROS) production upon reperfusion of ischemic tissue initiates the ischemia/reperfusion (I/R) injury associated with heart attack. During ischemia, succinate accumulates and its oxidation upon …
View article: Chopping <scp>GSDMD</scp> : caspase‐8 has joined the team of pyroptosis‐mediating caspases
Chopping <span>GSDMD</span> : caspase‐8 has joined the team of pyroptosis‐mediating caspases Open
View article: Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo
Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo Open
View article: Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 Open
View article: Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation
Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation Open
View article: The mitochondrial dicarboxylate and 2‐oxoglutarate carriers do not transport glutathione
The mitochondrial dicarboxylate and 2‐oxoglutarate carriers do not transport glutathione Open
Glutathione carries out vital protective roles within mitochondria, but is synthesised in the cytosol. Previous studies have suggested that the mitochondrial dicarboxylate and 2‐oxoglutarate carriers were responsible for glutathione uptake…