Lee Schmalz
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View article: Multivariate protein landscape of host response in hospitalised patients with suspected infection in the emergency department
Multivariate protein landscape of host response in hospitalised patients with suspected infection in the emergency department Open
Suspected infection requiring hospitalisation has highly heterogenous presentation. Yet, variances in host response and its implications are largely unknown. In this multicentre cohort of 3802 individual patients presenting to the Emergenc…
View article: Development and Validation of the First FDA Authorized Artificial Intelligence/Machine Learning Diagnostic Tool for the Prediction of Sepsis Risk
Development and Validation of the First FDA Authorized Artificial Intelligence/Machine Learning Diagnostic Tool for the Prediction of Sepsis Risk Open
Background Sepsis is a life-threatening condition that demands prompt treatment for improved patient outcomes. Its heterogenous presentation makes early detection challenging, highlighting the need for effective risk assessment tools. Arti…
View article: Analysis of Protein Biomarkers From Hospitalized COVID-19 Patients Reveals Severity-Specific Signatures and Two Distinct Latent Profiles With Differential Responses to Corticosteroids*
Analysis of Protein Biomarkers From Hospitalized COVID-19 Patients Reveals Severity-Specific Signatures and Two Distinct Latent Profiles With Differential Responses to Corticosteroids* Open
OBJECTIVES: To identify and validate novel COVID-19 subphenotypes with potential heterogenous treatment effects (HTEs) using electronic health record (EHR) data and 33 unique biomarkers. DESIGN: Retrospective cohort study of adults present…