Lee W. Riley
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View article: Mycolic acid and cholesterol induced transcriptomic adaptations in wild type and Mce complex ATPase subunit deleted strain of<i>M. tuberculosis</i>H37Rv
Mycolic acid and cholesterol induced transcriptomic adaptations in wild type and Mce complex ATPase subunit deleted strain of<i>M. tuberculosis</i>H37Rv Open
During infection and latency, Mycobacterium tuberculosis (Mtb) primarily relies on lipids as its main energy source. The Mtb mammalian cell entry (Mce) complexes function as lipid transporters with Mkl as the ATPase subunit for substrate t…
View article: Predictors of upper respiratory<i>Streptococcus pneumoniae</i>colonization among working-age adults with prevalent exposure to overcrowding
Predictors of upper respiratory<i>Streptococcus pneumoniae</i>colonization among working-age adults with prevalent exposure to overcrowding Open
Background The epidemiology of adult pneumococcal carriage remains poorly understood. We assessed risk factors for pneumococcal carriage among adults in socioeconomically-disadvantaged farmworker communities with prevalent overcrowding. Me…
View article: A Matter of Inclusion: A Cluster-Randomized Trial to Access the Effect of Food Vouchers Versus Traditional Treatment on Tuberculosis Outcomes in Brazil
A Matter of Inclusion: A Cluster-Randomized Trial to Access the Effect of Food Vouchers Versus Traditional Treatment on Tuberculosis Outcomes in Brazil Open
We assessed the effectiveness of food vouchers as a social protection strategy to enhance the adherence to tuberculosis treatment in health-care facilities in Brazil between 2014 and 2017. A cluster-randomized controlled trial was performe…
View article: Risk factors for extended-spectrum beta-lactamase (ESBL) producing<i>E. coli</i>carriage among children in a food animal producing region of Quito, Ecuador
Risk factors for extended-spectrum beta-lactamase (ESBL) producing<i>E. coli</i>carriage among children in a food animal producing region of Quito, Ecuador Open
Background The spread of antibiotic-resistant bacteria may be driven by human-animal-environment interactions, especially in regions with limited restrictions on antibiotic use, widespread food animal production, and free-roaming domestic …
View article: Key Role of Multidisciplinary Collaboration towards Global Elimination of HCV Infection
Key Role of Multidisciplinary Collaboration towards Global Elimination of HCV Infection Open
The elimination of HCV (hepatitis C virus) infection is, according to WHO (World Health Organization), of international interest. With new diagnostic tools and treatment possibilities, one major challenge for the elimination is to involve …
View article: Genetic features of antimicrobial drug-susceptible extraintestinal pathogenic<i>Escherichia coli</i>pandemic sequence type 95
Genetic features of antimicrobial drug-susceptible extraintestinal pathogenic<i>Escherichia coli</i>pandemic sequence type 95 Open
Extraintestinal pathogenic Escherichia coli (ExPEC) belonging to multilocus sequence type 95 (ST95) is one of the most geographically widespread ExPEC lineages causing bloodstream (BSI) and urinary tract infections (UTI). In contrast to ot…
View article: A rapid, antibiotic susceptibility test for multidrug-resistant, Gram-negative bacterial uropathogens using the biochemical assay, DETECT
A rapid, antibiotic susceptibility test for multidrug-resistant, Gram-negative bacterial uropathogens using the biochemical assay, DETECT Open
View article: Distinguishing Pathovars from Nonpathovars: Escherichia coli
Distinguishing Pathovars from Nonpathovars: Escherichia coli Open
Escherichia coli is one of the most well-adapted and pathogenically versatile bacterial organisms. It causes a variety of human infections, including gastrointestinal illnesses and extraintestinal infections. It is also part of the intesti…
View article: A Dual Enzyme-Based Biochemical Test Rapidly Detects Third-Generation Cephalosporin-Resistant CTX-M-Producing Uropathogens in Clinical Urine Samples
A Dual Enzyme-Based Biochemical Test Rapidly Detects Third-Generation Cephalosporin-Resistant CTX-M-Producing Uropathogens in Clinical Urine Samples Open
Extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacteria (GNB) are increasingly identified as the cause of both community and healthcare-associated urinary tract infections (UTIs), with CTX-Ms being the most common ESBLs ident…
View article: Reviews of "Remarkable Variability in SARS-CoV-2 Antibodies across Brazilian Regions: Report on Two Successive Nationwide Serological Household Surveys"
Reviews of "Remarkable Variability in SARS-CoV-2 Antibodies across Brazilian Regions: Report on Two Successive Nationwide Serological Household Surveys" Open
of Reviews: As one of the only large-scale, population-based national serosurveys reported to date, this study makes significant contributions to our understanding of COVID-19 on populations including seroprevalance between age groups and …
View article: Antimicrobial Drug-Resistant Gram-Negative Saprophytic Bacteria Isolated from Ambient, Near-Shore Sediments of an Urbanized Estuary: Absence of β-Lactamase Drug-Resistance Genes
Antimicrobial Drug-Resistant Gram-Negative Saprophytic Bacteria Isolated from Ambient, Near-Shore Sediments of an Urbanized Estuary: Absence of β-Lactamase Drug-Resistance Genes Open
We assessed the prevalence of antimicrobial resistance and screened for clinically relevant β-lactamase resistance determinants in Gram-negative bacteria from a large urbanized estuary. In contrast to the broad literature documenting poten…
View article: Slum Health: Arresting COVID-19 and Improving Well-Being in Urban Informal Settlements
Slum Health: Arresting COVID-19 and Improving Well-Being in Urban Informal Settlements Open
View article: Slum Health: Arresting COVID-19 and Improving Well-Being in Urban Informal Settlements.
Slum Health: Arresting COVID-19 and Improving Well-Being in Urban Informal Settlements. Open
The informal settlements of the Global South are the least prepared for the pandemic of COVID-19 since basic needs such as water, toilets, sewers, drainage, waste collection, and secure and adequate housing are already in short supply or n…
View article: Multilocus sequence typing of <i>Escherichia coli</i> isolates from urinary tract infection patients and from fecal samples of healthy subjects in a college community
Multilocus sequence typing of <i>Escherichia coli</i> isolates from urinary tract infection patients and from fecal samples of healthy subjects in a college community Open
Community‐acquired urinary tract infections (UTIs) are one of the most common bacterial infections worldwide. Escherichia coli is the most common cause of community‐acquired UTI. In general, UTI results from E. coli in the intestine that e…
View article: Risk factors for fecal carriage of drug-resistant Escherichia coli: a systematic review and meta-analysis
Risk factors for fecal carriage of drug-resistant Escherichia coli: a systematic review and meta-analysis Open
View article: Additional file 3 of Risk factors for fecal carriage of drug-resistant Escherichia coli: a systematic review and meta-analysis
Additional file 3 of Risk factors for fecal carriage of drug-resistant Escherichia coli: a systematic review and meta-analysis Open
Additional file 3 Reference information for excluded articles and reasons for exclusion.
View article: Prevalence of beta-lactam drug-resistance genes in commensal <i>Escherichia coli</i> contaminating ready-to-eat lettuce
Prevalence of beta-lactam drug-resistance genes in commensal <i>Escherichia coli</i> contaminating ready-to-eat lettuce Open
The objective of this study was to evaluate the prevalence of antibiotic resistance and beta-lactam drug resistance genes in Escherichia coli isolated from ready-to-eat lettuce, obtained from local supermarkets in Northern California. Bags…
View article: Diversity of clonal types of Klebsiella pneumoniae causing infections in intensive care neonatal patients in a large urban setting
Diversity of clonal types of Klebsiella pneumoniae causing infections in intensive care neonatal patients in a large urban setting Open
View article: Differentiating Epidemic from Endemic or Sporadic Infectious Disease Occurrence
Differentiating Epidemic from Endemic or Sporadic Infectious Disease Occurrence Open
One important scope of work of epidemiology is the investigation of infectious diseases that cluster in time and place. Clusters of infectious disease may represent outbreaks or epidemics in which the cases share in common a point source e…
View article: Prevalence of antimicrobial resistance genes and integrons in commensal Gram-negative bacteria in a college community
Prevalence of antimicrobial resistance genes and integrons in commensal Gram-negative bacteria in a college community Open
Although the human intestinal microbiome has been shown to harbor antimicrobial drug-resistance genes (ARG), the prevalence of such genes in a healthy population and their impact on extraintestinal infections that occur in that community a…
View article: Differences in gram-positive bacterial colonization and antimicrobial resistance among children in a high income inequality setting
Differences in gram-positive bacterial colonization and antimicrobial resistance among children in a high income inequality setting Open
View article: Children Born to Mothers with Rash During Zika Virus Epidemic in Brazil: First 18 Months of Life
Children Born to Mothers with Rash During Zika Virus Epidemic in Brazil: First 18 Months of Life Open
Objective To better understand the clinical spectrum and course of congenital Zika syndrome (CZS) during the first 18 months of life of children whose mothers had rash during pregnancy. Methods This longitudinal observational study evaluat…
View article: Extraintestinal Pathogenic Escherichia coli and Antimicrobial Drug Resistance in a Maharashtrian Drinking Water System
Extraintestinal Pathogenic Escherichia coli and Antimicrobial Drug Resistance in a Maharashtrian Drinking Water System Open
Although access to piped drinking water continues to increase globally, information on the prevalence and clonal composition of coliforms found in piped water systems in low-resource settings remains limited. From June to July 2016, we exa…
View article: Nutrients in Runoff from Cotton Production in the Lower Mississippi River Basin: An On‐Farm Study
Nutrients in Runoff from Cotton Production in the Lower Mississippi River Basin: An On‐Farm Study Open
Agrosystems, Geosciences & Environment 1 of 1 3.In Table 9 (page 8), the "P applied as fertilizer" and the "Loss in runoff " columns were incorrect.The corrected Table 9 is shown below.4. In the text on page 9, the original was: When avera…
View article: Effect of the Bolsa Familia Programme on the outcome of tuberculosis treatment: a prospective cohort study
Effect of the Bolsa Familia Programme on the outcome of tuberculosis treatment: a prospective cohort study Open
View article: Advances in Molecular Epidemiology of Infectious Diseases: Definitions, Approaches, and Scope of the Field
Advances in Molecular Epidemiology of Infectious Diseases: Definitions, Approaches, and Scope of the Field Open
Molecular epidemiology is a discipline that uses molecular microbiology tools to study the distribution and determinants of diseases in human populations and veterinary animals. Our understanding of epidemiology of infectious diseases has …
View article: Laboratory Methods in Molecular Epidemiology: Bacterial Infections
Laboratory Methods in Molecular Epidemiology: Bacterial Infections Open
In infectious disease epidemiology, the laboratory plays a critical role in diagnosis, outbreak investigations, surveillance, and characterizing biologic properties of microbes associated with their transmissibility, resistance to anti-inf…
View article: Cover Feature: An Enzyme‐Mediated Amplification Strategy Enables Detection of β‐Lactamase Activity Directly in Unprocessed Clinical Samples for Phenotypic Detection of β‐Lactam Resistance (ChemBioChem 20/2018)
Cover Feature: An Enzyme‐Mediated Amplification Strategy Enables Detection of β‐Lactamase Activity Directly in Unprocessed Clinical Samples for Phenotypic Detection of β‐Lactam Resistance (ChemBioChem 20/2018) Open
The cover feature picture shows a pictorial representation of the enzyme-empowered amplification technology, DETECT. This amplification strategy was applied to enhance the detection of the antibiotic resistance-conferring enzyme, β-lactama…
View article: Population structure of Streptococcus pneumoniae colonizing children before and after universal use of pneumococcal conjugate vaccines in Brazil: emergence and expansion of the MDR serotype 6C-CC386 lineage
Population structure of Streptococcus pneumoniae colonizing children before and after universal use of pneumococcal conjugate vaccines in Brazil: emergence and expansion of the MDR serotype 6C-CC386 lineage Open
Although PNSP strains were polyclonal, most resistant isolates belonged to a single genotype from each period. Higher erythromycin resistance prevalence (42%) in the post-PCV10/13 period was mainly attributed to MDR serotype 6C-CC386. Ongo…
View article: Prevalence and risk factors for latent tuberculosis infection among primary health care workers in Brazil
Prevalence and risk factors for latent tuberculosis infection among primary health care workers in Brazil Open
Health care workers (HCW) are at increased risk of latent tuberculosis infection (LTBI) from occupational exposure to Mycobacterium tuberculosis. The objective was to determine the prevalence of and risk factors for LTBI among primary HCW …