Leena Choi
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View article: IMpact of PerioperAtive KeTamine on Enhanced Recovery After abdominal Surgery (IMPAKT ERAS): a pragmatic randomised single-cluster trial
IMpact of PerioperAtive KeTamine on Enhanced Recovery After abdominal Surgery (IMPAKT ERAS): a pragmatic randomised single-cluster trial Open
NCT04625283.
View article: Barriers to growth hormone access in pediatric patients at an academic medical center
Barriers to growth hormone access in pediatric patients at an academic medical center Open
Purpose Evaluating barriers that may delay or limit human growth hormone (hGH) access is important to ensure timely and equitable treatment. We examined time to hGH access and whether time to approval was associated with patient factors an…
View article: Ustekinumab infusion to subcutaneous transition: Coordinating care and identifying potential gaps
Ustekinumab infusion to subcutaneous transition: Coordinating care and identifying potential gaps Open
Ustekinumab initiation and escalation within the first year can be a complex process requiring a high level of care coordination to ensure patients receive timely therapy while reducing potential waste.
View article: Pediatric and Adolescent Hepatitis C Care Cascade and Real-World Treatment Outcomes Utilizing an Integrated Health System Specialty Pharmacy Model
Pediatric and Adolescent Hepatitis C Care Cascade and Real-World Treatment Outcomes Utilizing an Integrated Health System Specialty Pharmacy Model Open
Objectives This study evaluated the Cascade of Care (CoC) and real-world efficacy of direct-acting antivirals (DAAs) for hepatitis C treatment in pediatric and adolescent patients utilizing an integrated health system specialty pharmacy (H…
View article: Transcriptomic signatures in response to antioxidants supplementation in Korean cattle beef, Hanwoo: a 7-month feeding study
Transcriptomic signatures in response to antioxidants supplementation in Korean cattle beef, Hanwoo: a 7-month feeding study Open
Introduction The present study investigated the effects of antioxidant supplementation on the transcriptomic profiles of Hanwoo cattle during a 7-month feeding trial. Methods Twelve castrated Hanwoo cattle were randomly assigned to two gro…
View article: Pharmacist tailored monitoring for patients initiating encorafenib and binimetinib combination therapy
Pharmacist tailored monitoring for patients initiating encorafenib and binimetinib combination therapy Open
Introduction: Combination therapy with protein kinase B-raf (BRAF) inhibitor, encorafenib, and mitogen-activated extracellular kinase (MEK) inhibitor, binimetinib, is associated with adverse events (AEs) that can lead to therapy changes ea…
View article: Deutetrabenazine treatment outcomes with doses above U.S. Food and Drug Administration maximum approved doses in Huntington's disease chorea: A dual-site analysis
Deutetrabenazine treatment outcomes with doses above U.S. Food and Drug Administration maximum approved doses in Huntington's disease chorea: A dual-site analysis Open
Background Deutetrabenazine, a vesicular monoamine transporter 2 inhibitor, is one of few treatment options available for Huntington's disease (HD) chorea. There is limited data describing clinical experience with deutetrabenazine doses >4…
View article: Integrated health system pharmacy role in adherence, persistence, and adverse effect management for oral chronic lymphocytic leukemia therapy.
Integrated health system pharmacy role in adherence, persistence, and adverse effect management for oral chronic lymphocytic leukemia therapy. Open
In a population of patients initiating oral CLL/SLL therapy through an integrated health system specialty pharmacy, adherence and persistence to therapy was high. Adverse effects were attributed in 36% of therapy discontinuations and 72% o…
View article: Getting to specialty treatment in dermatologic inflammatory conditions: Treatment requirements and patient journey
Getting to specialty treatment in dermatologic inflammatory conditions: Treatment requirements and patient journey Open
Most patients required to complete nonspecialty step therapy ultimately initiated specialty medications after a lengthy delay, demonstrating the potential impact of step therapy requirements on initiating clinically appropriate treatment f…
View article: SUN-477 The Gut Microbe Rothia Mucilaginosa Induces a Polycystic Ovarian Syndrome-Like Phenotype in a Rat Model
SUN-477 The Gut Microbe Rothia Mucilaginosa Induces a Polycystic Ovarian Syndrome-Like Phenotype in a Rat Model Open
G. Parodi: None. R. de Souza Santos: None. G. Leite: None. F. Medeiros: None. G.M. Barlow: None. W. Morales: None. S.R. Weitsman: None. M. Sanchez: None. I. Rivera: None. M. Villanueva-Millan: None. F. Faria: None. D. Flor: None. L. Choi: …
View article: Are We Dosing Correctly? Population Pharmacokinetics of Cefepime in Critically Ill Pediatric Patients
Are We Dosing Correctly? Population Pharmacokinetics of Cefepime in Critically Ill Pediatric Patients Open
Background Dosing guidelines of cefepime are well defined in healthy pediatric and adult populations but have not been extensively studied in critically ill pediatric patients. Patients who are critically ill may have significant alteratio…
View article: Evaluating Antibiotic De-escalation for Autologous Stem Cell Transplant Patients With Febrile Neutropenia in a Real-World Clinical Setting
Evaluating Antibiotic De-escalation for Autologous Stem Cell Transplant Patients With Febrile Neutropenia in a Real-World Clinical Setting Open
Febrile neutropenia (FN) is a complication in approximately 90% of autologous stem cell transplant (SCT) patients. Guidelines support early broad-spectrum antibiotics (BSA) to prevent morbidity and mortality. However, in patients who are c…
View article: Developing a natural language processing system using transformer-based models for adverse drug event detection in electronic health records
Developing a natural language processing system using transformer-based models for adverse drug event detection in electronic health records Open
Objective To develop a transformer-based natural language processing (NLP) system for detecting adverse drug events (ADEs) from clinical notes in electronic health records (EHRs). Materials and Methods We fine-tuned BERT Short-Formers and …
View article: Evaluating patient-reported adherence and outcomes in specialty disease states: A dual-site initiative
Evaluating patient-reported adherence and outcomes in specialty disease states: A dual-site initiative Open
Patients filling rheumatology or MS specialty medications within health system specialty pharmacies reported high rates of medication effectiveness and adherence and low rates of issues with tolerability and HCRU. Patients who report toler…
View article: Using electronic health records for clinical pharmacology research: Challenges and considerations
Using electronic health records for clinical pharmacology research: Challenges and considerations Open
Electronic health records (EHRs) contain a vast array of phenotypic data on large numbers of individuals, often collected over decades. Due to the wealth of information, EHR data have emerged as a powerful resource to make first discoverie…
View article: Financial impact of integrated specialty pharmacy efforts to avoid oral anticancer medication waste
Financial impact of integrated specialty pharmacy efforts to avoid oral anticancer medication waste Open
Integrated health system specialty pharmacist postponement of refill requests after review of the amount of medication on hand and upcoming follow-up proved effective in avoiding waste and unnecessary medication costs in patients treated w…
View article: Cost avoidance from health system specialty pharmacist interventions in patients with multiple sclerosis
Cost avoidance from health system specialty pharmacist interventions in patients with multiple sclerosis Open
There is a potential for significant health care savings after specialty pharmacist interventions in MS, primarily from preventing the dispensing of inappropriate therapies.
View article: Adherence and discontinuation of prescription cannabidiol for the management of seizure disorders at an integrated care center
Adherence and discontinuation of prescription cannabidiol for the management of seizure disorders at an integrated care center Open
Adherence to prescription CBD at an integrated care center was high with approximately 94% of patients considered adherent. Providers and pharmacists may improve adherence and discontinuation rates by educating patients on the timeline of …
View article: Primary medication nonadherence rates to specialty disease-modifying antirheumatic drugs for rheumatoid arthritis within a health system specialty pharmacy
Primary medication nonadherence rates to specialty disease-modifying antirheumatic drugs for rheumatoid arthritis within a health system specialty pharmacy Open
BACKGROUND: Assessing primary medication nonadherence, the rate at which a medication is prescribed for a patient but is not obtained or replaced with an alternative medication within a reasonable time period, can provide a better understa…
View article: Low rates of primary medication nonadherence in patients prescribed oral oncology agents across health system specialty pharmacies
Low rates of primary medication nonadherence in patients prescribed oral oncology agents across health system specialty pharmacies Open
BACKGROUND: New oral oncology medications bring novel challenges when patients are initiating treatment. Rates of primary medication nonadherence (PMN), the rate at which a medication is prescribed but not obtained, of up to 30% have been …
View article: <scp>Variant‐based</scp> heritability assessment of dexmedetomidine and fentanyl clearance in pediatric patients
<span>Variant‐based</span> heritability assessment of dexmedetomidine and fentanyl clearance in pediatric patients Open
Despite complex pathways of drug disposition, clinical pharmacogenetic predictors currently rely on only a few high effect variants. Quantification of the polygenic contribution to variability in drug disposition is necessary to prioritize…
View article: Sensitivity of estimated tacrolimus population pharmacokinetic profile to assumed dose timing and absorption in real‐world data and simulated data
Sensitivity of estimated tacrolimus population pharmacokinetic profile to assumed dose timing and absorption in real‐world data and simulated data Open
Aims Use of electronic health record (EHR) data to estimate population pharmacokinetic (PK) profiles necessitates several assumptions. We sought to investigate sensitivity to some of these assumptions about dose timing and absorption rates…
View article: Population pharmacokinetic analysis of dexmedetomidine in children using real‐world data from electronic health records and remnant specimens
Population pharmacokinetic analysis of dexmedetomidine in children using real‐world data from electronic health records and remnant specimens Open
Aims Our objectives were to perform a population pharmacokinetic analysis of dexmedetomidine in children using remnant specimens and electronic health records (EHRs) and explore the impact of patient's characteristics and pharmacogenetics …
View article: Effect of CYP3A5 and CYP3A4 Genetic Variants on Fentanyl Pharmacokinetics in a Pediatric Population
Effect of CYP3A5 and CYP3A4 Genetic Variants on Fentanyl Pharmacokinetics in a Pediatric Population Open
Fentanyl is an anesthetic/analgesic commonly used in surgical and recovery settings. CYP3A4 and CYP3A5 encode enzymes, which metabolize fentanyl; genetic variants in these genes impact fentanyl pharmacokinetics in adults. Pharmacokinetic (…
View article: Adherence to self-administered biologic disease-modifying antirheumatic drugs across health-system specialty pharmacies
Adherence to self-administered biologic disease-modifying antirheumatic drugs across health-system specialty pharmacies Open
Purpose Adherence to self-administered biologic disease-modifying antirheumatic drugs (bDMARDs) is necessary for therapeutic benefit. Health-system specialty pharmacies (HSSPs) have reported high adherence rates across several disease stat…
View article: DrugWAS: Drug‐wide Association Studies for COVID‐19 Drug Repurposing
DrugWAS: Drug‐wide Association Studies for COVID‐19 Drug Repurposing Open
This study aimed to systematically investigate if any of the available drugs in the electronic health record (EHR) can be repurposed as potential treatment for coronavirus disease 2019 (COVID‐19). Based on a retrospective cohort analysis o…