Leena Dennis Joseph
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View article: Therapeutic Targeting of <i>Low-density lipoprotein receptor-related protein-1</i> (<i>LRP1</i>) gene in Ovarian Cancer: A Comprehensive Review
Therapeutic Targeting of <i>Low-density lipoprotein receptor-related protein-1</i> (<i>LRP1</i>) gene in Ovarian Cancer: A Comprehensive Review Open
Low-density lipoprotein receptor-related protein 1 (LRP1, also known as CD91) is a multifunctional endocytic and cell-signalling receptor widely expressed in various cell types, including neurons, fibroblasts, hepatocytes, muscle cells, as…
View article: Aggressive Pulmonary Mucoepidermoid carcinoma in Adolescence: A case Report (Highlighting Diagnostic and Management Challenges)
Aggressive Pulmonary Mucoepidermoid carcinoma in Adolescence: A case Report (Highlighting Diagnostic and Management Challenges) Open
Pulmonary mucoepidermoid carcinoma (PMEC) is an extremely rare salivary gland-type tumor that arises from submucosal bronchial glands and accounts for less than 1% of lung tumors. Here we describe a very unusual case of high-grade PMEC in …
View article: Effective Management of Familial Erythrokeratoderma Using Topical Calcipotriol
Effective Management of Familial Erythrokeratoderma Using Topical Calcipotriol Open
Progressive symmetrical erythrokeratoderma (PSEK) is a rare genodermatosis that is inherited in an autosomal dominant pattern. It is clinically characterized by the insidious onset of well-defined, non-migratory, erythematous, hyperkeratot…
View article: Spectrum of Typical and Atypical Imaging Findings and Pathological Features in Diabetic Mastopathy
Spectrum of Typical and Atypical Imaging Findings and Pathological Features in Diabetic Mastopathy Open
Diabetic mastopathy (DMP) is a rare fibroinflammatory condition of the breast seen in patients with diabetes mellitus (DM), which mimics malignancy on imaging. We present eight cases of biopsy-proven DMP with typical (1/8 cases) and atypic…
View article: Congenital cardiac anomalies detected in fetal autopsies: a case series
Congenital cardiac anomalies detected in fetal autopsies: a case series Open
Congenital cardiac anomalies are among the most common structural malformations of the developing fetus and account for a high percentage of fetal morbidity and mortality. Timely detection and comprehensive assessment are important in pren…
View article: Congenital urogenital anomalies detected in foetal autopsies: a case series
Congenital urogenital anomalies detected in foetal autopsies: a case series Open
Foetal anomalies are congenital defects that can affect multiple organ systems, including the urogenital system. Congenital anomalies of the kidney and urinary tract (CAKUT) are a significant subset of these disorders, often leading to sev…
View article: Morphology to molecular subtyping: Retrospective study to correlate the molecular subtypes of breast cancer with mammography and ultrasound imaging features
Morphology to molecular subtyping: Retrospective study to correlate the molecular subtypes of breast cancer with mammography and ultrasound imaging features Open
Objectives To identify the imaging features of malignant breast masses on mammogram and ultrasound. To correlate the morphological features of these masses with immunohistochemistry markers for different molecular subtypes of breast cancer…
View article: A Case of Orofacial Granulomatosis Treated With Intravenous Rituximab
A Case of Orofacial Granulomatosis Treated With Intravenous Rituximab Open
Orofacial granulomatosis (OFG) encompasses a range of conditions marked by granuloma formation in the oral and perioral tissues. We report a 32-year-old female with asymptomatic swelling of the lower lip, buccal mucosa, and lower face, acc…
View article: Signet Rings Beyond the Norm: A Report of Two Rare Cases
Signet Rings Beyond the Norm: A Report of Two Rare Cases Open
Pulmonary adenocarcinoma with Signet Ring Cell (SRC) morphology is a very rare and distinct subtype initially classified as signet ring adenocarcinoma in the 2004 World Health Organisation (WHO) classification of lung tumours. In the 2015 …
View article: Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma
Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma Open
Circulating tumor DNA (ctDNA) detection can predict clinical risk in early-stage tumors. However, clinical applications are constrained by the sensitivity of clinically validated ctDNA detection approaches. NeXT Personal is a whole-genome-…
View article: Tuberculosis presenting with multiple osteolytic lesions in an adolescent boy with fanconi anemia
Tuberculosis presenting with multiple osteolytic lesions in an adolescent boy with fanconi anemia Open
Tuberculosis (TB) is well known to present with varied clinical and radiological features. Multifocal bone involvement in tuberculosis is rare. Multiple lytic lesions raise the possibility of malignancy usually, especially, in children wit…
View article: Preliminary phytochemical evaluation of methanol extracts of momordica dioica roxb
Preliminary phytochemical evaluation of methanol extracts of momordica dioica roxb Open
Momordica dioica, commonly known as spiny gourd, teasle gourd, or kakrol, is a perennial, dioecious climbing plant belonging to the Cucurbitaceae family. This versatile plant is not only used as a food source but also plays a role in preve…
View article: Clinically Suspicious Cases of Hansen's Disease at a Tertiary Care Hospital in South India: A Clinicopathological Study
Clinically Suspicious Cases of Hansen's Disease at a Tertiary Care Hospital in South India: A Clinicopathological Study Open
Background and objective Hansen's disease, also known as leprosy, is a chronic granulomatous condition caused by Mycobacterium leprae, primarily affecting the skin and peripheral nerves. The disease has a wide spectrum of clinical and hist…
View article: Spectrum of Ductal Carcinoma In Situ (DCIS) Lesions of the Breast: From Morphology to Molecular Characteristics
Spectrum of Ductal Carcinoma In Situ (DCIS) Lesions of the Breast: From Morphology to Molecular Characteristics Open
Background Specific molecular characteristics of invasive breast cancer have been linked to an increased risk of early relapse. Similarly, ductal carcinoma in situ (DCIS) displays a comparable molecular profile, although their prevalence a…
View article: Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling Open
The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis of mixed intra-patient tumor responses remains unclear. He…
View article: Clinical management of bullous pemphigoid—The importance of cytology in diagnosis
Clinical management of bullous pemphigoid—The importance of cytology in diagnosis Open
Bullous pemphigoid (BP) is a common immune-mediated blistering disorder with predominant skin involvement and occasionally oral manifestations. Vesiculobullous lesions of the oral mucosa present with similar clinical features, and hence ar…
View article: Bowens disease: clinico pathological correlation with review of literature
Bowens disease: clinico pathological correlation with review of literature Open
Bowen’s disease is a type of squamous cell carcinoma in situ. It is most frequently diagnosed in the sixth to eighth decade of life. However, there have also been a few reports of pigmented Bowen’s disease. A single or multiple erythematou…