Leetah Senkpeil
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View article: Increased percentages of circulating T follicular helper cells associate with disease subtype and activity in pediatric immune cytopenias
Increased percentages of circulating T follicular helper cells associate with disease subtype and activity in pediatric immune cytopenias Open
Immune thrombocytopenia (ITP), warm autoimmune hemolytic anemia (wAIHA), and Evans Syndrome (ES) have unpredictable disease activity and are sometimes associated with monogenetic disorders and/or extra-hematologic autoimmunity. ITP and imm…
View article: A GPVI-platelet-neutrophil-NET axis drives systemic sclerosis
A GPVI-platelet-neutrophil-NET axis drives systemic sclerosis Open
Systemic sclerosis (SSc) is characterized by progressive fibrosis of skin, lung, and other organs and retains among the highest rates of mortality among autoimmune diseases. We identified activation of circulating neutrophils from patients…
View article: Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine
Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine Open
A systems analysis was conducted to determine the potential molecular mechanisms underlying differential immunogenicity and protective efficacy results of a clinical trial of the radiation-attenuated whole-sporozoite PfSPZ vaccine in Afric…
View article: T cell and autoantibody profiling for primary immune regulatory disorders
T cell and autoantibody profiling for primary immune regulatory disorders Open
Background Limited clinical tools exist for characterizing primary immune regulatory disorders (PIRD), which are often diagnoses of exclusion. Increased CD4 + CXCR5 + PD1 + circulating T follicular helper (cTfh) cell percentages have been …
View article: Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine
Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine Open
Baseline innate immune signatures can influence protective immunity following vaccination. Here, we used systems transcriptional analysis to assess the molecular mechanisms underlying differential immunogenicity and protective efficacy res…
View article: Innate Immune Activation Restricts Priming and Protective Efficacy of the Radiation-Attenuated Pfspz Malaria Vaccine
Innate Immune Activation Restricts Priming and Protective Efficacy of the Radiation-Attenuated Pfspz Malaria Vaccine Open