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View article: Alkyne Dihydroboration via <i>In Situ</i> -Formed Nickel Cluster Catalysis: Reordering Group Addition by Multinuclear Nature
Alkyne Dihydroboration via <i>In Situ</i> -Formed Nickel Cluster Catalysis: Reordering Group Addition by Multinuclear Nature Open
Understanding the roles and dynamic evolution of active species represents a crucial yet challenging frontier in catalysis research, particularly in systems involving in situ-formed nanoclusters. Owing to the multimetallic nature of solubl…
View article: Electrochemical Amino‐Oxygenation Cyclization via Alkene Radical Cation/Bisnucleophile Engagement to Saturated <i>N</i>/<i>O</i>‐Heterocycles
Electrochemical Amino‐Oxygenation Cyclization via Alkene Radical Cation/Bisnucleophile Engagement to Saturated <i>N</i>/<i>O</i>‐Heterocycles Open
Regioselective functionalization of alkenes to create nitrogen‐ and oxygen‐containing heterocycles remains a significant challenge in organic synthesis. Because of their unique electronic and biological properties, these heterocycles are c…
View article: Electrochemical Amino‐Oxygenation Cyclization via Alkene Radical Cation/Bisnucleophile Engagement to Saturated <i>N</i>/<i>O</i>‐Heterocycles
Electrochemical Amino‐Oxygenation Cyclization via Alkene Radical Cation/Bisnucleophile Engagement to Saturated <i>N</i>/<i>O</i>‐Heterocycles Open
Regioselective functionalization of alkenes to create nitrogen‐ and oxygen‐containing heterocycles remains a significant challenge in organic synthesis. Because of their unique electronic and biological properties, these heterocycles are c…
View article: Adduct-catalyzed tandem electro-thermal synthesis of organophosphorus (III) compounds from white phosphorus
Adduct-catalyzed tandem electro-thermal synthesis of organophosphorus (III) compounds from white phosphorus Open
Electrooxidation strategies for synthesizing readily oxidizable products face notable challenges, especially when the oxidation potential of the products is lower than that of the reactants or when high current densities are necessary. The…
View article: Electrochemical selective deuterium labelling of N-heteroarenes
Electrochemical selective deuterium labelling of N-heteroarenes Open
Hydrogen-deuterium exchange (HIE) reaction is the most direct way to achieve the deuterium labeling as there is no need for extra pre-functionalization. Herein, we report an electrochemical selective deuterium labelling of N-heteroarenes u…
View article: Scalable and Selective Electrochemical Hydrogenation of Polycyclic Arenes
Scalable and Selective Electrochemical Hydrogenation of Polycyclic Arenes Open
The reduction of aromatic compounds constitutes a fundamental and ongoing area of investigation. The selective reduction of polycyclic aromatic compounds to give either fully or partially reduced products remains a challenge, especially in…
View article: Para-selective nitrobenzene amination lead by C(sp2)-H/N-H oxidative cross-coupling through aminyl radical
Para-selective nitrobenzene amination lead by C(sp2)-H/N-H oxidative cross-coupling through aminyl radical Open
Arylamines, serving as crucial building blocks in natural products and finding applications in multifunctional materials, are synthesized on a large scale via an electrophilic nitration/reduction sequence. However, the current methods for …
View article: Cobalt-catalyzed conformationally restricted alkylarylation enables divergent access to Csp <sup>3</sup> -rich N-heterocycles
Cobalt-catalyzed conformationally restricted alkylarylation enables divergent access to Csp <sup>3</sup> -rich N-heterocycles Open
Modular cobalt-catalyzed conformationally restricted alkylarylation enables the divergent synthesis of Csp 3 -rich N-hetero( spiro )cycles (>70 examples, >20 : 1 dr).
View article: Augmentation of Pd-catalysed oxidative C–H/C–H carbonylation through alternating current electrosynthesis
Augmentation of Pd-catalysed oxidative C–H/C–H carbonylation through alternating current electrosynthesis Open
Unsymmetrical-waveform AC electrolysis facilitates Pd-catalysed oxidative C–H/C–H carbonylation. This methodology highlights the substantial benefits conferred by Pd-catalysed conversions in comparison to traditional DC electrolysis.
View article: Celebrating the 130th anniversary of Wuhan University
Celebrating the 130th anniversary of Wuhan University Open
Lin Zhuang, Qiu Wang, Aiwen Lei and Qianghui Zhou introduce the Chemical Science and Green Chemistry joint themed collection celebrating the 130th Anniversary of Wuhan University.
View article: Surface premelting of ice far below the triple point
Surface premelting of ice far below the triple point Open
Premelting of ice, a quasi-liquid layer (QLL) at the surface below the melting temperature, was first postulated by Michael Faraday 160 y ago. Since then, it has been extensively studied theoretically and experimentally through many techni…
View article: Comprehensive Comparisons between Directing and Alternating Current Electrolysis in Organic Synthesis
Comprehensive Comparisons between Directing and Alternating Current Electrolysis in Organic Synthesis Open
Organic electrosynthesis has consistently aroused significant interest within both academic and industrial spheres. Despite the considerable progress achieved in this field, the majority of electrochemical transformations have been conduct…
View article: Comprehensive Comparisons between Directing and Alternating Current Electrolysis in Organic Synthesis
Comprehensive Comparisons between Directing and Alternating Current Electrolysis in Organic Synthesis Open
Organic electrosynthesis has consistently aroused significant interest within both academic and industrial spheres. Despite the considerable progress achieved in this field, the majority of electrochemical transformations have been conduct…
View article: Electrochemical flow aziridination of unactivated alkenes
Electrochemical flow aziridination of unactivated alkenes Open
Aziridines derived from bioactive molecules may have unique pharmacological activities, making them useful in pharmacology (e.g. mitomycin C). Furthermore, the substitution of the epoxide moiety in epothilone B with aziridine, an analog of…
View article: Electrocatalytic Reductive Deuteration of (Hetero)Arenes
Electrocatalytic Reductive Deuteration of (Hetero)Arenes Open
The incorporation of deuterium to organic molecules have widespread applications in medicinal chemistry and material science1,2. For example, deuterated drugs e.g. Austedo3, Donafenib4 and Sotyktu5 have been approved, recently. Because of …
View article: Electrochemical Thiocyanation/Cyclization Cascade to Access Thiocyanato-Containing Benzoxazines
Electrochemical Thiocyanation/Cyclization Cascade to Access Thiocyanato-Containing Benzoxazines Open
Due to the importance of SCN-containing heteroarenes, developing novel and green synthetic protocols for the synthesis of SCN-containing compounds has drawn much attention over the last decades. We reported here an electrochemical oxidativ…
View article: Electrochemical oxidative difunctionalization of diazo compounds with two different nucleophiles
Electrochemical oxidative difunctionalization of diazo compounds with two different nucleophiles Open
With the fast development of synthetic chemistry, the introduction of functional group into organic molecules has attracted increasing attention. In these reactions, the difunctionalization of unsaturated bonds, traditionally with one nucl…
View article: Electroreduction Enables Regioselective 1,2‐Diarylation of Alkenes with Two Electrophiles
Electroreduction Enables Regioselective 1,2‐Diarylation of Alkenes with Two Electrophiles Open
Precisely introducing two similar functional groups into bulk chemical alkenes represents a formidable route to complex molecules. Especially, the selective activation of two electrophiles is in crucial demand, yet challenging for cross‐el…
View article: Fragile intermediate identification and reactivity elucidation in electrochemical oxidative α-C(sp<sup>3</sup>)–H functionalization of tertiary amines
Fragile intermediate identification and reactivity elucidation in electrochemical oxidative α-C(sp<sup>3</sup>)–H functionalization of tertiary amines Open
An online electrochemical mass spectrometry (MS) methodology has been developed and utilized to probe the short-lived intermediates in electrochemical oxidative α-C(sp 3 )–H functionalization of tertiary amines.
View article: Photo/Ni dual-catalyzed radical defluorinative sulfonylation to synthesize<i>gem</i>-difluoro allylsulfones
Photo/Ni dual-catalyzed radical defluorinative sulfonylation to synthesize<i>gem</i>-difluoro allylsulfones Open
Radical defluorinative functionalization of α-trifluoromethyl styrenes represents an effective way toward gem -difluoroalkenes.
View article: Electrochemical radical-mediated selective C(sp<sup>3</sup>)–S bond activation
Electrochemical radical-mediated selective C(sp<sup>3</sup>)–S bond activation Open
An electrochemical radical-mediated approach to selectively cleave the C(sp 3 )-S bonds of various thioethers is described.
View article: CCDC 2063803: Experimental Crystal Structure Determination
CCDC 2063803: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Fabrication of Biomass Derived Pt-Ni Bimetallic Catalyst and Its Selective Hydrogenation for 4-Nitrostyrene
Fabrication of Biomass Derived Pt-Ni Bimetallic Catalyst and Its Selective Hydrogenation for 4-Nitrostyrene Open
The hydrogenation products of aromatic molecules with reducible groups (such as C=C, NO2, C=O, etc.) are relatively critical intermediate compounds in fine chemicals, but how to accurately reduce only specific groups is still challenging. …