Lei Tang
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View article: Senescent immune cells in the tumor microenvironment: emerging insights into cancer immunotherapy resistance
Senescent immune cells in the tumor microenvironment: emerging insights into cancer immunotherapy resistance Open
Cancer remains a leading cause of mortality worldwide, with rising incidence and death rates continuing to rise. While conventional treatments such as surgery, radiotherapy, and chemotherapy form the backbone of cancer care, they are often…
View article: Self-assembled patient-derived tumor-like cell clusters for personalized drug testing in diverse sarcomas
Self-assembled patient-derived tumor-like cell clusters for personalized drug testing in diverse sarcomas Open
Several patient-derived tumor models have emerged recently. However, soft tissue sarcomas (STSs) present a challenge in developing preclinical drug-testing models due to their non-epithelial and complex nature. Here, we report a model term…
View article: #2347 Multi-omics analysis identifies traditional Chinese medicine targets for chronic kidney disease
#2347 Multi-omics analysis identifies traditional Chinese medicine targets for chronic kidney disease Open
Background and Aims As a major public health problem, chronic kidney disease (CKD) has substantial comorbidities and disease burden. It is necessary to discover new therapeutic targets considering its irreversibly. Traditional Chinese medi…
View article: Childhood abuse and association with adult depressive symptoms among people with cardiovascular disease
Childhood abuse and association with adult depressive symptoms among people with cardiovascular disease Open
Background To study the association between the total/different types of childhood abuse and adult depressive symptoms in people with cardiovascular disease (CVD). Methods The subjects were people with CVD who continuously participated in …
View article: Association Between Alcohol Expectancy and Drinking Behaviors in Summer Vacation and Last Year Among College Students
Association Between Alcohol Expectancy and Drinking Behaviors in Summer Vacation and Last Year Among College Students Open
The drinking rate in the study group was at a high level in the past. The association between alcohol expectancy and drinking behavior among college students would be different according to the period and amount of drinking.
View article: Additional file 2 of Relationship between modifiable lifestyle factors and chronic kidney disease: a bibliometric analysis of top-cited publications from 2011 to 2020
Additional file 2 of Relationship between modifiable lifestyle factors and chronic kidney disease: a bibliometric analysis of top-cited publications from 2011 to 2020 Open
Additional file 2: Supplementary Table 2. Keywords merging details. Supplementary Table 3. Bibliometric information of the top 100-cited articles on the impact of modifiable lifestyles on CKD.
View article: Chinese Interest in Thyroid Related Diseases: Evidence from Baidu Index
Chinese Interest in Thyroid Related Diseases: Evidence from Baidu Index Open
Background: Common thyroid diseases are hyperthyroidism, hypothyroidism, thyroiditis, thyroid tumor and so on. Baidu is currently the most widely used online search tool in China, has developed an internet search trends collection and anal…
View article: Correlation Analysis of Hemoglobin-to-Red Blood Cell Distribution Width Ratio and Frailty in Elderly Patients With Coronary Heart Disease
Correlation Analysis of Hemoglobin-to-Red Blood Cell Distribution Width Ratio and Frailty in Elderly Patients With Coronary Heart Disease Open
Background: Coronary heart disease (CHD) is a common chronic disease in the elderly. Frailty can accelerate the development of CHD and lead to adverse health outcomes. Risk prediction and decision-making for frailty are crucial. The periph…
View article: Relationships Between Internet Use and Sleep Duration in Chinese Adults: A Cross-Sectional Study
Relationships Between Internet Use and Sleep Duration in Chinese Adults: A Cross-Sectional Study Open
Internet use was found to be closely associated with sleep and the duration of sleep negatively affected, which may provide new ideas for sleep hygiene recommendations and healthy media use. This conclusion needs more evidence to support.
View article: Prevalence and Patterns of Comorbidity Among Middle-Aged and Elderly People in China: A Cross-Sectional Study Based on CHARLS Data
Prevalence and Patterns of Comorbidity Among Middle-Aged and Elderly People in China: A Cross-Sectional Study Based on CHARLS Data Open
Comorbidity is common in the population, and the pattern of chronic disease comorbidity is complex. Hypertension exists in a variety of comorbidity patterns, and its screening and prevention should be strengthened.
View article: Immunohistochemical Detection of Synuclein Pathology in Skin in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinsonism
Immunohistochemical Detection of Synuclein Pathology in Skin in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinsonism Open
Background Recent studies reported abnormal alpha‐synuclein deposition in biopsy‐accessible sites of the peripheral nervous system in Parkinson's disease (PD). This has considerable implications for clinical diagnosis. Moreover, if deposit…
View article: Effect of A Feedback Intervention on Antibiotic Prescription Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Effect of A Feedback Intervention on Antibiotic Prescription Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Background The global health system is improperly using antibiotics. We aimed to examine the effectiveness of implementing a feedback intervention for the unreasonable control of antibiotic prescriptions. Methods Relevant literature publis…
View article: <p>The Relationship Between Aspartate Aminotransferase To Alanine Aminotransferase Ratio And Metabolic Syndrome In Adolescents In Northeast China</p>
The Relationship Between Aspartate Aminotransferase To Alanine Aminotransferase Ratio And Metabolic Syndrome In Adolescents In Northeast China Open
In adolescents, AST/ALT was significantly associated with MetS and its components and predicted overweight/obesity in adulthood.
View article: Human IL-23R Cytokine-Binding Homology Region-Fc Fusion Protein Ameliorates Psoriasis via the Decrease of Systemic Th17 and ILC3 Cell Responses
Human IL-23R Cytokine-Binding Homology Region-Fc Fusion Protein Ameliorates Psoriasis via the Decrease of Systemic Th17 and ILC3 Cell Responses Open
Interleukin (IL)-23 is considered an effective therapeutic target for the treatment of psoriasis because of the crucial role of the IL-23/IL-17 axis in the pathogenesis of psoriasis, and it has recently been reported to be involved in ILC3…
View article: A novel homozygous mutation in the solute carrier family 12 member 3 gene in a Chinese family with Gitelman syndrome
A novel homozygous mutation in the solute carrier family 12 member 3 gene in a Chinese family with Gitelman syndrome Open
Loss of function of mutated solute carrier family 12 member 3 (SLC12A3) gene is the most frequent etiology for Gitelman syndrome (GS), which is mainly manifested by hypokalemia, hypomagnesemia and hypocalciuria. We report the genetic chara…