Lichen Zhang
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View article: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression Open
Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however, the cellular and mol…
View article: Author response: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Author response: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression Open
View article: Author response: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Author response: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression Open
View article: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression Open
Background Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however the cellul…
View article: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression Open
Background Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however the cellul…
View article: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression Open
Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however, the cellular and mol…
View article: Dock8 regulates Th2 cell differentiation through ANXA1
Dock8 regulates Th2 cell differentiation through ANXA1 Open
View article: Author Correction: Tyrosinase in melanoma inhibits anti-tumor activity of PD-1 deficient T cells
Author Correction: Tyrosinase in melanoma inhibits anti-tumor activity of PD-1 deficient T cells Open
View article: Xcr1 <sup>+</sup> type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Xcr1 <sup>+</sup> type 1 conventional dendritic cells are essential mediators for atherosclerosis progression Open
Background Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however the cellul…
View article: A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo
A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo Open
Naive T cell activation requires both TCR and CD28 signals. The CARMIL2 cytosolic protein enables CD28-dependent activation of the NF-κB transcription factor via its ability to link CD28 to the CARD11 adaptor protein. Here, we developed mi…
View article: Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation
Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation Open
We demonstrate that exposure to the AB5 subtilase cytotoxin (SubAB) induces the unfolded protein response (UPR) in human peripheral blood mononuclear cells, concomitant with a proinflammatory response across distinct cell subsets. Notably,…
View article: Tyrosinase in melanoma inhibits anti-tumor activity of PD-1 deficient T cells
Tyrosinase in melanoma inhibits anti-tumor activity of PD-1 deficient T cells Open
View article: Differential expression of S100A10 protein in leukocytes and its effects on monocyte emigration from bone marrow
Differential expression of S100A10 protein in leukocytes and its effects on monocyte emigration from bone marrow Open
Although the importance of the unique member of S100 EF-hand family, S100A10 in health and disease is well appreciated, a precise characterization of S100A10 expression still remains elusive. To this purpose, we generated a knock-in mouse …
View article: RIPK3-dependent sequential recruitment of MLKL and RIPK1 drives PANoptotic cell death and chemokine production
RIPK3-dependent sequential recruitment of MLKL and RIPK1 drives PANoptotic cell death and chemokine production Open
PANoptosis, an immunogenic programmed cell death (PCD) modality, integrates features of pyroptosis, apoptosis, and necroptosis through assembly of the PANoptosome complex. Despite its conceptualization as a distinct PCD form, PANoptosis re…
View article: Target Speaker Lipreading by Audio-Visual Self-Distillation Pretraining and Speaker Adaptation
Target Speaker Lipreading by Audio-Visual Self-Distillation Pretraining and Speaker Adaptation Open
Lipreading is an important technique for facilitating human-computer interaction in noisy environments. Our previously developed self-supervised learning method, AV2vec, which leverages multimodal self-distillation, has demonstrated promis…
View article: The Heterogeneity and Functional Roles of Dendritic Cells in Atherosclerosis: Origins, Subsets, and Therapeutic Implications
The Heterogeneity and Functional Roles of Dendritic Cells in Atherosclerosis: Origins, Subsets, and Therapeutic Implications Open
View article: Reversal of Remimazolam-Mediated Inhibition of Jurkat T Cell Activation by TGFBI Depletion
Reversal of Remimazolam-Mediated Inhibition of Jurkat T Cell Activation by TGFBI Depletion Open
View article: Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation
Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation Open
SUMMARY We demonstrate that exposure to the AB5 subtilase cytotoxin (SubAB) induces the unfolded protein response (UPR) in human peripheral blood mononuclear cells, concomitant with a pro-inflammatory response across distinct cell subsets.…
View article: Dedicator of cytokinesis 8 (DOCK8) mutation impairs the differentiation of helper T cells by regulating the glycolytic pathway of CD4<sup>+</sup> T cells
Dedicator of cytokinesis 8 (DOCK8) mutation impairs the differentiation of helper T cells by regulating the glycolytic pathway of CD4<sup>+</sup> T cells Open
Dedicator of cytokinesis 8 (DOCK8) deficiency is a primary immunodeficiency disease caused by mutations in exon 45 of the DOCK8 gene. The clinical signs primarily consist of increased serum IgE levels, eczema, repeated skin infections, all…
View article: Impact of treatment interval between neoadjuvant immunochemotherapy and surgery in lung squamous cell carcinoma
Impact of treatment interval between neoadjuvant immunochemotherapy and surgery in lung squamous cell carcinoma Open
Objective The optimal timing for surgery following neoadjuvant immunochemotherapy for lung squamous cell carcinoma appears to be a topic of limited data. Many clinical studies lack stringent guidelines regarding this timing. The objective …
View article: Comparisons of short-term outcomes between robot-assisted, video-assisted, and open esophagectomy for resectable esophageal cancer after neoadjuvant treatment: a retrospective study
Comparisons of short-term outcomes between robot-assisted, video-assisted, and open esophagectomy for resectable esophageal cancer after neoadjuvant treatment: a retrospective study Open
Compared to VAMIE, no clear benefit exists for RAE in the treatment of resectable EC after neoadjuvant therapy. OE resulted in a longer hospital stay. Although the rate of successful right RLN node removal was higher with RAE, the clinical…
View article: Noval advance of histone modification in inflammatory skin diseases and related treatment methods
Noval advance of histone modification in inflammatory skin diseases and related treatment methods Open
Inflammatory skin diseases are a group of diseases caused by the disruption of skin tissue due to immune system disorders. Histone modification plays a pivotal role in the pathogenesis and treatment of chronic inflammatory skin diseases, e…
View article: The Hippo-YAP signaling pathway drives CD24-mediated immune evasion in esophageal squamous cell carcinoma via macrophage phagocytosis
The Hippo-YAP signaling pathway drives CD24-mediated immune evasion in esophageal squamous cell carcinoma via macrophage phagocytosis Open
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in the world with poor prognosis. Despite the promising applications of immunotherapy, the objective response rate is still unsatisfactory. We have previously…
View article: USP10 promotes pancreatic ductal adenocarcinoma progression by attenuating FOXC1 protein degradation to activate the WNT signaling pathway
USP10 promotes pancreatic ductal adenocarcinoma progression by attenuating FOXC1 protein degradation to activate the WNT signaling pathway Open
Increasing evidence has suggested that ubiquitin-specific protease 10 (USP10), a deubiquitinating enzyme, plays an essential role in targeted protein degradation and participates in cancer progression. However, the relationship between USP…
View article: YTHDC2 inhibits rat bone mesenchymal stem cells osteogenic differentiation by accelerating RUNX2 mRNA degradation via m6A methylation
YTHDC2 inhibits rat bone mesenchymal stem cells osteogenic differentiation by accelerating RUNX2 mRNA degradation via m6A methylation Open
View article: The Hippo-YAP signaling pathway drives CD24-mediated immune evasion in esophageal squamous cell carcinoma via macrophage phagocytosis
The Hippo-YAP signaling pathway drives CD24-mediated immune evasion in esophageal squamous cell carcinoma via macrophage phagocytosis Open
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in the world with poor prognosis. Despite the promising applications of immunotherapy, the objective response rate is still unsatisfactory. We have previously…
View article: Balancing economic and ecological benefits for hydro-junction operation based on the ecological flow from the four major Chinese carps: a case study from Xinjiang River, China
Balancing economic and ecological benefits for hydro-junction operation based on the ecological flow from the four major Chinese carps: a case study from Xinjiang River, China Open
The construction and utilization of the hydro-junctions would change the water flow and affect the hydrologic process required for the survival and reproduction of the aquatic organism in the river basin. To investigate the influence of th…
View article: Bronchiolar adenoma with squamous metaplasia: a distinct phenotype
Bronchiolar adenoma with squamous metaplasia: a distinct phenotype Open
Aims Pulmonary bronchiolar adenoma is a benign lung tumour characterised by nodular proliferation of bilayered bronchiolar‐type epithelium with a continuous layer of basal cells. The aim of this study was to describe a distinct and rare hi…
View article: Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation
Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation Open
The LAT transmembrane adaptor is essential to transduce intracellular signals triggered by the TCR. Phosphorylation of its four C-terminal tyrosine residues (136, 175, 195, and 235 in mouse LAT) recruits several proteins resulting in the a…
View article: The Safety and Efficacy of Preoperative Immunotherapy Combined with Chemotherapy in Patients with Stage IIIA-IIIB Lung Squamous Cell Carcinoma
The Safety and Efficacy of Preoperative Immunotherapy Combined with Chemotherapy in Patients with Stage IIIA-IIIB Lung Squamous Cell Carcinoma Open
Objective Data on preoperative immunotherapy combined with chemotherapy in potentially resectable lung squamous cell carcinoma (LUSC) remain scarce. This study was designed to investigate the safety and efficacy of preoperative immunothera…