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View article: Swedish study participants undergoing research bronchoscopy – a tolerable or unpleasant experience?
Swedish study participants undergoing research bronchoscopy – a tolerable or unpleasant experience? Open
Introduction Flexible bronchoscopy is regarded as a safe examination and is commonly used in the diagnostic work-up for lung diseases, but is also important in pulmonary research. We aimed to investigate participants’ experiences when unde…
View article: Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach
Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach Open
T2-targeting biologics have utility in the management of asthma with low T2 involvement, but more effective therapies are needed. Further research is warranted to identify specific pathogenic pathways at the lower end of the T2 spectrum th…
View article: Airway hyperresponsiveness to mannitol in relation to inspiratory and expiratory resistance in subjects with asthma, COPD, and healthy smokers
Airway hyperresponsiveness to mannitol in relation to inspiratory and expiratory resistance in subjects with asthma, COPD, and healthy smokers Open
Inspiratory resistance, as measured by respiratory oscillometry, was shown to predict hyperresponsiveness to mannitol in asthma patients. Furthermore, respiratory oscillometry revealed a significant increase in resistance, primarily in the…
View article: Transcriptional Roadmap of the Human Airway Epithelium Identifying HLF as a Novel Regulator of Basal Stem Cell Function
Transcriptional Roadmap of the Human Airway Epithelium Identifying HLF as a Novel Regulator of Basal Stem Cell Function Open
Rationale The human airway epithelium depends on a coordinated hierarchy of stem-and differentiated cells to maintain tissue integrity and respond to injury. Defining the transcriptional and translational programs that govern these process…
View article: Human proteome distribution atlas for tissue-specific plasma proteome dynamics
Human proteome distribution atlas for tissue-specific plasma proteome dynamics Open
View article: Peripheral Airway Obstruction in Association with Symptoms and Quality of Life in Asthma
Peripheral Airway Obstruction in Association with Symptoms and Quality of Life in Asthma Open
The increasing symptoms in patients with asthma assessed using questionnaires correlated well with predominantly increasing peripheral airway obstruction. A correlation also exists with the Nijmegen score, which is not specific to asthma. …
View article: Prednisolone versus antihistamine for allergic rhinitis: No significant difference found in randomized trial
Prednisolone versus antihistamine for allergic rhinitis: No significant difference found in randomized trial Open
Background Seasonal allergic rhinitis (AR) impacts public health by affecting work productivity and quality of life. The Swedish tree pollen season starts in February with alder and hazel pollination, followed by birch and ends with oak in…
View article: Adam17 and Related Epithelial Injury Markers in Bronchoalveolar Lavage and Blood Distinguish Copd from Controls
Adam17 and Related Epithelial Injury Markers in Bronchoalveolar Lavage and Blood Distinguish Copd from Controls Open
View article: Promoting Prevention and Targeting Remission of Asthma
Promoting Prevention and Targeting Remission of Asthma Open
Asthma is a common, multifaceted respiratory disease with a major impact on quality of life. Despite increased insights into mechanisms underlying various asthma phenotypes and endotypes and the availability of targeted biologic treatment …
View article: Corrigendum to “Disease burden and unmet need for acute allergic reactions – A patient perspective” [World Allergy Organ J 17(4) (2024 Apr) 100896]
Corrigendum to “Disease burden and unmet need for acute allergic reactions – A patient perspective” [World Allergy Organ J 17(4) (2024 Apr) 100896] Open
View article: Altered hypoxia-induced cellular responses and inflammatory profile in lung fibroblasts from COPD patients compared to control subjects
Altered hypoxia-induced cellular responses and inflammatory profile in lung fibroblasts from COPD patients compared to control subjects Open
Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by chronic bronchitis, emphysema and vascular remodelling. The disease is associated with hypoxia, inflammation and oxidative stress. Lung fib…
View article: EUFOREUM Berlin 2023: Optimizing care for type 2 inflammatory diseases from clinic to AI: A pediatric focus
EUFOREUM Berlin 2023: Optimizing care for type 2 inflammatory diseases from clinic to AI: A pediatric focus Open
The European Forum for Research and Education in Allergy and Airways diseases (EUFOREA) organized its bi‐annual forum EUFOREUM in Berlin in November 2023. The aim of EUFOREUM 2023 was to highlight pediatric action plans for prevention and …
View article: Expression of Stress-Induced Genes in Bronchoalveolar Lavage Cells and Lung Fibroblasts from Healthy and COPD Subjects
Expression of Stress-Induced Genes in Bronchoalveolar Lavage Cells and Lung Fibroblasts from Healthy and COPD Subjects Open
Chronic obstructive pulmonary disease (COPD) is commonly caused from smoking cigarettes that induce biological stress responses. Previously we found disorganized endoplasmic reticulum (ER) in fibroblasts from COPD with different responses …
View article: Treatment Preferences for Acute Allergic Reactions: A Discrete Choice Experiment
Treatment Preferences for Acute Allergic Reactions: A Discrete Choice Experiment Open
Background: Timely treatment of acute allergic reactions (AARs) is important to minimize reaction severity. Corticosteroid tablets dissolved in water are commonly used in mainstay treatment. A new oral film that dissolves on the tongue pro…
View article: Treatment Preferences for Acute Allergic Reactions: A Discrete Choice Experiment
Treatment Preferences for Acute Allergic Reactions: A Discrete Choice Experiment Open
Background Timely treatment of acute allergic reactions (AARs) is important to minimize reaction severity. Corticosteroid tablets dissolved in water are commonly used in mainstay treatment. A new oral film that dissolves on the tongue prov…
View article: Exploring Definitions and Predictors of Response to Biologics for Severe Asthma
Exploring Definitions and Predictors of Response to Biologics for Severe Asthma Open
View article: Inferring the composition of the blood plasma proteome by a human proteome distribution atlas
Inferring the composition of the blood plasma proteome by a human proteome distribution atlas Open
The plasma proteome is maintained by the influx and efflux of proteins from surrounding organs and cells. To quantify the extent different organs and cells contribute to the plasma proteome composition, we developed a mass spectrometry-bas…
View article: Exploring Definitions and Predictors of Severe Asthma Clinical Remission after Biologic Treatment in Adults
Exploring Definitions and Predictors of Severe Asthma Clinical Remission after Biologic Treatment in Adults Open
Rationale: There is no consensus on criteria to include in an asthma remission definition in real life. Factors associated with achieving remission after biologic initiation remain poorly understood. Objectives: To quantify t…
View article: Multi-Disciplinary Expert Perspective on the Management of Type 2 Inflammation-Driven Severe CRSwNP: A Brief Overview of Pathophysiology and Recent Clinical Insights
Multi-Disciplinary Expert Perspective on the Management of Type 2 Inflammation-Driven Severe CRSwNP: A Brief Overview of Pathophysiology and Recent Clinical Insights Open
Severe chronic rhinosinusitis with nasal polyposis (CRSwNP) is a disabling airway disease that significantly impacts patients' lives through the severity of symptoms, the need for long-term medical treatment and the high risk of recurrence…
View article: Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma
Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma Open
Background To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials. Aim To e…
View article: Disease burden and unmet need for acute allergic reactions – A patient perspective
Disease burden and unmet need for acute allergic reactions – A patient perspective Open
In this sample, subjects with experience of AARs treated with CS showed a considerable disease burden with anxiety and interruption on daily life, as well as problems related to access to, and swallowing of, medication. Although respondent…
View article: Reply to “Exploring the long-term effects of biologic initiation in severe asthma: Insights from the International Severe Asthma Registry”
Reply to “Exploring the long-term effects of biologic initiation in severe asthma: Insights from the International Severe Asthma Registry” Open
View article: Clinical relevance of type 2 inflammation as a driver of multi-organ disease: A Delphi consensus initiative
Clinical relevance of type 2 inflammation as a driver of multi-organ disease: A Delphi consensus initiative Open
Background: This initiative aimed to elucidate the clinical relevance of type 2 (T2) inflammation as a driver of asthma, atopic dermatitis, chronic rhinitis, chronic rhinosinusitis with nasal polyps (CRSwNP) and eosinophilic esophagitis. M…
View article: Plasma proteome changes linked to late phase response after inhaled allergen challenge in asthmatics
Plasma proteome changes linked to late phase response after inhaled allergen challenge in asthmatics Open
Background. A subset of individuals with allergic asthma develops a late phase response (LPR) to inhaled allergens, which is characterized by a prolonged airway obstruction, airway inflammation and airway hyperresponsiveness. The aim of th…
View article: Bronchodilator Responsiveness Measured by Spirometry and Impulse Oscillometry in Patients with Asthma After Short Acting Antimuscarinic and/or Beta-2-Agonists Inhalation
Bronchodilator Responsiveness Measured by Spirometry and Impulse Oscillometry in Patients with Asthma After Short Acting Antimuscarinic and/or Beta-2-Agonists Inhalation Open
Overall, combining SAMA with SABA was faster and more consistent at increasing the lung function than SABA alone or SAMA alone, and the additive effect was best captured by incorporating peripheral-related variables. Therefore, SAMA should…
View article: Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma
Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma Open
View article: Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology
Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology Open
The accumulation of senescent cells drives inflammaging and increases morbidity of chronic inflammatory lung diseases. Immune responses are built upon dynamic changes in cell metabolism that supply energy and substrates for cell proliferat…
View article: EUFOREA/EPOS2020 statement on the clinical considerations for chronic rhinosinusitis with nasal polyps care
EUFOREA/EPOS2020 statement on the clinical considerations for chronic rhinosinusitis with nasal polyps care Open
Following the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) treatment algorithm for chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP), patients suffering from severe uncontrolled CRSwNP are recomm…
View article: Lung Fibroblasts from Chronic Obstructive Pulmonary Disease Subjects Have a Deficient Gene Expression Response to Cigarette Smoke Extract Compared to Healthy
Lung Fibroblasts from Chronic Obstructive Pulmonary Disease Subjects Have a Deficient Gene Expression Response to Cigarette Smoke Extract Compared to Healthy Open
Overall, COPD lung fibroblasts responded to CSE stimulation with a very different and deficient expression profile compared to healthy. Highlighting that stimulated healthy cells are not an appropriate substitute for COPD cells which is im…
View article: Limited beneficial effects of systemic steroids when added to standard of care treatment of seasonal allergic rhinitis
Limited beneficial effects of systemic steroids when added to standard of care treatment of seasonal allergic rhinitis Open
Intramuscular injections with methylprednisolone treating allergic rhinitis (AR) have a long history. Modern guidelines are designed to dissuade this treatment, but it´s frequently used, especially in primary care. This despite of concern …