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Determination of Half-lives of Circulating FSH and LH Glycoforms in Women During GnRH Receptor Blockade Open
Context Both FSH and LH circulate as 2 glycoforms, differing in number of glycans: low-N-glycosylated glycoforms, FSHtri and LHdi, and fully N-glycosylated glycoforms, FSHtetra and LHtri. Objectives To determine the half-lives of endogenou…
Low- and Fully N-Glycosylated Gonadotropins Circulating in Women With Polycystic Ovary Syndrome Open
Context A preponderance of basic luteinizing hormone (LH) molecules having elevated bioactivity was detected in the circulation of women with polycystic ovary syndrome (PCOS). Subsequent studies have shown that LH and follicle-stimulating …
Thyrotropin N-glycosylation and Glycan Composition in Severe Primary Hypothyroidism Open
Context In severe primary hypothyroidism (sPH), the serum thyrotropin (TSH) levels are elevated with an increased degree of sialylation. The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and…
Gonadotropin Glycoforms Circulating in Women Using Progestins of the Levonorgestrel Family for Contraception Open
Context The progestins of the levonorgestrel family are 13-ethylgonane progestins, commonly used for contraception in women. One contraceptive effect of these progestins is inhibition of ovulation, which may be a result of changes in gonad…
Unique Pattern of N-Glycosylation, Sialylation, and Sulfonation on TSH Molecules in Serum of Children Up to 18 Months Open
Context N-glycosylation and glycan composition of human TSH molecules modulate the biological properties of TSH in different physiological and clinical situations. The degree of sialylation of serum TSH was reported to be very low in norma…
Low-glycosylated forms of both FSH and LH play major roles in the natural ovarian stimulation Open
The results indicate that the LHdi and the FSHtri molecules play major roles in the natural ovarian stimulation. The SU/SA ratios per molecule favoured a prolonged circulatory half-life of all glycoforms at the midcycle phase. The observat…
Molecular size and charge as dimensions to identify and characterize circulating glycoforms of human FSH, LH and TSH Open
The methods can be used for identification and characterization of glycoforms of circulating FSH, LH, and TSH in physiological and clinical studies.