Leigha D. Larsen
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View article: Unsupervised Clustering Reveals Intestine‐Adapted Eosinophil Subsets Shaped by Local Inflammation
Unsupervised Clustering Reveals Intestine‐Adapted Eosinophil Subsets Shaped by Local Inflammation Open
View article: Overexpression of TNFα in TNF∆ARE+/− mice increases hepatic periportal inflammation and alters bile acid signaling in mice
Overexpression of TNFα in TNF∆ARE+/− mice increases hepatic periportal inflammation and alters bile acid signaling in mice Open
Background: Intestinal inflammation is a common factor in ~70% of patients diagnosed with primary sclerosing cholangitis. The TNF ∆ARE+/− mouse overexpresses TNFα and spontaneously develops ileitis after weaning. The aim of this study was …
View article: Notch 2 signaling contributes to intestinal eosinophil adaptations in steady state and tissue burden following oral allergen challenge
Notch 2 signaling contributes to intestinal eosinophil adaptations in steady state and tissue burden following oral allergen challenge Open
Eosinophils not only function as inflammatory effectors in allergic diseases, but also contribute to tissue homeostasis in steady state. Emerging data are revealing tissue eosinophils to be adaptive cells, imprinted by their local tissue m…
View article: Fibrostenotic eosinophilic esophagitis phenotype is defined by a proliferative gene signature
Fibrostenotic eosinophilic esophagitis phenotype is defined by a proliferative gene signature Open
Appendix S1 Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for t…
View article: Heterogeneity of Intestinal Tissue Eosinophils: Potential Considerations for Next-Generation Eosinophil-Targeting Strategies
Heterogeneity of Intestinal Tissue Eosinophils: Potential Considerations for Next-Generation Eosinophil-Targeting Strategies Open
Eosinophils are implicated in the pathophysiology of a spectrum of eosinophil-associated diseases, including gastrointestinal eosinophilic diseases (EGIDs). Biologics that target the IL-5 pathway and are intended to ablate eosinophils have…